Conserved Protein Domain Family
C58_YopT
?
cd20498: C58_YopT 
peptidase C58 domain of the YopT subfamily, including Yersinia pestis YopT and related proteins
This subfamily includes the plague organism Yersinia pestis cysteine protease YopT, an outer membrane protein. Y. pestis can disarm the host immune response by interfering with cell-signaling pathways; YopT cleaves post-translationally modified Rho GTPases near their carboxyl termini, releasing them from the membrane. This leads to the disruption of the actin cytoskeleton in host cells. YopT's proteolytic activity is dependent upon the invariant C/H/D residues conserved in the C58/YopT family peptidase domain.
Links
?
Statistics
?
PSSM-Id: 410779
Aligned: 33 rows
Threshold Bit Score: 141.368
Created: 20-Jun-2019
Updated: 25-Oct-2021
Structure
?
Aligned Rows:
Download Cn3D
 
catalytic site
Feature 1: catalytic site [active site], 3 residue positions
Conserved feature residue pattern:C H [DE]Click to see conserved feature residue pattern help
Evidence:
  • Comment:these 3 catalytic residues form an active site triad
Scroll to Sequence Alignment Display
Sequence Alignment
?
Format: Row Display: Color Bits: Type Selection: 
Feature 1                                                 #                                      
O68703       111 GNINFKFAQTKGAfl-hKIIKHSDta------------sGVCEALCAHWIRSHAQg---------qSLFDQLYVGg---- 164 Yersinia pestis
RLT95098      15 SGCYIEYSQGNRGth-dIIKQSPLta------------dGICQALSAKWIAQHANd---------dSLWNWLFLPg---- 68  Ketobacter sp.
WP_029247321  20 GGSYIPYSQCVPPts-tLIESMPQts------------dGICKALSAKWIVEHSNg---------sSLFNWLCTPg---- 73  Schlesneria pal...
WP_015487003  20 GHCTWDFSQGFPL----HFIQAPTg-------------nGICMGLSCHWIKYHALd---------dSLVTHLGAYripn- 72  Thalassolituus ...
WP_094708468  20 GLCTWDFSQGYPL----HFIQGPVg-------------nGICMGLSCHWVQYHALd---------dSLVNHLGAVwnpn- 72  Hahella sp. CCB...
WP_108733647  16 GQLIWKFSQGDYSk---ITKKHPHtk------------gGICEALSVSWVSKALQsglkaalttngDIDKTKIAVvaqrf 80  Microbulbifer s...
WP_020413014  12 GVKTWGFSQSSPRa---YIHYFRFgk------------fGICASLAAHWIKTNALdd--------kSLPDKLGLTprvhn 68  Microbulbifer v...
RLT89366      35 GACTKIFVQGGTPn--eAKGKTQMaqlgvgkyykpqgmhGVCKAMSTFWIANHANd---------eDFWGWLIQDgfvkv 103 Alcanivoracacea...
RLT90598      14 GICTWDLSQSLPPvqrmARMGGVDmg------------qGICLGLASHWIRYHAWd---------dSLVNHLGGVainn- 71  Alcanivoracacea...
RLT96011      16 GQVLVLYRQGLDIr---VKSGGSLvn------------gGWCLAMSIQWIIKTANe---------qSFWGWFKPPavacp 71  Ketobacter sp.

Feature 1                                                                                        
O68703       165 ------------------rKGKFQIDTLYSIKQLQIdgcka-------------------------dvdqDEVTLDWFKK 201 Yersinia pestis
RLT95098      69 -------------------TTTVNKAAVVQLMHNYVdassgarftslgnp-------ttkykytlgltyqDYVTDRYLEL 122 Ketobacter sp.
WP_029247321  74 -------------------TLNVRQSAVANLMLNFMdgtettgafknrswfrkgsmrkeyksrqnhlsrqTFMTDKYLQL 134 Schlesneria pal...
WP_015487003  73 ----------------trtFIPFNHNEYQRISQWQNnlat--------------------------fpdwRMGYQNWFRN 110 Thalassolituus ...
WP_094708468  73 ----------------triYKPFNHHELQRISAWQRsltr--------------------------fpdwVMGYQAWLRN 110 Hahella sp. CCB...
WP_108733647  81 --------------asmyrFKFANGTEGRPSTSYEM----------------------------------IEETKQYLES 112 Microbulbifer s...
WP_020413014  69 ag-----------afsfrtYRSLNIGELIKVGRDFRtwtyg-------------------------ggrqGLNIENWLIN 112 Microbulbifer v...
RLT89366     104 --------------ssaamLIDAHKQSKANGNQTLWen------------------------------niLKTVGIILQG 139 Alcanivoracacea...
RLT90598      72 ----------------ghsFIPLDLRLLAHIKQCQWqwr-----------------------------grLDDALIWLGS 106 Alcanivoracacea...
RLT96011      72 sladrnasagvgapfvalkTIMQHDAKLVKQKEYLIqsg-----------------------------lnPTAVMNWYAP 122 Ketobacter sp.

Feature 1                                                                                        
O68703       202 Ngisermi---erhcllRPVDVTGTTESEgl---------dqLLNAILDTHGIgy--------------gYKKIHLSGQm 255 Yersinia pestis
RLT95098     123 Ydvkrrqm---vsasflGNQNARIGTGANgfcl------anrLHKKFLNTLGGs----------------YVLIVIKGQh 177 Ketobacter sp.
WP_029247321 135 Yglkrrn-----glrgvGMNDNPISVGANgsal------anmFDSRYLNTKGEt----------------YMTIGILGDa 187 Schlesneria pal...
WP_015487003 111 Qgi-------------gIHSSTRIPMNSGa------------LKTELERIQGG-----------------HVLIILDGQr 148 Thalassolituus ...
WP_094708468 111 Ngl-------------gIHSNNRIPMNSNa------------LKAELDRIKGG-----------------YALIILSGQn 148 Hahella sp. CCB...
WP_108733647 113 Qg---------------FRNVGQAGSGIVlkkq------spsLEDQFTTSFGVlesmdc-----fkqqsnTLSCILRSAg 166 Microbulbifer s...
WP_020413014 113 QglhkedrwsssaiavaLNNMVVIQPGQPvppvqpippintsLVNALRSLRDA-----------------YGYITFSGRr 175 Microbulbifer v...
RLT89366     140 Hsn------------amIFEDVDTGATPYgra--------vqMVNRILKGRWG-----------------YRSISIHREg 182 Alcanivoracacea...
RLT90598     107 Pvndiik----vrtslnIPVRMNIGRGANafqq------tslPGSRNTNTRGRvvnwaglsddlekvsgaYAMIVLHGAg 176 Alcanivoracacea...
RLT96011     123 K----------------ITFETPCQRNQNgdslq---qnvvsGETLAQMCTRTs---------------gYKTISIYGDs 168 Ketobacter sp.

Feature 1              #                    #                                               
O68703       256 ----sAHAIAAYVNek-----sGVTFFDPNFGEFHFSDkEKFRKWFTNSFWGNsmyhyplGVGQRFRVLTFDSKE 321 Yersinia pestis
RLT95098     178 nnsqvGHAMAAYVGs------eDVTFFDPNYGEFWFPSqDKFTTWFTQYWSMSey----dKIFKDFYLVPYGKAV 242 Ketobacter sp.
WP_029247321 188 ----gGHALAGYCAg------kEVILFDPNYGEFYFPSyDMSYPWIQYFYVASdy---isDFDTFYMLGYAKDAT 249 Schlesneria paludicola
WP_015487003 149 a--ngSHAISAYIGqn----geDVCFFDPNYGEYWFQNrNDFFFFLHLFSNFCygh--nhQRHTGFNRYEIVRLY 215 Thalassolituus oleiv...
WP_094708468 149 t--rdSHAIAAYIGqd----geDVCFFDPNYGEFWFQDrDDFFFFLHLFSNFVynr--nhRHNTGFNRYEVVRIY 215 Hahella sp. CCB-MM4
WP_108733647 167 s--gwGHAMAFRIEpta---dkASYFFDPNKGEFKFLKyAQFRKWYEHYHSNNs------RYRTSRALGFDIFVH 230 Microbulbifer sp. A4B17
WP_020413014 176 ----aGHAVAAWVAddrvnsdiGALFFDPNYGEYRFATkGDFLNFFDAYYRHAymr-gwiQFRSDWSVDAYINRV 245 Microbulbifer variab...
RLT89366     183 ----gGHAMAAWVGq-------DVCFMDPNYGEFWFETvDGFRNWFIDFWVTS-------GYATKYDVDCQVLSY 239 Alcanivoracaceae bac...
RLT90598     177 ----gGHAFAAWIGgr----geDACFFDPNFGEYWFEDkQNFFRFLRLFAQNLyn---arMGMDRYEIQPLARRV 240 Alcanivoracaceae bac...
RLT96011     169 ----gAHAMAARVId------dTVVFMDPNYGEFYFPDfTAFSKFMKGFWTKF-------KYANKFSKLVAVTSF 226 Ketobacter sp.

| Disclaimer | Privacy statement | Accessibility |
NCBI Home NCBI Search NCBI SiteMap