4CXA,2I53,4NST,6B3E


Conserved Protein Domain Family
CYCLIN_CCNK_rpt1
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cd20530: CYCLIN_CCNK_rpt1 
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first cyclin box found in cyclin-K (CCNK) and similar proteins
CCNK is a novel RNA polymerase II-associated C-type cyclin possessing both carboxy-terminal domain kinase and Cdk-activating kinase activity. It is a regulatory subunit of cyclin-dependent kinases that mediates the activation of these target kinases. It plays a role in transcriptional regulation by controlling the phosphorylation of the C-terminal domain (CTD) of the large subunit of RNA polymerase II (POLR2A). CCNK contains two cyclin boxes. This model corresponds to the first one. The cyclin box is a protein binding domain.
Links
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Statistics
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PSSM-Id: 410233
Aligned: 29 rows
Threshold Bit Score: 172.032
Created: 12-Apr-2019
Updated: 25-Oct-2021
Structure
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Program:
Drawing:
Aligned Rows:
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CDK interface
Conserved site includes 17 residues -Click on image for an interactive view with Cn3D
Feature 1:CDK interface [polypeptide binding site]
Evidence:
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Sequence Alignment
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Format: Row Display: Color Bits: Type Selection: 
Feature 1                                                            #            #  ## #        
4CXA_B        32 GLDPATEARYRREGARFIFDVGTRLgl--hYDTLATGIIYFHRFYMFHSFKQFp-RYVTGACCLFLAGKVEETPKKCKDI 108 human
AAX27780      26 QIDHETETRHRREGARFLSAVSTKLnl--rYDTCATAIVFFHRFYMFHSFKAFp-RYVTAACCLMLAGKVEETPKKVRDI 102 Schistosoma jap...
RDD44318      20 GIEITAECRYRREGARFIMDVGNRMnl--rYETVATGIVFYHRFYMMHSFKTIn-RLIGAAACLYLAGKAEETPKKCRDL 96  Trichoplax sp. H2
CBY37375      20 GLSAENEARYRKEGAKFIHKLGLELkl--hHDTLATAAVFYHRFYIQHSFVKFrqRYVTATCCLFLAGKVEETPKKCKDL 97  Oikopleura dioica
XP_003385094  32 GISHEMERRYRREGARFISNTSNTLkl--rRDTLATGTVFFHRFYMVQNFADFd-KYVVAAACVLLAGKVEETPKKCKDI 108 Amphimedon quee...
NP_506615     20 GLTKEQELLWRREGIKLLSEVGNALnc-kpRPTIGVAAVYFHRFYMIHSFQSFs-REVTALSCLFLAGKVEDFPKKCKDV 97  Caenorhabditis ...
KII68288      18 GIDFRTECKYKEEGIRFIMTIGHKIgl--sYVSLATAAVFFHRFYVIRSQKMFs-RWVTAVSCLFLAGKVEETPKKCRDL 94  Thelohanellus k...
XP_011270139  52 GISAETEMRYRLEGVALIKEIGQHQqrpmsQQAIATGIVFFHRFFMCQSFKDFe-ASKMACTCLLLAGKVEESHRKCYDI 130 Capsaspora owcz...
Q8GYM6        50 SIDLKKETYLRKSYCTFLQDLGMRLkv--pQVTIATAIIFCHRFFIRQSHARNd-RRTIATVCMFLAGKVEETPRPLKDV 126 thale cress
PNW72974      77 GLEPDKERMWRRQYCKLIQDAGVNLrv--pQWGIAVGITLCHRFFAVKSMKRNd-RFLIATACLFLAAKVEEAPRLLKTV 153 Chlamydomonas r...

Feature 1                                                    #  ###### ##  ###
4CXA_B       109 IKTARSLLNDvqfg-----------------------qfgdDPKEEVMVLERILLQTIKFD 146 human
AAX27780     103 VKTARSLLSDadfe-----------------------qfgsDPREEVMAFERVLLKTIKFD 140 Schistosoma japonicum
RDD44318      97 VKAVRTILSErqme-----------------------afgdDPKEEIISHERLLLQTIKFD 134 Trichoplax sp. H2
CBY37375      98 VRVAKQLLTEqhfasfgg----------------sgpnaeiTAREEVMAMERVVLQAIKFD 142 Oikopleura dioica
XP_003385094 109 VRVAKRFLSAeqsk-----------------------sfgeKPLEELISFERVLLQTIRFD 146 Amphimedon queenslandica
NP_506615     98 CQAAVTHYPEiys-------------------------kyqNLVDDVMGLERVLLHSLKFD 133 Caenorhabditis elegans
KII68288      95 VKIAHNILNQmdlye----------------------vvstITPNEVMCYERIILQTLKFD 133 Thelohanellus kitauei
XP_011270139 131 LDRAHVFRQTqqlaeqikqsggvvsaeqgvkrlgrdsreyyQAKEEMLVNERILLQAIAFE 191 Capsaspora owczarzaki ATCC 30864
Q8GYM6       127 IVVSYEIIHKkdpttaqk---------------ikqkevyeQQKELILNGEKIVLSTLGFD 172 thale cress
PNW72974     154 IGEVERVRHSkdlakqre---------------ledpakmeRYREEVLQAERAVLYTLGFD 199 Chlamydomonas reinhardtii

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