Conserved Protein Domain Family
CYCLIN_SpCG1C_ScCTK2-like_rpt2

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cd20546: CYCLIN_SpCG1C_ScCTK2-like_rpt2 
second cyclin box found in Schizosaccharomyces pombe cyclin C homolog 1 (pch1), Saccharomyces cerevisiae CTD kinase subunit 2 (ScCTK2), and similar proteins
Cyclin pch1 is essential for progression through the whole cell cycle. It is a homolog of cyclin T; it forms a heterodimer with its partner kinase, cyclin-dependent kinase 9 (CDK9), that can phosphorylate both the pol II C-terminal domain (CTD) and the CTD of transcription elongation factor Spt5. Yeast Cdk9/Pch1, with mRNA capping enzyme Pct1, may also form an elongation checkpoint for mRNA quality control. CTK2, also called CTD kinase subunit beta, CTDK-I subunit beta, or CTD kinase 38 kDa subunit, is the cyclin subunit of the CTDK-I complex, which hyperphosphorylates the C-terminal heptapeptide repeat domain (CTD) of the largest RNA polymerase II subunit. This group also includes yeast RNA polymerase II holoenzyme cyclin-like subunit, a component of the SRB8-11 complex, a regulatory module of the Mediator complex which is involved in regulation of basal and activated RNA polymerase II-dependent transcription. Members of this family contain two cyclin boxes. This model corresponds to the second one. The cyclin box is a protein binding domain.
Statistics
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PSSM-Id: 410249
Aligned: 84 rows
Threshold Bit Score: 53.5241
Created: 15-Apr-2019
Updated: 25-Oct-2021
Structure
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Aligned Rows:
PubMed ReferencesClick to see Conserved Features Help

Sequence Alignment
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Format: Row Display: Color Bits: Type Selection:
O74627       159 HPYPYVLSFIKKFVADd--------KNVTKVAWTYINDSTRSIACLlysPKTIAAAAFQFALEkneinl----------- 219 Schizosaccharom...
XP_009038491 141 NPMLHFIERVKQLKACkald-eadeQQFSQLGINFIGDSYRTSLCLqqaPQKIASAMAFITIIymrklp----------- 208 Aureococcus ano...
SAM04018     145 HPQQLVLEFATELDAP---------ENVTLAAYGFANDSLRLPLCLifdPQMIAAACMLLAFKaedev------------ 203 Absidia glauca
GBG24539     123 HPHVSAVEIIREIAKPgk-----ktNEFRLASWTFLNDSMFTDVCVrfkPRAIAAASVLLAHYlirsr------------ 185 Hondaea ferment...
POY76720     163 NPHWYAVSAAQQVWTAaet---etgTRVAQAAWAFLNDALALPLCLiyrPQLLAGASILLACAqldlalppspgslaeqk 239 Rhodotorula tai...
Q5BBA8       152 HPYRTLSELQPELSLT---------SDEVALAWSVINDHYLTDLSLlypPHIIAVMAIIVAVVfkpssqtafhgsaapia 222 Aspergillus nid...
Q6CAC7       153 HPYKSLMQISDAMARSnaqi--tmaPEEIQVTWSMINDSYITDLHLlnpPHIVAMACIYMTVVlrshimrmtm------- 223 Yarrowia lipoly...
Q6CP20       177 HPYRSLEQIEKALSSEkyny--klsDDELQKIWSLINDSYTTDVHLlysPHVIAISCLFAVSCiihkpe----------- 243 Kluyveromyces l...
Q9HE63       154 SPYRTLTSLQGELGLA---------QEDVNLAWSVINDHYMTDLPLlhpPHVIALTAILLALVlrqdpsgrlpgtaasas 224 Neurospora cras...
A3LPX1       158 HPYKSLIQIRDFLNENsavfgftltDDELQNAWSLVNDSYITDLHLllpPHIIAVASIYITIVlkknlsairvnssavns 237 Scheffersomyces...
O74627       220 ---------------------------------------------------------------stttdGLPVWMEESQVS 236 Schizosaccharom...
XP_009038491 209 --------------------------------------------------------------pksdkaRLNRMFATLSIS 226 Aureococcus ano...
SAM04018     204 ----------------------------------------------------------------iptgTDTIWGRTLEQE 219 Absidia glauca
GBG24539     186 ---------------------------------------------------------------gpgktVQASREISDAIE 202 Hondaea ferment...
POY76720     240 al------------------------------------------------heiaiqeaeegeepppfvPKAGLLGLLEIR 271 Rhodotorula tai...
Q5BBA8       223 gamrd-----------------------------------------ggmnilaalsdkggagpppriqKLIAWLAESEVD 261 Aspergillus nid...
Q6CAC7       224 ----------------------------------------------------------pseavksrieAFMTFFGESNVD 245 Yarrowia lipoly...
Q6CP20       244 --------------------------------------------------------------dstkraNINMFIAETQVN 261 Kluyveromyces l...
Q9HE63       225 glvaasaalaqaqaqaqaraammagggqtvpgltpqsssglqamlppqspagegpaegnknprmakvhRFAAWLSDSNID 304 Neurospora cras...
A3LPX1       238 nggpnsmmfnrnpdqnsmhid----------dlmilanpstpgsdlvnnlertnfhdmkldeetikinKFMNFLDHSHIN 307 Scheffersomyces...
O74627       237 YEDVkgv---------------ltLIDSLYKK 253 Schizosaccharomyces pombe 972h-
XP_009038491 227 ERSLnsi---------------csEMVSLYTE 243 Aureococcus anophagefferens
SAM04018     220 PGLLaei---------------vgDIACLYTD 236 Absidia glauca
GBG24539     203 RDHLrptasslfgfpkeqieeivhRILDVYER 234 Hondaea fermentalgiana
POY76720     272 PEELrep---------------smAMLGGYTM 288 Rhodotorula taiwanensis
Q5BBA8       262 IKAVies---------------tqELVSLYEV 278 Aspergillus nidulans FGSC A4
Q6CAC7       246 LEQTidc---------------vqEMISLYVN 262 Yarrowia lipolytica CLIB122
Q6CP20       262 LEQVmfi---------------lqELISLYDH 278 Kluyveromyces lactis NRRL Y-1140
Q9HE63       305 IEAMvdc---------------tqELISFYEC 321 Neurospora crassa OR74A
A3LPX1       308 LDEVvea---------------mqDMINIYVQ 324 Scheffersomyces stipitis CBS 6054
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