1JOW,1G3N,1BU2


Conserved Protein Domain Family
CYCLIN_vCyC_rpt2

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cd20518: CYCLIN_vCyC_rpt2 
Click on image for an interactive view with Cn3D
second cyclin box found in viral cyclin (v-cyclin)
v-Cyclin modulates host cell cycle progression and apoptotic signaling pathways. It forms an active kinase complex with cellular CDK6, a cellular cyclin-dependent kinase known to interact with cellular type D cyclins. v-Cyclin belongs to Cyclin D subfamily. It contains two cyclin boxes. This model corresponds to the second one. The cyclin box is a protein binding domain.
Statistics
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PSSM-Id: 410222
Aligned: 7 rows
Threshold Bit Score: 97.6243
Created: 26-Jul-2016
Updated: 25-Oct-2021
Structure
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Program:
Drawing:
Aligned Rows:
 
CDK interface
Conserved site includes 5 residues -Click on image for an interactive view with Cn3D
Feature 1:CDK interface [polypeptide binding site]
Evidence:
  • Structure:1JOW; Saimiriine gammaherpesvirus 2 v-Cyclin in complex with human CDK6, contacts at 4A
    View structure with Cn3D

Sequence Alignment
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Format: Row Display: Color Bits: Type Selection:
Feature 1        #  #            ##  #                                                        
1JOW_A    151 LATDFLIPLCNALkipedlWPQLYEAASTTICKALIQPniALLSPGLICAGGLLTTIEtdntnc-rpwtcYLEDLSSILN 229 Herpesvirus saimiri
1G3N_C    150 LATDVTSFLLLKLvggsqhLDFWHHEVNTLITKALVDPltGSLPASIISAAGCALLVPanvipqdthsggVVPQLASILG 229 Human gammaherpesv...
Q9J2H1    150 LPTDAIGPTLFKSgftkeqLFALHSQVVESVHKAIVNPatGGLPPSLVAAACALFSLGaa--------apPPARLAEAVG 221 Rhesus monkey rhad...
O40946    150 LATDVTSFLLLKLlggsqhLDFWHHEVNTLITKALVDPktGSLPASIISAAGCALLVPanvipqdthsggVVPQLASILG 229 Human herpesvirus 8
1BU2_A    130 LATDFLIPLCNALkipedlWPQLYEAASTTICKALIQPniALLSPGLICAGGLLTTIEtdntnc-rpwtcYLEDLSSILN 208 Herpesvirus saimir...
AGY30759  149 VATDVTACLLYRLdpvpdqYSAWHRATNSLIDRALVDPraGTLRASVLSAACCALAAStletpsgltsdeILQRLAAILS 228 Retroperitoneal fi...
Q77Q36    150 LATDVTSFLLLKLlggsqhLDFWHHEVNTLITKALVDPktGSLPASIISAAGCALLVPanvipqdthsggVVPQLASILG 229 Human gammaherpesv...
Feature 1                          
1JOW_A    230 fSTNTVRTVKDQVSEAFSLYD 250 Herpesvirus saimiri
1G3N_C    230 cDVSVLQAAVEQILTSVSDFD 250 Human gammaherpesvirus 8
Q9J2H1    222 vSAATLAAAAESVATTLREFD 242 Rhesus monkey rhadinovirus H26-95
O40946    230 cDVSVLQAAVEQILTSVSDFD 250 Human herpesvirus 8
1BU2_A    209 fSTNTVRTVKDQVSEAFSLYD 229 Herpesvirus saimiri (strain 11)
AGY30759  229 rEVVELKGARELVTSILATVT 249 Retroperitoneal fibromatosis-associated herpesvirus
Q77Q36    230 cDVSVLQAAVEQILTSVSDFD 250 Human gammaherpesvirus 8

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