Conserved Protein Domain Family

cd20559: CYCLIN_ScCLN_like 
cyclin box found in Saccharomyces cerevisiae G1/S-specific cyclins (ScCLNs) and similar proteins
ScCLNs, including ScCLN1-3, are essential for the control of the cell cycle at the G1/S (start) transition in Saccharomyces. ScCLN1 and ScCLN2 interact with the CDC28 protein kinase to form maturation promoting factor (MPF). ScCLN3 may be an upstream activator of the G1 cyclins that directly initiate G1/S transition. This family also includes Schizosaccharomyces pombe cyclin puc1, which contributes to negative regulation of the timing of sexual development in fission yeast, and functions at the transition between cycling and non-cycling cells. It interacts with protein kinase A. Members of this family contain one cyclin box. The cyclin box is a protein binding domain.
PSSM-Id: 410262
Aligned: 10 rows
Threshold Bit Score: 105.545
Created: 15-Jul-2019
Updated: 25-Oct-2021
Aligned Rows:
putative CDK
Feature 1:putative CDK interface [polypeptide binding site]
  • Comment:based on the structure of Saccharomyces cerevisiae cyclin Pho80 in complex with cyclin-dependent protein kinase Pho85 (2PK9), defined at 4A contacts

Sequence Alignment
Format: Row Display: Color Bits: Type Selection:
Feature 1                         #                                    #                         
P20437        74 AIVTFLYQLSVMTrvsNGIFFHAVRFYDRYCSKRVVlkd-qaKLVVGTCLWLAAKTwggcnhiinnvsiptggrfygpnp 152 Saccharomyces c...
XP_022458850  74 AVVDFIHKLVIDLgldHRVFFTAINLIDRYCHTIPVmlk-hlEVLALSCIWIASKFhs---------------------- 130 Kuraishia capsu...
RDW25634      74 YLLDFIVETHVTLrlqPQTLFLAINLIDRYCSKRVVykk-hyQLVGCTCLWIAAKYedkk-------------------- 132 Yarrowia lipoly...
Q06374        67 EVIRSLIKIHKELnllPQTLLLSVNLLDRFCCKKDFlgqvyyRVFSCAALWIASKFvedkdr----------------vp 130 Colletotrichum ...
P20438        76 NIITFLFELSVVTrvtNGIFFHSVRLYDRYCSKRIVlrd-qaKLVVATCLWLAAKTwggcnhiinnvviptggrfygpnp 154 Saccharomyces c...
Q59YH3        76 FLLDFLIELHSSFklqPTTLFLCLNIIDRYCAKRIVfkr-hyQLVGCTALWIASKYedkk-------------------- 134 Candida albican...
P43062        76 LLLDFLMEVITILnlsRSTFPLTVNLIDRYCSTRIVkkq-hyQLLGLTSLWISCKNldsk-------------------- 134 Candida albicans
P13365       110 LIFDFIMYCHTRLnlsTSTLFLTFTILDKYSSRFIIksy-nyQLLSLTALWISSKFwdsk-------------------- 168 Saccharomyces c...
P25009       131 ALVNFIVEIHNGFdlsIDTLPLSISLMDSYVSRRVVyck-hiQLVACVCLWIASKFhete-------------------- 189 Schizosaccharom...
OWB54437     103 SLLNSVFDAVVKLrwsFATFSLMTYITDKYTSLVEInek-dyKMIGYCCLWIASKYvenk-------------------- 161 [Candida] boidinii
Feature 1             ###                  #  ##         
P20437       153 rariPRLSELVHYCGGSdlf-desMFIQMERHILDTLNWD 191 Saccharomyces cerevisiae S288C
XP_022458850 131 --rkSRIPEVSKLCGLTngfhnkeKIIKMESTVLNALNWD 168 Kuraishia capsulata CBS 1993
RDW25634     133 -srvPTISDLKHMCCGAye---edMFCQMEGHVLNTLEWT 168 Yarrowia lipolytica
Q06374       131 svcrVLDYVPSGMYCNSa------LFFRLEICMLNVLAWR 164 Colletotrichum gloeosporioides
P20438       155 rariPRLSELVHYCGDGqvf-desMFLQMERHILDTLNWN 193 Saccharomyces cerevisiae S288C
Q59YH3       135 -srvPTLKELTIMCRNAyd---eeMFVQMEMHILSTLDWS 170 Candida albicans SC5314
P43062       135 -fkvPTLNDLRKICVDSyy---keLFVEMEKHILKSLEWV 170 Candida albicans
P13365       169 -nrmATLKVLQNLCCNQys---ikQFTTMEMHLFKSLDWS 204 Saccharomyces cerevisiae S288C
P25009       190 -drvPLLQELKLACKNIya---edLFIRMERHILDTLDWD 225 Schizosaccharomyces pombe 972h-
OWB54437     162 -pktKLVEILTKRCDVPk-----kDFLKVEMDILSALKWD 195 [Candida] boidinii

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