1UKF


Conserved Protein Domain Family
C58_YopT-like
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cd20497: C58_YopT-like 
peptidase C58 domain of YopT-like proteins, including Pseudomonas avirulence AvrPphB
This subfamily includes the C58 peptidase domain of the Pseudomonas avirulence (Avr) protein AvrPphB which is homologous to Yersinia effector known as YopT; both are involved in bacterial pathogenesis. These proteins have a papain-like fold and a distinct substrate-binding site. The proteolytic activity of AvrPphB is essential for autoproteolytic cleavage of an AvrPphB precursor as well as for eliciting the hypersensitive response in plants. Also included is the Ralstonia solanacearum type III effector protein RipT, a YopT-like cysteine protease. All of these proteolytic activities are dependent upon the invariant C/H/D residues conserved in the C58/YopT family peptidase domain.
Links
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Statistics
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PSSM-Id: 410778
Aligned: 21 rows
Threshold Bit Score: 143.642
Created: 20-Jun-2019
Updated: 25-Oct-2021
Structure
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Program:
Drawing:
Aligned Rows:
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catalytic site
Conserved site includes 3 residues -Click on image for an interactive view with Cn3D
Feature 1: catalytic site [active site], 3 residue positions
Conserved feature residue pattern:C H [DE]Click to see conserved feature residue pattern help
Evidence:
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Sequence Alignment
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Format: Row Display: Color Bits: Type Selection: 
Feature 1                               #                                                        
1UKF_A         2 LSDFSVASRDVNHn-------NICAGLSTEWLVMSSDGd---AESRMDHLDy-------nGEGQSRGSERHQVYNDALRa 64  Pseudomonas sav...
WP_084402727 131 LSDYQVASADLNRa-------NICAGLSTEWLRLKGAGt---ASSRLDTLAp-------gNAAYDTAAMRHERYHHAIAh 193 Cupriavidus sp....
PWC84788      18 IQRLFPADHEVNS--------GICFGLSLEWIARHRSHkgetSKARIAYIDld------nTILHASIKQRLYGAELSHDl 83  Azospirillum sp...
PWE57084      44 QRDLAVADEEVSY--------GICVGLSAEWVARHKKYksegSAKRIAFIK---------SQAPSAIARQKAYLSVLTKs 106 Rhizobium album
KGE06382       9 YNMGQVADSVGQEig-----eGVCYGLSMEWLANRRSGaagqNADSLAALRspaalgraqNVQNNYVSYQQSIQSVSHDp 83  Burkholderia gl...
WP_081025870  90 APFEQASALAQVGel-----rAACVVFSAAWLHSIANVsl-tNHGRMEHFTq-------vETLEGISAQQRGYRQHELAi 156 Ralstonia solan...
Q9RBW5       139 VFNYRIAALNNANa------sQSCMGLAIQWLRLRDEEe---ASYRMEALDldha-sdiqNQYENAAGSVSGSREQREAg 208 Pseudomonas sav...
EKU26252     172 LNNYRVAELRGANa------gQACMGFAVQWLGVRGQGe---PASRILSLNadea-eniqDAYEKAAESAGGNREQREDa 241 Xanthomonas tra...
SBV52202     124 VFNYRVARLNNANa------sQSCMGFAIQWLQLRDQSh---ANVRMDQLDpgda-lvlqQQYEDTVAPVDGGREQREAa 193 Xanthomonas bromi
WP_119778108  49 KYPYSQDRLLKQSttdkdlleGICVALSDYWLYLMHKNpqqpPPERIAALKa--------KDLFKEAMDHQRKYSKDRAq 120 Oleomonas sp. K...

Feature 1                                                                                        
1UKF_A        65 alsn--------ddeapFFTASTAVIEd-aGFSLrrepKTVHASGgsaqLGQTVAHDVAQs----GRKHLLSLRFan--- 128 Pseudomonas sav...
WP_084402727 194 ahrs--------gaeepITEGAQAILRd-aGLRKigqsTTIYCSPy--rGLGAVAEPLAKs----NTRYLVSLRFqn--- 255 Cupriavidus sp....
PWC84788      84 dls-----------seqLGSRNQAMAQa--GFKIas-tKTEWVSAtnpeSVKEVMKAISTataspHTYHVVTMIFeqr-- 147 Azospirillum sp...
PWE57084     107 rssaf-------sgqttELDAALAFAEs--GMSAnladSTRFMRAaadeCLHPLYTHTGGh----NNYFLILLSFgk--- 170 Rhizobium album
KGE06382      84 s--------------vrTDMAITEIFRq-qGVQVs--rATDLFNGe---SMHALTRAPGD-----YVVGLIGFGT----- 133 Burkholderia gl...
WP_081025870 157 rgq----------grpySEWFAPAFQHygvGLGTd--vVVDVMSHee-qAMQNLANMFAQa----NSSHVFVIMRtn--- 216 Ralstonia solan...
Q9RBW5       209 -----------------RISARKTLLRs-qDLQPv--gEPSVFHAd---RQSTALQKIARd----GSVHLISLCFenng- 260 Pseudomonas sav...
EKU26252     242 -----------------RIAARQGILVs-rGLQPm---GQSAMFHv--sRQTDALAHIARe----RQACLVSLCFdrsg- 293 Xanthomonas tra...
SBV52202     194 -----------------RISARRTLLRd-qGLQPig-dAPIYRRE----ELSTALREIACn----GRAHLISLCFeanrg 246 Xanthomonas bromi
WP_119778108 121 fgpvvsrgiagarlglaYDPEKTTIMRmphDLIPg---NPIEQTPd--qIIQQMMRDIAGi----GSAISWSLRFang-- 189 Oleomonas sp. K...

Feature 1            #                       #                                                  
1UKF_A       129 -vqGHAIACSCEg---------sQFKLFDPNLGEFQSSRsa--aPQLIKGLIDHYNSln--------ydVACVNEFRVS 187 Pseudomonas sava...
WP_084402727 256 -geGHAIAVATSg---------nRTKLFDPNYGEYGAAPdq--vHGLLRSLAAHYSAqd--------ldLAAVNLHRVQ 314 Cupriavidus sp. ...
PWC84788     148 -gmAHATCCYKSggkaf--glgsHLYFFDPNFGEYKASSgs--vGDLFAGLVDRYRNfvkrdgstvdykVKEFVVQSIS 221 Azospirillum sp....
PWE57084     171 --dNHCIAAYHSsgklf--gygsHLYVFEPNFGEIKIAAsetavKGFFKALAEAYRTyadkdnvvdpkiLDRVTVVRLS 245 Rhizobium album
KGE06382     134 ---GHAITVHRParne----rdqRLTVFDSNMGEFKVSRrd--eEYFFDAMQARYNVig--------erFTHASAYSIP 195 Burkholderia gla...
WP_081025870 217 -gdNHAIATHQSg---------nHVHVFDPNHGEYRLRRse--lKDGLRSIIQAYSSrf---------pVPELRVIPAY 274 Ralstonia solana...
Q9RBW5       261 krvRHAITASSSe---------gSVNVFDPNYGEFSTTLpe--lPSMFQNLMTRYGSrlng-----hlqLESMVIQRVE 323 Pseudomonas sava...
EKU26252     294 krvRHAVATSSAg---------gNVSLFDPNYGEFSSSAag--lPDMFEGLMARYGSrmng-----yleLESMVIQEVK 356 Xanthomonas tran...
SBV52202     247 khvRHAITASSSh---------gTVSLFDPNYGEFSTTSag--lRSMFEALMARYDSglng-----hlqLESMTIQRVQ 309 Xanthomonas bromi
WP_119778108 190 -qgGHAIAGATTlqsqsenmhmqVTHLFDPNIGELVGSPrd--aKAMIEEIATFYTSdg--------liIESVRRTGAD 257 Oleomonas sp. K1...

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