5IF1


Conserved Protein Domain Family
CYCLIN_CCNA_rpt2
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cd20505: CYCLIN_CCNA_rpt2 
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second cyclin box found in cyclin-A (CCNA) family
The CCNA family includes two A-type cyclins, CCNA1 and CCNA2. CCNA1 may primarily function in the control of the germline meiotic cell cycle and additionally in the control of mitotic cell cycle in some somatic cells. CCNA2 controls both the G1/S and the G2/M transition phases of the cell cycle. Members in this family contain two cyclin boxes. This model corresponds to the second one. The cyclin box is a protein binding domain.
Links
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Statistics
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PSSM-Id: 410209
Aligned: 14 rows
Threshold Bit Score: 139.35
Created: 12-Apr-2019
Updated: 25-Oct-2021
Structure
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Program:
Drawing:
Aligned Rows:
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CDK interface
Conserved site includes 3 residues -Click on image for an interactive view with Cn3D
Feature 1:CDK interface [polypeptide binding site]
Evidence:
  • Comment:CDK = cyclin-dependent kinase
  • Structure:5IF1; Homo sapiens CCNA2 in complex with CDK2, contacts at 4A.
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Sequence Alignment
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Format: Row Display: Color Bits: Type Selection: 
Feature 1           ##  #                                                                        
5IF1_B       142 PTVNQFLTQYFLHqqpanCKVESLAMFLGELSLIDADPYlKYLPSVIAGAAFHLALYTvtgqsWPESLIRKTGYTlESLK 221 human
8134359      342 PTTNQFLLQYLRRqg-vcVRTENLAKYVAELSLLEADPFlKYLPSLIAAAAFCLANYTvnkhfWPETLAAFTGYSlSEIV 420 human
P24861       302 PTINWFTDTYAKMad-tdETTKSLSMYLSELTLVDADPYlKYLPSTIAAASLCLANITlgsepWPSSLAKESKYEiSEFS 380 common limpet
XP_004998950 436 CTALTFLVRFIHAas-atPPSHCLALYLAELSLLLGNKFiQYLPSVKAAAAICLSQHTfarpvWTPTFERYCRLSpEEVQ 514 Salpingoeca ros...
ADL62716     339 PTINYFLQRFCHVgq-vpEIIEYLAKYMCELSLVEGDQYlRFLPSVVAAAAVCLANHTggfipWDEKLATSSGYSyEDIQ 417 Tachypleus trid...
EFX71416     325 PTSNYFLQRYIQTsr-ssETCLHLASYLCELTLMETEPYlHHLPSVVAASSVALARLAcgneiWPSHVQASSGYSlEQLM 403 common water flea
OXU29124     329 PTPLAFLMEYCISnn-lsEKTQYLAMYLCELSLLEADPYlQYLPSHLAASAIALARHTlreevWPHELELSSGYSlQDLK 407 Trichomalopsis ...
XP_005707373 248 ASSYQFASIFGSWgn-lnEVVKSISFFLCDLSLVDFSLS-KYLPSDIATAAVCLARLScneclWDDMLAELTHKRmEDVL 325 Galdieria sulph...
XP_021955549 437 PTAHSFGVAYCSLln-lgDPGRSLVSYLVDLSLMEGNVFlKYVPSIVAGSAVALARFVfhnkfYDADLRRYCRHRkRTLI 515 Folsomia candida
P04962       294 PTTNWFCEDFLKScd-adDKLKSLTMFLTELTLIDMDAYlKYLPSITAAAALCLARYSlgiepWPQNLVKKTGYEiGHFV 372 Atlantic surf clam

Feature 1                                       
5IF1_B       222 PCLMDLHQTYlkapqHAQQSIREKYKNSKYH 252 human
8134359      421 PCLSELHKAYldiphRPQQAIREKYKASKYL 451 human
P24861       381 ECLQEMYQTYlnapnHPQQAIREKYKSSKYQ 411 common limpet
XP_004998950 515 PCLNDMFEAMtsaphLEYQAIREKYMERRFH 545 Salpingoeca rosetta
ADL62716     418 ECVRCLYDSIckaqsSPQQAIREKYKSSKNY 448 Tachypleus tridentatus
EFX71416     404 PCIKDLHATWvqapsSPQQAIREKYKAEKWH 434 common water flea
OXU29124     408 ECINHLQRTFknapnLPQQAIQEKYKSNKYG 438 Trichomalopsis sarcophagae
XP_005707373 326 PCLLTLRRVWeecaySKLQAVRVKYHSPKYH 356 Galdieria sulphuraria
XP_021955549 516 PCVRDLHEAFfmaptKGQTSLYEKYQAVRYC 546 Folsomia candida
P04962       373 DCLKDLHKTSlgaesHQQQAVQEKYKQDKYH 403 Atlantic surf clam

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