1QMZ


Conserved Protein Domain Family
CYCLIN_CCNA_rpt1
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cd20504: CYCLIN_CCNA_rpt1 
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first cyclin box found in cyclin-A (CCNA) family
The CCNA family includes two A-type cyclins, CCNA1 and CCNA2. CCNA1 may primarily function in the control of the germline meiotic cell cycle and additionally in the control of mitotic cell cycle in some somatic cells. CCNA2 controls both the G1/S and the G2/M transition phases of the cell cycle. Members in this family contain two cyclin boxes. The model corresponds to the first one. The cyclin box is a protein binding domain.
Links
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Statistics
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PSSM-Id: 410208
Aligned: 24 rows
Threshold Bit Score: 215.575
Created: 12-Apr-2019
Updated: 25-Oct-2021
Structure
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Program:
Drawing:
Aligned Rows:
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CDK interfaceA-type cyclin
Conserved site includes 23 residues -Click on image for an interactive view with Cn3D
Feature 1:CDK interface [polypeptide binding site]
Evidence:
  • Comment:CDK = cyclin-dependent kinase
  • Structure:1QMZ; Homo sapiens CCNA2 in complex with CDK2, contacts at 4A.
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Sequence Alignment
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Format: Row Display: Color Bits: Type Selection: 
Feature 1         ### ##  #                                                                       
1QMZ_B          4 DYHEDIHTYLREMEVKCKPkvgym----kkqpDITNSMRAILVDWLVEVGEEYKlqNETLHLAVNYIDRFLSSmsvlrgk 79   human
XP_019850867  152 EYAQDILSHMRQSEIQYHPmidym----tkqyDITNIMRCILVDWLVEVCDEFHllPETLFAAVAYVDRYLSQvsvprsk 227  Amphimedon qu...
XP_004347466  266 EYMPEVMLHLREREIAVRPapsym----qrqnDINGNMRAVLVDWLVDVALEYRlkPETLYLAIGYIDRFLSElaiarsk 341  Capsaspora ow...
RDD42486      255 VYADDIHSYLRKAEYFHRPkydym----erqcDVNGTMRSILVDWLVEVSEEYKlrERTLYLAISYIDRFLSAmsvrrsk 330  Trichoplax sp...
EME30853      112 EYKDDVFRVLLSCEKRCFPeasyvddmkatqsEISPNMRAILMDWLVEVAEEYKlsNETLHLACNYIDRFLSRcsvskkn 191  Galdieria sul...
XP_004998950  304 EYVEKVMTYLRHLEKKFRPhagym----grqrDINHNMRSILVDWLVEVTEEYRlqLQTLYIAVGYIDRFLSNmavqrsk 379  Salpingoeca r...
PRW33036     1029 TYVNDIFEYLRESELKRRPtttym---esvqsDINPMMRSILLDWLVEVGMEYRltSDTLFLSAAYIDRYLSLvdvkrnr 1105 Chlorella sor...
XP_005837981  103 EYAIEIFEHLINTERRLSPsfnym---eqvqhDINPTMRGILIDWLVEVAEEYKlsSENLFLSTNYVDRFLSVmpvlrsk 179  Guillardia th...
PRP87684      120 QYSADIYRNTLRSEIQYQPkfylp---savhqELTPKMRSILIDWLVEVAIEFKlnSETLFLAVNYIDRFLSTqsvpksk 196  Planoprotoste...
PNW85728      142 HYAGAIFEYLREAELMRRAipdyl----dsqpEINSKMRSILVDWLVEVSEEYRmvPDTLYYAVNFLDRVLTLqrvsrsq 217  Chlamydomonas...

Feature 1                   #  #####   ##            ##  #  ##  ##  ##
1QMZ_B         80 LQLVGTAAMLLASKFEEIyppEVAEFVYITDDTYtKKQVLRMEHLVLKVLTF 131  human
XP_019850867  228 LQLVGVTCLYLSAKFEEIhppEISEFAYITDDTYtKKQIVKMEHEILNVLSY 279  Amphimedon queenslandica
XP_004347466  342 LQLLGIACMFVAAKFEEIfppNVHDFFEIADRTYeVEQIIRMEQAVLKTLRF 393  Capsaspora owczarzaki ATCC 30864
RDD42486      331 LQLVGTAALFIAAKFQEIyppDCAEFAYITDDTYnIKQVLKMESLMLKVLSF 382  Trichoplax sp. H2
EME30853      192 LQLLGVVCLLVASKYEEKyppHVDEFVYITDNTYtKEEVLSMEMLVMKVLKF 243  Galdieria sulphuraria
XP_004998950  380 LQLVGVTCMLLAAKYEEIyppSVNEFVYITDNTYrREQVLKMEHVVLKVLRF 431  Salpingoeca rosetta
PRW33036     1106 LQLVGVTAMLVASKYEEIyapQVEEFCYITDNTYtREQVLEMEREVLRVLDF 1157 Chlorella sorokiniana
XP_005837981  180 LQLVGVTCMLIASKYEEInapQVEDFVYITDSTYsAQEVLQMEVVILHALKF 231  Guillardia theta CCMP2712
PRP87684      197 LQLLGVTCMMIAAKFEEVwppSVEDFIFISDNCYtKQEIFAMEVKILNELKF 248  Planoprotostelium fungivorum
PNW85728      218 LQLVGITCMWIAAKYEEIyppNVSEFSYITDNTYsREQLVAMEEEVLRQLKY 269  Chlamydomonas reinhardtii

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