2W96,3G33


Conserved Protein Domain Family
CYCLIN_CCND_rpt1
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cd20515: CYCLIN_CCND_rpt1 
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first cyclin box found in cyclin-D (CCND) family
The CCND family includes three mitogen-induced D-type cyclins, CCND1, CCND2 and CCND3, which function as regulatory subunits of the cyclin-dependent kinases CDK4 and CDK6, that drive progression through the G1 phase of the cell cycle. Members in this family contain two cyclin boxes. This model corresponds to the first one. The cyclin box is a protein binding domain.
Links
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Statistics
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PSSM-Id: 410219
Aligned: 17 rows
Threshold Bit Score: 226.412
Created: 12-Apr-2019
Updated: 25-Oct-2021
Structure
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Program:
Drawing:
Aligned Rows:
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CDK interfaceD-type cyclin
Conserved site includes 13 residues -Click on image for an interactive view with Cn3D
Feature 1:CDK interface [polypeptide binding site]
Evidence:
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Sequence Alignment
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Format: Row Display: Color Bits: Type Selection: 
Feature 1                                                #                                       
2W96_A         5 LLCCEVETIrraypd-----------anllndRVLRAMLKAEETCapsvs-yfkcvQKEVLPSMRKIVATWMLEVCEEQk 72  human
3G33_B        17 LLCCEGTRHapragpd---------prllgdqRVLQSLLRLEERYvpras-yfqcvQREIKPHMRKMLAYWMLEVCEEQr 86  human
NP_001087887   5 LLCWEPETElraqsd-----------pvllqsRVLMKLLELEERYipsas-yfycvQTHLQPYMRRMLTSWMLEVCEDQk 72  African clawed ...
EFX84986       6 LLCADACPEvmpvaard--------paimtdrRVLQQLLRLEMFSvpssdyfaptsTSELQPYMRRVVTTWMLEVTEEQn 77  common water flea
XP_006012922   7 LLCLEVGDLpraqrd-----------pvlletRTLWKLLQVEGRYlpsas-yfqnvQREIQPGMRKVLTGWMLEVCEEQd 74  coelacanth
KPM11292       5 LLCVESDTIpsaifds----------aivdddRTLSNLITIEERYlitgs-yfkclQTDLTSSNRCELATWMLEVCEAEn 73  Sarcoptes scabiei
EDV26611       3 LLCSEGFEKqaykdp------------vlqkeRVLQNLLKLEENYlpnrd-yftnvQREIKPFMRCMVTNWMLDVCHGEn 69  Trichoplax adha...
XP_013410672   5 LLCCESGVEtfenikray-----edpvllkdnRVLETLLRTEERYlpsas-yfkcvQTDIKPFMRKMVATWMLEVCEEQk 78  Lingula anatina
NP_001158492   9 LLCFEVDQIkrayedp----------vllkdnRVLENLLSSEDKYtpsfg--yfkwQTDLKDFMRKMVATWMLEVCEEQq 76  Saccoglossus ko...
NP_001006017   3 LFCHERADLnssspvksapirafrdavltrdtRVLQNLLSLEKPNisgkh--iagaESEELLRMRKILTGWMLQVCEEQk 80  zebrafish

Feature 1                                                 ## #  # ##                #  ##      ##
2W96_A        73 ceEEVFPLAMNYLDRFLSLep--vkKSRLQLLGATCMFVASKMKEtiPLTAEKLCIYTDNSIrPEELLQMELLLVNKLKW 150 human
3G33_B        87 ceEEVFPLAMNYLDRYLSCvp--trKAQLQLLGAVCMLLASKLREttPLTIEKLCIYTDHAVsPRQLRDWEVLVLGKLKW 164 human
NP_001087887  73 cgEDVFPLAVNCLDRFLSLvp--veKRRLQLLGSTCLFLASKLREttPMTAESLCMYSDYCFtDKELLAMELLVLNKLKW 150 African clawed ...
EFX84986      78 ceEQVFPLAVNLLDRFLALeaavlqRCQLQLLGCVCLLTASKLRQcrPIGVDLLVYYTDYSVtPAQIRVWEMLLLGKLGW 157 common water flea
XP_006012922  75 -yEEIFPLAVNCLDRFLSLis--leKSQLQLLGSTCLFLASKLKEtnPLMAETLCAYSDFSFtYQELKSMEVVVLKRLKW 151 coelacanth
KPM11292      74 cqCEVFPLSMNLLDRFLALfk--irKSQLQLLGSVCLFIASKLIQtrPISPQKLVYYTDWSIkLEELTDWELLVLSKLKW 151 Sarcoptes scabiei
EDV26611      70 cnDKVFPLAVNYLDRFLSMvs--irKIRLQLVGSVCLFLASKLKDriPLTAEKLCSWTDYSVtCQELLDWELLLLEKLKW 147 Trichoplax adha...
XP_013410672  79 ceEEVFPLSMNYLDRFLSIvn--trKNRLQLLGAACMFLASKLKEtiPLTAEKIVIYTDNSIsYQELLDLELLVLQKLKW 156 Lingula anatina
NP_001158492  77 ceEEVFTLSMNYVDRFLSVtq--mkKKYLQLLGAACMFLASKLKEtlPLTAEKLCIYTDHSItCDELLDMELLVLTKLKW 154 Saccoglossus ko...
NP_001006017  81 ceEEVFPLAVHYLDRYMSQsa--vrPCHLQLLGSVCMFLASKLREtvPLSAETLSIYTDHACsVPEILQWEVLLVSHLQW 158 zebrafish

Feature 1        #
2W96_A       151 N 151 human
3G33_B       165 D 165 human
NP_001087887 151 D 151 African clawed frog
EFX84986     158 D 158 common water flea
XP_006012922 152 D 152 coelacanth
KPM11292     152 D 152 Sarcoptes scabiei
EDV26611     148 D 148 Trichoplax adhaerens
XP_013410672 157 D 157 Lingula anatina
NP_001158492 155 D 155 Saccoglossus kowalevskii
NP_001006017 159 D 159 zebrafish

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