Conserved Protein Domain Family
CYCLIN_CCNO_rpt1
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cd20536: CYCLIN_CCNO_rpt1 
first cyclin box found in cyclin-O (CCNO) and similar proteins
CCNO is specifically required for generation of multiciliated cells, possibly by promoting a cell cycle state compatible with centriole amplification and maturation. It acts downstream of MCIDAS (multiciliate differentiation and DNA synthesis associated cell cycle protein) to promote mother centriole amplification and maturation in preparation for apical docking. CCNO is involved in the activation of cyclin-dependent kinase 2. CCNO contains two cyclin boxes. This model corresponds to the first one. The cyclin box is a protein binding domain.
Links
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Statistics
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PSSM-Id: 410239
Aligned: 12 rows
Threshold Bit Score: 150.555
Created: 12-Apr-2019
Updated: 25-Oct-2021
Structure
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Aligned Rows:
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PubMed ReferencesClick to see Conserved Features Help
Sequence Alignment
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Format: Row Display: Color Bits: Type Selection: 
P22674        132 SRCKLLSWLIPVHRQf-gLSFESLCLTVNTLDRFLTTTPVAa-DCFQLLGVTSLLIACKQVEvhPPRVKQLLALCCGaFS 209  human
Q32NM1        146 SRCKLISWLIPVHRHl-nLGFESLCLTVNILDRFLACTPVAs-DCFQLVGVTSLLIASKQVEtrPPRVKQLLALCCDaFS 223  African clawe...
Q32NJ2        147 SRCKLISWLIPVHKHl-kLGFESLCLTVNILDRFLACTPVAs-DCFQLVGVTSLLIACKQVEsrPPRVKQLLALCCDaFS 224  African clawe...
RMB95416     1104 ARCKLVSWLIPVHRHf-gLSLEALCLAVNILDRFLATTPVAa-DCFQLLGVTALLIACKQVEvhPPSVKELLALCCDaFT 1181 Hirundo rusti...
XP_005998513  145 TRCKLISWLIPVHRHf-gLSFESLCLAVNIMDRFLTTTPVAs-DCFQLVGVTSLLLACKQVEmfPPRISQLLALCCDaFT 222  coelacanth
RXM92874      169 ARCKLISWLIPVHRHf-nLCFESFCLAVNIMDRFLMTTPVAs-DCFQLLGVTSLLIACKQVEvyPPRIKQLLALCCDaFT 246  sterlet
EKC26378      153 MRGLLISWLTGVHHQl-nLWQDTLFVAVNVVDRVLDLMQASr-DYLQLLGITSLLIACKSEEihPPEIKDLLSGCDDiYS 230  Pacific oyster
ELU02981      103 PEAILVEWLTKLCRRf-sFAQDTVFLTINILDRFLVTTPISr-DIFQLLGITSLLVSAKREEqyPPEIADLLLLCDDtYT 180  Capitella teleta
XP_023932425   75 MRAILIQWLTKVVHQhfrFHQDTLYLTVNILDRFLASTPVKi-ECFQLLGVTALLVAGKHEEiyPPEVEELIRLCCGaYD 153  Lingula anatina
O14332        174 MRASVINWIVGVHTCi-nLLPESLFLSINVLDRFLSLQNVPa-SKMKLCGATALFIACKYEEihPPTVKDLEIVLEGeWI 251  Schizosacchar...
EGD80851      174 MRTVVIDWMIEIQVSf-kLRDETLFCAVDILDRYLAARPDEqrHDYQCCGATSLWIASKFLEvlPPELADFEYVCAGlYP 252  Salpingoeca r...
KRX01875      119 MRAILYDWLIKVHIKf-kLVDECLFMAINLIDRYLEKTKISr-DKFQLLGITCLFISSKVEEiyPPHIKDFASVTNGaCT 196  Pseudocohnile...

P22674        210 RQQLCNLECIVLHKL 224  human
Q32NM1        224 REQLCNLECIILLKL 238  African clawed frog
Q32NJ2        225 REQLCNLECIILLKL 239  African clawed frog
RMB95416     1182 RQQLRNLECIVLHRL 1196 Hirundo rustica rustica
XP_005998513  223 REQLCNLECIVLIKL 237  coelacanth
RXM92874      247 KDQLCNLECIILIKL 261  sterlet
EKC26378      231 RDQVKQLERVILNAL 245  Pacific oyster
ELU02981      181 RDQVQQLERVILSRL 195  Capitella teleta
XP_023932425  154 RAQIIRLERLVLERL 168  Lingula anatina
O14332        252 GEDICGMEKYMLMVL 266  Schizosaccharomyces pombe 972h-
EGD80851      253 RQAFIDKELTMLTAL 267  Salpingoeca rosetta
KRX01875      197 KYDIIRMEGQLCKVL 211  Pseudocohnilembus persalinus
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