2IVX,3MI9


Conserved Protein Domain Family
CYCLIN_CCNT_rpt1

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cd20538: CYCLIN_CCNT_rpt1 
Click on image for an interactive view with Cn3D
first cyclin box found in cyclin-T (CCNT) family
The CCNT family includes two C-type cyclins, cyclin-T1 (CCNT1) and cyclin-T2 (CCNT2), both of which are regulatory subunits of the cyclin-dependent kinase pair (CDK9/cyclin-T) complex, also called positive transcription elongation factor B (P-TEFb), which is proposed to facilitate the transition from abortive to productive elongation by phosphorylating the CTD (C-terminal domain) of the large subunit of RNA polymerase II (RNA Pol II). Members of this family contain two cyclin boxes. This model corresponds to the first one. The cyclin box is a protein binding domain.
Statistics
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PSSM-Id: 410241
Aligned: 15 rows
Threshold Bit Score: 223.807
Created: 12-Apr-2019
Updated: 25-Oct-2021
Structure
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Program:
Drawing:
Aligned Rows:
 
CDK interface
Conserved site includes 20 residues -Click on image for an interactive view with Cn3D
Feature 1:CDK interface [polypeptide binding site]
Evidence:

Sequence Alignment
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Format: Row Display: Color Bits: Type Selection:
Feature 1         ##                                                           ##               ##
2IVX_A          4 RWFFTREQLENTPSRRcGVEADKELSCRQQAANLIQEMGQRLNVsQLTINTAIVYMHRFYMHHSFtKFNKNIISSTALFL 83   human
3MI9_B         11 RWYFTREQLENSPSRRfGVDPDKELSYRQQAANLLQDMGQRLNVsQLTINTAIVYMHRFYMIQSFtQFPGNSVAPAALFL 90   human
XP_013398667    5 RWLFSQSQLINTPSRAcGIDYDRELSYRQQAANFIQDMGQRLQVtQLCINTAIVYMHRFYMFQSFsKFHRNSMSAACIFL 84   Lingula anatina
PIK49952       15 RWHFTREQLQNTPSRKcGVEPEKELSYRQQSANLIQDMGQRLQVnQLCINTAIVYMHRFYMFQPFtRFPRNSISAACLFL 94   Japanese sea ...
RWS11727        6 RWYFKKEDLENTPSRRcGMDADKELSYRQQATNLIQDMGQRLQVtQLCINTAIVYMHRFYMFHSFtKFNRNAIAACALFL 85   Dinothrombium...
ELU01607        5 RWIFSREQIAQSPSRKcGMDAEKELNYRQQTANMVQDMGQRLQVtQLCINTAIVYMHRFYMYHSFtKFTRTSMALACLFL 84   Capitella teleta
O96433         44 IWYFSNDQLANSPSRRcGIKGDDELQYRQMTAYLIQEMGQRLQVsQLCINTAIVYMHRFYAFHSFtHFHRNSMASASLFL 123  fruit fly
EFX72436        4 KWVFTKEQLQNTPSRRcNIDYDKEIFYRQQAATLIQEMGQRLQVtQLCINTAIVYVHRFYMFHSFnKFHRNPISSCALFL 83   common water ...
KFD57486       21 RWLFTSEQLSDSPSIReGMSVAKELHCRQQAASHIQEVGQKLSLsQLCTNTAIVYMHRFYVFHSFcRFPKFDLAAAALFL 100  pig whipworm
XP_019855485   12 RWYYSREQLSNSPSRAdGVDPEKELRYRQDAASLIQDMGPKLNLnVLCMSTAIVYMHRFYMINSFkAFDRVLLATAALFL 91   Amphimedon qu...
Feature 1           #  #  ####                              #   #  #   ### ## 
2IVX_A         84 AAKVEEQaRKLEHVIKVAHACLHPlepll---dtkcDAYLQQTRELVILETIMLQTLGFE 140  human
3MI9_B         91 AAKVEEQpKKLEHVIKVAHTCLHPqeslp---dtrsEAYLQQVQDLVILESIILQTLGFE 147  human
XP_013398667   85 AAKVEEQpRKLEHVIKVAHMCLHRepld-----vksEAYLEQAQELVINENILLQSLGFD 139  Lingula anatina
PIK49952       95 AAKVEEQpHKLEHVLKVAHLCLHRgappl---dpksDSYMQQSQELVINESIILQTFAFD 151  Japanese sea cucumber
RWS11727       86 AAKVEEQpRKLEYVIKVAHVCLHRgaprl---deksDAYNEQAQELVVNENIMLQTLGFD 142  Dinothrombium tinctorium
ELU01607       85 AAKVEEQpRKLEHVIKVAHVCFHRyenhtp-ldtksDQYLEQAQELVVNENILLQTLGFE 143  Capitella teleta
O96433        124 AAKVEEQpRKLEHVIRAANKCLPPtt---------eQNYAELAQELVFNENVLLQTLGFD 174  fruit fly
EFX72436       84 AAKVEEQpRKLEHVIRVAHMILYKdqrnl---dinsEQYIEQAQELINNENILLQTLGFD 140  common water flea
KFD57486      101 AAKVEECpRKLEYLVKVSHALQHRgessl---dsrsDKYMQEVQKIITYENVLLQTLSFD 157  pig whipworm
XP_019855485   92 AAKVEEHpRKLEHVAKCSYSLVNRdkpdrldldvqsEVYTKLIDDITYHELVLLQTLGFD 151  Amphimedon queenslandica

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