1D3U,1AIS


Conserved Protein Domain Family
CYCLIN_TFIIB_archaea_like_rpt1

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cd20549: CYCLIN_TFIIB_archaea_like_rpt1 
Click on image for an interactive view with Cn3D
first cyclin box found in archaeal transcription initiation factor IIB (TFIIB) and similar proteins
Archaeal TFIIB stabilizes TATA-binding protein (TBP) binding to an archaeal box-A promoter. It is also responsible for recruiting RNA polymerase II to the pre-initiation complex (DNA-TBP-TFIIB). TFIIB contains two cyclin boxes. This model corresponds to the first one. The cyclin box fold is generally a protein binding domain, but binds DNA in TFIIB.
Statistics
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PSSM-Id: 410252
Aligned: 19 rows
Threshold Bit Score: 128.549
Created: 12-Apr-2019
Updated: 25-Oct-2021
Structure
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Program:
Drawing:
Aligned Rows:
 
DNA binding
Conserved site includes 7 residues -Click on image for an interactive view with Cn3D
Feature 1:DNA binding site [nucleic acid binding site]
Evidence:

Sequence Alignment
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Format: Row Display: Color Bits: Type Selection:
Feature 1            #                                      ###                               
1D3U_B      2 VSDAAERNLAFALSELDRITAQLklPRHVEEEAARLYREAVRKGLIRGRSIESVMAACVYAACRLLKVPRTLDEIADIAR 81  Pyrococcus woesei
Q9HJM2    111 VSNAAERNLSLALQLLNDIGAKLgiPKDIKETAALIYRKAVEKNLIRGRSIESIVCASIYAACRKVNIPRTLDEISKASE 190 Thermoplasma acido...
P58111    112 IQSSIDRNLAQAMNELERIGNLLnlPKSVKDEAALIYRKAVEKGLVRGRSIESVVAAAIYAACRRMKLARTLDEIAQYTK 191 Saccharolobus solf...
A8MCX6    139 VQTSYERNLVQATHELNRIAHQLgvPKSCMDEALAVYKQVLKSGLVKGRSVEAIIAACLHMACRMQGMPRSLDEISQYTR 218 Caldivirga maquili...
PMB78278  119 LQGSHDRNLIQALNELDRIVSQLglPTSIRNEAAVIYNRAATSGMVRGRSIESVIAAAIYAACRKLRNPVSLDEISSYTQ 198 Candidatus Korarch...
RLC65922   30 ASGSSDRNLMLAMRELNKVAYKLqiPRNVLETAAYAYRLAIKKGIRRGRSIRGMVAACIYIACRQCNVIRHLGEVAEATQ 109 Chloroflexi bacterium
AAR39126  105 ALSAIDRNLKIALHELKKMVDKLnmPKYVEEEAARIYQKVVEKGLARGRNINTLLAGTLYLVIREYNIPRTLEELEKATG 184 Nanoarchaeum equit...
A8AC96    111 IQTGMDRNLTIAMNELDRMANLLnlPKQIKEEAAVIYRKAVEKGLVRGRSIESVVAAVIYAACRIHHQPRTLDEIAKKLE 190 Ignicoccus hospita...
Q9HJM7    116 VSNAAERNLSQALQELERMASNLsiPDDVKETAAVIYRKAVKQNMIRGRSIEGVVAGALYAACRITNVPRTLGEIASVTR 195 Thermoplasma acido...
Q8ZWS3    136 VQTSYERNFIQAAQELERLRSAMgiPRPCIEQALEIYRQALEKELVRGRSVEAMAAAALYMACRMMKMPRPLDELVRYTK 215 Pyrobaculum aeroph...
Feature 1        #   #  #        
1D3U_B     82 vdKKEIGRSYRFIARNLNL 100 Pyrococcus woesei
Q9HJM2    191 vnKKKIGKAYRHLAKELDL 209 Thermoplasma acidophilum DSM 1728
P58111    192 anRKEVARCYRLLLRELDV 210 Saccharolobus solfataricus P2
A8MCX6    219 apRKEIARCFRLIARELRI 237 Caldivirga maquilingensis IC-167
PMB78278  199 asRKDVARCYRLLLRENSV 217 Candidatus Korarchaeota archaeon
RLC65922  110 isKRDAGRTYRFLMANLET 128 Chloroflexi bacterium
AAR39126  185 isKKDIAKAYRLIVRELGI 203 Nanoarchaeum equitans Kin4-M
A8AC96    191 vnRKEVARCYRLITKELKL 209 Ignicoccus hospitalis KIN4/I
Q9HJM7    196 vkKKEIGRTYRIMSRYLKL 214 Thermoplasma acidophilum DSM 1728
Q8ZWS3    216 asRREVARCYRLLLRELNV 234 Pyrobaculum aerophilum str. IM2

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