1W98,5L2W


Conserved Protein Domain Family
CYCLIN_CCNE_rpt1
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cd20519: CYCLIN_CCNE_rpt1 
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first cyclin box found in G1/S-specific cyclin-E (CCNE) family
The CCNE family includes two E-type cyclins, CCNE1 and CCNE2. CCNE1 is essential for the control of the cell cycle at the G1/S (start) transition. It interacts with CDK2 protein kinase to form a serine/threonine kinase holoenzyme complex. CCNE2 is essential for the control of the cell cycle at the late G1 and early S phase. It interacts with the CDK2 (in vivo) and CDK3 (in vitro) protein kinases to form a serine/threonine kinase holoenzyme complexes. Members of this family contain two cyclin boxes. This model corresponds to the first one. The cyclin box is a protein binding domain.
Links
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Statistics
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PSSM-Id: 410223
Aligned: 16 rows
Threshold Bit Score: 233.744
Created: 12-Apr-2019
Updated: 25-Oct-2021
Structure
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Program:
Drawing:
Aligned Rows:
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CDK interface
Conserved site includes 25 residues -Click on image for an interactive view with Cn3D
Feature 1:CDK interface [polypeptide binding site]
Evidence:
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Sequence Alignment
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Format: Row Display: Color Bits: Type Selection: 
Feature 1        ## #  ##  ##  #   #                                    #                        
1W98_B        14 SWANREEVWKIMLNKEKTYlrdqh--fleqHPLLQPKMRAILLDWLMEVCEVYkLHRETFYLAQDFFDRYMATqen-vvK 90  human
P54733       324 AWANAADVWRLMCHRDEQDsrlrsismleqHPGLQPRMRAILLDWLIEVCEVYkLHRETFYLAVDYLDRYLHVahk-vqK 402 fruit fly
O01501       226 GIGSPTKVWSLMVKRDEIPratrf--llgnHPDMDDEKRRILIDWMMEVCESEkLHRETFHLAVDYVDRYLESsnvecsT 303 Caenorhabditis ...
CCI61378      82 QWADSTEVWQLMLEKETQYirdss--flnrHANLQSRMRSILLDWLIEVCEVYrLHRETFYLAVDFVDRYLSQtkn-iqK 158 Dumeril's clam ...
XP_023933046  86 NWADHEDVWTIMLKKDLIYansrkhdalnrHPTLQSKMRAILLDWLIEVCEVYrLHRETFYLSLDFLDRYLTVqtn-vqK 164 Lingula anatina
O15995       120 HWDDLPEVWTIMTRKEALCprkhd--clksHPSLGERMRAILLDWLIEVCEVYrLHRESFYLAADFVDRYLAAken-vpK 196 Hemicentrotus p...
EEN50328     111 NWASSRELWSPMLEKEALYnrdhn--ylnrHPGLAPRMRAILLDWLIEVCEVYrLHRETFYLAQDFIDRFLSTerd-lpK 187 Florida lancelet
EDV25452       2 SWADRKEVWQVMIENDNNFkrspd--cfdrHPNLVPNMRGILLDWMMEVCESFkMQRETFYMAMDYLDRYLSLsdn-ilK 78  Trichoplax adha...
KJE90681     246 HKNQIAEIYDWLKSREEHYvpasr-nfytkHPTIIPRMRAILIDWMKEVCEEYgMHRETFHLAAEFVDRYLHSsrvavdK 324 Capsaspora owcz...
RWS27716      15 SWANSEEVWELMHRKDKSQarnal--mlqrHPGLQPRMRSILLDWLTEVCEVYrLHRETNYLAIDFIDRYLSSqtq-vpK 91  Leptotrombidium...

Feature 1                   #   #####   ##                #  ##  ##  ##
1W98_B        91 TLLQLIGISSLFIAAKLEEIYPPKLHQFAYVTDGACsGDEILTMELMIMKALKW 144 human
P54733       403 THLQLIGITCLFVAAKVEEIYPPKIGEFAYVTDGACtERDILNHEKILLQALDW 456 fruit fly
O01501       304 DNFQLVGTAALFIAAKYEEIYPPKCIDFAHLTDSAFtCDNIRTMEVLIVKYIGW 357 Caenorhabditis elegans
CCI61378     159 QVLQLIGISALFIAAKLEEIYPPKLAEFAYVTDGACtENEILDQELVMLKALKW 212 Dumeril's clam worm
XP_023933046 165 HQLQLLGITCLFIAAKLEEIYPPKLSEFAYVTDGACtENQILCMELVVLKALNW 218 Lingula anatina
O15995       197 TKLQLIGITSLFVAAKLEEIYPPKLHEFAYVTDGACtDDQILDQELIMLMTLNW 250 Hemicentrotus pulcherrimus
EEN50328     188 HRLQHIGITALFIAAKLEEIYPPKVTEFAYVTDGACtDEEILDMELVLLKALNW 241 Florida lancelet
EDV25452      79 QKLQLIGTTCLFIAAKIEEIQPPQVSEFAYVTDSACsEDDIIKLELQLLQTLEF 132 Trichoplax adhaerens
KJE90681     325 NNLQLIGTTCMLIASKLEEVRPPVVADFAYVTDSACtALQIVENEMKVLMTLNW 378 Capsaspora owczarzaki ATCC 30864
RWS27716      92 QSLQLIGITCLFIASKIEEIYPPKLSEFAYVTDGACsDDEIIIKELVILKALNW 145 Leptotrombidium deliense

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