1VOL,1C9B,1TFB,2PHG,3K7A,5IY6,5WH1


Conserved Protein Domain Family
CYCLIN_TFIIB_rpt1
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cd20551: CYCLIN_TFIIB_rpt1 
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first cyclin box found in transcription initiation factor IIB (TFIIB) and similar proteins
TFIIB, also called B-related factor 2 (BRF-2) or S300-II, is a general transcription factor that plays a role in transcription initiation by RNA polymerase II (Pol II). It is involved in the pre-initiation complex (PIC) formation and Pol II recruitment at promoter DNA. TFIIB contains two cyclin boxes. This model corresponds to the first one. The cyclin box fold is generally a protein binding domain, but binds DNA in TFIIB.
Links
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Statistics
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PSSM-Id: 410254
Aligned: 49 rows
Threshold Bit Score: 105.746
Created: 12-Apr-2019
Updated: 25-Oct-2021
Structure
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Program:
Drawing:
Aligned Rows:
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DNA binding
Conserved site includes 6 residues -Click on image for an interactive view with Cn3D
Feature 1:DNA binding site [nucleic acid binding site]
Evidence:
  • Structure:1VOL; Homo sapiens TFIIB binds TBP-DNA complex, contacts at 4A.
  • Citation:PMID 7675079
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Sequence Alignment
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Format: Row Display: Color Bits: Type Selection: 
Feature 1                                                         ##                        #    
1VOL_A         4 NAFKEITTMADRINLpRNKVDRTNNLFRQAYEQKs-------------lKGRANDAIASACLYIACRQEgvPRTFKEICA 70  human
3K7A_M       128 AAFAKITMLCDAAELpKIVKDCAKEAYKLCHDEKt-------------lKGKSMESIMAASILIGCRRAevARTFKEIQS 194 Saccharomyces c...
P29055       128 AAFAKITMLCDAAELpKIVKDCAKEAYKLCHDEKt-------------lKGKSMESIMAASILIGCRRAevARTFKEIQS 194 Saccharomyces c...
XP_004364187 127 KAFRLIGDFGERMHLpSNITLKAKQIFKQMEEHYtrerngaasqfgaivGGKGAKAVAAASLFLACRLEkvSRTYKEITA 206 Capsaspora owcz...
XP_005825615 240 DAYKKIDEICDTMNLsSVIRGQAKHNFKSYDEESkk-----------qkKKIPIDPVLTSCIYIACREEgfPRTMKEMCA 308 Guillardia thet...
KDQ08841     136 SAFREISNMCDSISLpKTISDIAKQLYKRADEEKv-------------lRGKSIDAIVACCIFIACRQAkvPRTFKEICQ 202 Botryobasidium ...
CEO95556     123 EGFSEIGEFGHRMDLsDSVQYRAKEIFKQMHETKk-------------lRGRPRNLIVTACLFIACQGQnvDRSRKEFCR 189 Plasmodiophora ...
KNE64257     149 EGFRTITAMGERMGLnRKIIEAAKQYFKMAETGQ---------------PIKKIEATVAVALLLGCRKCgaDRSLQEFAS 213 Allomyces macro...
OMJ91851     103 RGFRSIEELCNVLNIgDIIKEEAQHLFKKVDDQKt-------------lKGRGHNAIVSSCVFIACRKKsnPRSIREISM 169 Stentor coeruleus
OSX68673      44 DVFGRVARLAERSHMsGGVRDRAKEMFKRYYDVLtlkegg---grtralKEDETASIVAACLFLAARNEgaPRTFKEVCA 120 laver

Feature 1              #   #  #       
1VOL_A        71 VSrisKKEIGRCFKLILKALE 91  human
3K7A_M       195 LIhvkTKEFGKTLNIMKNILR 215 Saccharomyces cerevisiae S288C
P29055       195 LIhvkTKEFGKTLNIMKNILR 215 Saccharomyces cerevisiae S288c
XP_004364187 207 VShvrEQEISRASSEIKRILG 227 Capsaspora owczarzaki ATCC 30864
XP_005825615 309 ATtltKKEIGNAFKHELIKKT 329 Guillardia theta CCMP2712
KDQ08841     203 LTrvpKKTIGQCYKALEQAFN 223 Botryobasidium botryosum FD-172 SS1
CEO95556     190 ITdvdLRDLGRVIQKIQKHMK 210 Plasmodiophora brassicae
KNE64257     214 MInisKTEFGKVLSQVKNTLR 234 Allomyces macrogynus ATCC 38327
OMJ91851     170 ALnveKREILKCYSSIKKILP 190 Stentor coeruleus
OSX68673     121 VSqvpKKEIGGRMKAIERALE 141 laver

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