5L2W


Conserved Protein Domain Family
CYCLIN_CCNE_rpt2

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cd20520: CYCLIN_CCNE_rpt2 
Click on image for an interactive view with Cn3D
second cyclin box found in G1/S-specific cyclin-E (CCNE) family
The CCNE family includes two E-type cyclins, CCNE1 and CCNE2. CCNE1 is essential for the control of the cell cycle at the G1/S (start) transition. It interacts with CDK2 protein kinase to form a serine/threonine kinase holoenzyme complex. CCNE2 is essential for the control of the cell cycle at the late G1 and early S phase. It interacts with the CDK2 (in vivo) and CDK3 (in vitro) protein kinases to form serine/threonine kinase holoenzyme complexes. Members in this family contain two cyclin boxes. This model corresponds to the second one. The cyclin box is a protein binding domain.
Statistics
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PSSM-Id: 410224
Aligned: 38 rows
Threshold Bit Score: 81.1744
Created: 12-Apr-2019
Updated: 25-Oct-2021
Structure
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Program:
Drawing:
Aligned Rows:
 
CDK interface
Conserved site includes 8 residues -Click on image for an interactive view with Cn3D
Feature 1:CDK interface [polypeptide binding site]
Evidence:
  • Structure:5L2W; Homo sapiens CCNE1 in complex with CDK2, contacts at 4A

Sequence Alignment
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Format: Row Display: Color Bits: Type Selection:
Feature 1         #      ##  #                                                      ### #        
5L2W_B       172 PLTIVSWLNVYMQVAYLNdlh--------------------------------------------evLLPQYPQQIFIQI 207 human
RUS31572     638 PPTIFQWVTTYLQNYLVFthesnvdgnatsk-----------------------sdaksisktlsdcLRRRFDVTALSEM 694 Jimgerdemannia ...
KII67069     283 PVTPISWLQLFLQLFHSQndhtelpssyrgpvt-------------------rkryvqsfeksylarKFLICDETINKPY 343 Thelohanellus k...
VDK79505     187 SITALEWAKIYAHMMRVYttykricnlslahqstptkkrtkiahgvsddeevdfftwaqlddlvvgePSLPVDLCNRIAI 266 Litomosoides si...
XP_004995492 539 RSTPLHWTRFFIGVALGDpstl------------------------------------------vgsAPSCVDPAWLFRS 576 Salpingoeca ros...
RKP35611     417 PPTIQHWLPTFFHRASQRapavfhaplpastahrpkpp---------tfnpaihrqsyqptlcpllaHIPQLPSNWYFYA 487 Dimargaris cris...
OAJ44589     482 PQKETHWLPTSLMNNEVNkdcf------------------------------------------kcfSMRRFDPYWYASA 519 Batrachochytriu...
OMH84608     313 VPVIPDFISAFVHRARSFfps--------------------------------------------lfSDTVSSADIFSLA 348 Zancudomyces cu...
ORY40415     257 VVTPYEWYMAYCQLYQVWrgh-------------------------------------------rslDQSHLLEFTWQRG 293 Rhizoclosmatium...
CBN75030     456 VPTSLSFLGVFLRRAEGLgy----------------------------------------------vLADGPGRERVRRE 489 Ectocarpus sili...
Feature 1                                                                                  
5L2W_B       208 AELLDLCVLDvd-cLEFPYGILAASALYHFSSs----------ELMQKVSGYQwCDIENCVKWMVPFAMVIRET 270 human
RUS31572     695 MDLMDAAIYDyr-yLRFSPSVLAAGCLWLSCDld--------dAALQSCTGYQwGEISDCVEWLSDYKRILQNS 759 Jimgerdemannia flammi...
KII67069     344 IDLLESCIRDag-sLQFPYSVIAASIISLVSR-----------SHVFNITGYGsSDISNCKKWLRQFYQDNTTP 405 Thelohanellus kitauei
VDK79505     267 AQVLDLCMVDly-nFNFTYRQLGAAACISVFGld--------yEIALRITGLKmKDLRPAVDFVNSHRRIYMKY 331 Litomosoides sigmodontis
XP_004995492 577 CQVLQLAMSDaw-aLRFDARQMAAAAVLLSATr---------pIDILAVTGLDkCALRTCLRWMHCFARVISEQ 640 Salpingoeca rosetta
RKP35611     488 SHIADVALHHth-sLRFSYSTLAAASFYLVLDrfapd--ylkdSFFEEVTGQTmASVQDCVTFLRTRAGPLVID 558 Dimargaris cristalligena
OAJ44589     520 ASIMDQTLFYpk-yLEYKHSVIAAAAFWLSWPdkd-----trqEVAEAVTGLKvHQIMPCVEFIRKCDIQVENF 587 Batrachochytrium dend...
OMH84608     349 CDYADLAVHCyd-sLTFSASKLAASCFYLSISsfftp--ilspQDFDRITGYTfSSLCDCLHFLERLSKNLTNP 419 Zancudomyces culisetae
ORY40415     294 LKVLDAAVMDpr-sQKQTPSALAAAMFVLCENpk--------sNSLLHCTGYClEQLEHAMKFIRYFEMQWFGE 358 Rhizoclosmatium globosum
CBN75030     490 AEQILLCMLRescsLEHPPSALAASALYWASCvttpgaapptsFAFLAVTGYElEQLCCCLRDMEAVRTGGGRR 563 Ectocarpus siliculosus

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