4Y72,2JGZ


Conserved Protein Domain Family
CYCLIN_CCNB1-like_rpt1
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cd20507: CYCLIN_CCNB1-like_rpt1 
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first cyclin box found in cyclin-B1 (CCNB1)-like family
The CCNB1-like family includes two B-type cyclins, CCNB1 and CCNB2, both of which are essential for the control of the cell cycle at the G2/M (mitosis) transition. Members in this family contain two cyclin boxes. This model corresponds to the first one. The cyclin box is a protein binding domain.
Links
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Statistics
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PSSM-Id: 410211
Aligned: 42 rows
Threshold Bit Score: 180.803
Created: 12-Apr-2019
Updated: 25-Oct-2021
Structure
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Program:
Drawing:
Aligned Rows:
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CDK interfaceB-type cyclin
Conserved site includes 24 residues -Click on image for an interactive view with Cn3D
Feature 1:CDK interface [polypeptide binding site]
Evidence:
  • Comment:CDK = cyclin-dependent kinase
  • Structure:4Y72; Homo sapiens CCNB1 in complex with CDK1, contacts at 4A
    - View structure with Cn3D
  • Structure:2JGZ; Homo sapiens CCNB1 in complex with phospho-CDK2, contacts at 4A
    - View structure with Cn3D
Download Cn3D for Viewing 3D StructureScroll to Sequence Alignment Display
Sequence Alignment
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Format: Row Display: Color Bits: Type Selection: 
Feature 1          ##  ##  ##  #                                                                 
4Y72_B         7 SSEYVKDIYAYLRQLEEEQAVRPKYLlg-----rEVTGNMRAILIDWLVQVQMKFrLLQETMYMTVSIIDRFMQNns--- 78  human
CBZ41115     144 GGPYVNEIYDYTKYLEHAYAVKPRFLde----hkEVSHKMRTILVDWIVQVHQRFkLQNETLHLTVAIMDRYLSKvqd-- 217 Oikopleura dioica
OMJ72800      50 VSEYSREIIQNLKQEELLYEAEKDFMkh----qpDITSNSRAILINWLVSVHRYLkLLLETFYIAISLVDRFLQKks--- 122 Stentor coeruleus
XP_004037568  76 VSEYQQEIFKYLQKQEQLNKIDYTYLlh----qpEITSQMRTVLVDWLVEIHLQFrLLPETLHLTIYIIDKYLSIkk--- 148 Ichthyophthiriu...
XP_025412607 172 VGAYSKQIFEYLMTLEDKSIIKPDYLan----hkYITPSNRSVVVDWLVEVQQEFqIMQESLYMAVGILDRYLQEnkn-- 245 yellow sugarcan...
Q9SA32       140 VAEYVDDIYQFYWTAEALNPALGHYLsa----haEVSPVTRGILINWLIEVHFKFdLMHETLYLTMDLLDRYLSQvp--- 212 thale cress
PAA60845     124 VSAYVKDIFTYLQQLEISAAAVRPDFlqsp-srlQITPRMRTILCDWLVQVHQRYtLLPESLYLTYHIIDAFMSSdagas 202 Macrostomum lig...
Q10653        75 CLAMADDIYKYLVHHEKKYLLEECFMeg-----gEPTPKMRRILVDWLVQVHVRFhLTPETLHLTVFILDRMLQKkv--- 146 Caenorhabditis ...
P24868       206 VSEEVNDIFDYLHHLEIITLPNKANLyk-----hKNIKQNRDILVNWIIKIHNKFgLLPETLYLAINIMDRFLCEev--- 277 Saccharomyces c...
CEM28556     266 CSEYAKQIYDDLVRKSAQFHLRARHGyfeggsqpEVSSVMRTILVDWMVEVHKRFkLKQETLHIAITIMDRYFESka--- 342 Vitrella brassi...

Feature 1                      ##  #####  ###                #  ##  ##  ##
4Y72_B        79 vpKKMLQLVGVTAMFIASKYEEMypPEIGDFAFVTDntYTKHQIRQMEMKILRALNF 135 human
CBZ41115     218 lpRKEMQMIGLTSMLLASKYEEIymPDLGDFEFICDnaYTRDDFKATELEILDVLQC 274 Oikopleura dioica
OMJ72800     123 vtKYQLQLLGISALFLASKYEEIypPEFSKFLKVCEnaYTKAQIVLMEKEILKALDF 179 Stentor coeruleus
XP_004037568 149 ieKSQLYLLGITSLYISSKYEEIypPSIEQFIETCD--ISQKEILVFEGDILKNLNF 203 Ichthyophthirius multifiliis
XP_025412607 246 vaRNKLQLLGATSLLLGCKYEEIyvPEITDFIYLSDnaFTKDEVKSSLVDVFRTINY 302 yellow sugarcane aphid
Q9SA32       213 ihKNEMQLIGLTALLLASKYEDYwhPRIKDLISISAesYTREQILGMERSMLKQLKF 269 thale cress
PAA60845     203 vkKSEFQLIGVSAMLLASKYEEIypPNVADFVYITDqaFTAAEIRATEQRLLKQLNF 259 Macrostomum lignano
Q10653       147 tsKADLQLLGISAMFVASKFEEVylPDIHDYEFITEntYSKKQILAMEQTILNSLNF 203 Caenorhabditis elegans
P24868       278 vqLNRLQLVGTSCLFIASKYEEIysPSIKHFAYETDgaCSVEDIKEGERFILEKLDF 334 Saccharomyces cerevisiae S288c
CEM28556     343 lpREHLQLLGASCLLIAAKYEEIfaPEVNDVVFVADnaFSAQQLRDFEMQLLDVLKF 399 Vitrella brassicaformis CCMP3155

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