4Y72,2JGZ,2B9R


Conserved Protein Domain Family
CYCLIN_CCNB1_rpt1
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cd20565: CYCLIN_CCNB1_rpt1 
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first cyclin box found in G2/mitotic-specific cyclin-B1 (CCNB1)
CCNB1 is essential for the control of the cell cycle at the G2/M (mitosis) transition. It is required for embryo development. Over-expression of human CCNB1 has been found in numerous cancers and has been associated with tumor aggressiveness. CCNB1 contains two cyclin boxes. This model corresponds to the first one. The cyclin box is a protein binding domain.
Links
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Statistics
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PSSM-Id: 410268
Aligned: 9 rows
Threshold Bit Score: 260.966
Created: 12-Apr-2019
Updated: 25-Oct-2021
Structure
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Program:
Drawing:
Aligned Rows:
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CDK interfaceB-type cyclin
Conserved site includes 24 residues -Click on image for an interactive view with Cn3D
Feature 1:CDK interface [polypeptide binding site]
Evidence:
  • Comment:CDK = cyclin-dependent kinase
  • Structure:4Y72; Homo sapiens CCNB1 in complex with CDK1, contacts at 4A
    - View structure with Cn3D
  • Structure:2JGZ; Homo sapiens CCNB1 in complex with phospho-CDK2, contacts at 4A
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Sequence Alignment
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Format: Row Display: Color Bits: Type Selection: 
Feature 1          ##  ##  ##  #                                                                 
4Y72_B         7 SSEYVKDIYAYLRQLEEEQAVRPKYLlGREVTGNMRAILIDWLVQVQMKFRLLQETMYMTVSIIDRFMQNNsVPKKMLQL 86  human
2JGZ_B         1 CSEYVKDIYAYLRQLEEEQAVRPKYLlGREVTGNMRAILIDWLVQVQMKFRLLQETMYMTVSIIDRFMQNNcVPKKMLQL 80  human
2B9R_A         3 SSEYVKDIYAYLRQLEAAQAVRPKYLlGREVTGNMRAILIDWLVQVQMKFRLLQETMYMTVSIIDRFMQNNsVPKKMLQL 82  human
Q9IBG1       140 CSEYVKDIYKYLRQLEMEQSVKPNYLeGQEITGNMRAILIDWLVQVGLKFRLLQETMYMTVGIIDRFLQDHpVPKKQLQL 219 Japanese medaka
P13350       133 CSEYVKDIYAYLRSLEDAQAVRQNYLhGQEVTGNMRAILIDWLVQVQMKFRLLQETMFMTVGIIDRFLQEHpVPKNQLQL 212 African clawed ...
P14635       167 CSEYVKDIYAYLRQLEEEQAVRPKYLlGREVTGNMRAILIDWLVQVQMKFRLLQETMYMTVSIIDRFMQNNcVPKKMLQL 246 human
TFK15710     143 CSEYVKDIYGYLRDLEKQQDVRPKYLaGQEVTGNMRAILIDWLVQVQMKFRLLPETMYMTAAIIDRFLQDNsVPKKMLQL 222 big-headed turtle
XP_006010328 139 CSEYVKDIYKYLRQLEVEQAVRPKHLeGQEVTGNMRAILIDWLVQVQIKFRLLQETMYMTVAILDRFLQNHpVPKKMLQL 218 coelacanth
NP_001279224 129 CSEYVKDIYKYLRQLEAEQPVRPKYLeGKEITGNMRAILIDWLVQVQMKFRLLQETMYLTVAIIDRYLQDNvVTKKILQL 208 elephant shark

Feature 1              ##  #####  ###                #  ##  ##  ##
4Y72_B        87 VGVTAMFIASKYEEMYPPEIGDFAFVTDNTYTKHQIRQMEMKILRALNF 135 human
2JGZ_B        81 VGVTAMFIASKYEEMYPPEIGDFAFVTDNTYTKHQIRQMEMKILRALNF 129 human
2B9R_A        83 VGVTAMFIASKYEEMYPPEIGDFAFVTDNTYTKHQIRQMEMKILRALNF 131 human
Q9IBG1       220 VGVTAMFLASKYEEMYPPEISDFAYVTDRAYTTAQIRDMEMTILRVLKF 268 Japanese medaka
P13350       213 VGVTAMFLAAKYEEMYPPEIGDFTFVTDHTYTKAQIRDMEMKILRVLKF 261 African clawed frog
P14635       247 VGVTAMFIASKYEEMYPPEIGDFAFVTDNTYTKHQIRQMEMKILRALNF 295 human
TFK15710     223 VGVTAMFIASKYEEMYPPEIGDFAFVTDHTYTKSQIKQMERKILQALDF 271 big-headed turtle
XP_006010328 219 VGVTAMFVASKYEEIYPPDIGDFVFVTNNTYTKRQVREMEMKVLWELDF 267 coelacanth
NP_001279224 209 VGVTAMLVASKYEEMYPPEIEDFAFVTDSTYTSTQIREMERRILRELDF 257 elephant shark

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