6HV6


Conserved Protein Domain Family
C58_PaToxP-like

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cd20495: C58_PaToxP-like 
peptidase C58 domain of Photorhabdus asymbiotica toxin PaTox and LifA/Efa1-related large cytotoxin, and similar proteins
This subfamily includes the cysteine protease domain of Photorhabdus asymbiotica toxin PaTox, a large virulence-associated multifunctional protein toxin. This domain is similar to AvrPphB protease found in Pseudomonas syringae, a C58 protease. Mutation studies show that this domain enhances cytotoxic effects of the toxin, and therefore is essential for full PaTox activity. Also included in this family is the enteropathogenic Escherichia coli (EPEC) factor for adherence/lymphocyte activation inhibitor (efa1/lifA) gene which is strongly associated with diarrhea. Efa1/LifA proteins are important for A/E lesion formation efficiency in EPEC strains lacking multiple effectors. This domain contains the invariant C/H/D residues conserved in the C58/YopT family.
Statistics
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PSSM-Id: 410776
Aligned: 136 rows
Threshold Bit Score: 86.6442
Created: 19-Jun-2019
Updated: 25-Oct-2021
Structure
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Program:
Drawing:
Aligned Rows:
 
catalytic sitechemical
Conserved site includes 3 residues -Click on image for an interactive view with Cn3D
Feature 1: catalytic site [active site], 3 residue positions
Conserved feature residue pattern:C H [DE]Click to see conserved feature residue pattern help
Evidence:
  • Comment:these 3 catalytic residues form an active site triad

Sequence Alignment
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Format: Row Display: Color Bits: Type Selection:
Feature 1                                          #                                              
6HV6_A        180 ANKVVLTPQnlyl--------------kgkpSEALPESVLMGWALQss----qDAKLSKMLMGiyssnd----------- 230  Photorhabdus ...
WP_136403027  692 SKTLQFIPQdlllss-----------feypeGLCLGLSILQGLADDln----aNDIFAADIAAvsalqqnrldnt-lsva 755  Flavobacteriu...
WP_139824363 1232 KTITRLAPQsiyiglanpelspdspnniqpkKESVGLGLAYLSMLAkdsnqslKSKLLDGLLThghilardgegagiseq 1311 unicellular c...
WP_045984862 2247 NAQLHFAPQsmyvg------------ntdtqGKCAGLGQAYLYALSqgddagfKNTFLDGVFThsdivrnsatdgtvsqk 2314 Vibrio corall...
PAK92420     1634 GGQFIQASQgllgeg----------tglsaaGMCTGLSRIMATAMGqg----eEIHVLEHLRQairepe----------- 1688 Stenotrophomo...
KQN54199      345 GASLRFAPQtfllg-------------dsatGICEALSEAWLFTSAqndggilSKTLLDEVFLrsplttd---------- 401  Serratia sp. ...
WP_129373382  881 TTEVRHAPQslyvgvg---------kdgkpcGQCVGLSLGYLYSLSqsd--stKQKFLDGVFThsrivdnsss----svr 945  Leisingera sp...
OEY99691     1518 GGQFIPASQsllgeg----------mgmassGMCTGVSRIGVAAMGqg----eELHLLNQLRLairepg----------- 1572 Stenotrophomo...
WP_020407856 2211 DVRLRQAPQslylga----------gdnapnGRCVGIGLGYLHMLSqgtgsqaSEAFLDALVTsaaisdtmhqdrdistt 2280 Hahella gangh...
WP_125358309  382 GGQYFAVSQsllnvr-----------sggsmGWCTGLSRMMAMALGqg----kAMELVRNLRLalrrpd----------- 435  Stenotrophomo...
Feature 1                                                                            #            
6HV6_A        231 --itsnpLYKSLKELHANgnaskfna-------satsisniNVSNLATSEtklfpteISSVRVDAPKHTMLISKIknre- 300  Photorhabdus ...
WP_136403027  756 dtqlykqFSEQLRNLNRSvnavffdeke----tlfknagtaSVDQLATAItklpfqkDSRFLLVTPNHGMTLSLKg---- 827  Flavobacteriu...
WP_139824363 1312 eaqqssdFENLLASVEESplenadqpnsllkigqqnatlsdIIADLSTRQg------NTYLQLVTPNHSMVLAKKhiwgg 1385 unicellular c...
WP_045984862 2315 eaeqslaFTQALDQLQTDsangqgrllv----gegkqsltqVIHRLGQNSg------DSFYQLNTGNHALVLAKKtia-- 2382 Vibrio corall...
PAK92420     1689 -srhavaLRALIRDAQGAalqpgsm----------saasliHVDALADFLant--arSSHFVFSGTQHSMACGVNvldn- 1754 Stenotrophomo...
KQN54199      402 gkaaaepLVDILKSLRNNnsrsi-------------rtlseVMHDLVSATg------DISLSLHTGNHALALARKtvn-- 460  Serratia sp. ...
WP_129373382  946 edvesvgFQSLIRRLSAFgnsgdaaqsvl--ngqgnltldqVMSRLQAASg------DAFYELHTGNHAFAVAKKvsg-- 1015 Leisingera sp...
OEY99691     1573 -gaqagvVRALIRDAQGValqpgsv----------sassliAIDEIADFLakv--asSSQFILSGAQHSMALAVKvfan- 1638 Stenotrophomo...
WP_020407856 2281 efaqntdFRLLIDELHQTggqnaltq-------rgqqtleaVFADLSASSg------NKYLVLNTSNHSLQLARKsvn-- 2345 Hahella gangh...
WP_125358309  436 -egigaeFLSYVRDAQGVallpgat----------saqtkiAFDEFAQFLkgv--qgNAQFLLTGTVHSMVLAVEeqat- 501  Stenotrophomo...
Feature 1                       #                                                                 
6HV6_A        301 ------nkiKYVFYDPNYGMAYFDKh-------SDMAAFFQKKMQQYdf-------------------------pdDSVS 342  Photorhabdus ...
WP_136403027  828 --------dTYTFYDSNIGFVSFESl-------EKTGLFIQQHLDLItglgd--------------------yyelTHND 872  Flavobacteriu...
WP_139824363 1386 ipgrgrpeeSYFFYDPNFGEVEVSVenpdvdvaAALKQKIEAHLDQTssqgnwt---------------gklgtdlYGAN 1450 unicellular c...
WP_045984862 2383 ------gkaSYFFYDPNFADVVVTSqnsv-nsaDALGKIVKAHLQQAgdgwqgtla-----------dyyaadkagNGEL 2444 Vibrio corall...
PAK92420     1755 ------grrEYLLYDPNFGLMVFKKl-------SRFNQWVNNLFGSRyfsrlssrtlgdasaetlaemygaiptpgSQRM 1821 Stenotrophomo...
KQN54199      461 ------gevQYRLYDPNLGEITLPAggnaatteSSLVSLFNQLMEMNvgtgretla------------dfyqtvtrNGEY 522  Serratia sp. ...
WP_129373382 1016 ------gtaSYHFYETNAAEVKLSSssea-gtaGALKSVIESHLAQKssgghwegsl---------asyydtkknsSGSL 1079 Leisingera sp...
OEY99691     1639 ------ghrEYQLLDPNFGLMVFTKr-------SKLNAWLGSLFGSRyfsrlsggatgskadatlaemygavpapgSGRL 1705 Stenotrophomo...
WP_020407856 2346 ------gtdRFFFYDPNIGRLEAATa-------EGLRSTVQAVLDQAggslgqs----------------laeyyeLDTA 2396 Hahella gangh...
WP_125358309  502 ------garFYTHYCPTLGMTRFSSa-------SRFNAWMHRLFTSRyfsslqwaadgrwa-etlaemygatrateNAPP 567  Stenotrophomo...
Feature 1                 
6HV6_A        343 FHPLDYSN 350  Photorhabdus asymbiotica subsp. asymbiotica ATCC 43949
WP_136403027  873 VYITSYQN 880  Flavobacterium sp. CC-CTC003
WP_139824363 1451 VFDTYELN 1458 unicellular cyanobacterium SU2
WP_045984862 2445 QFELYRFE 2452 Vibrio coralliilyticus
PAK92420     1822 QFHLRQIH 1829 Stenotrophomonas rhizophila
KQN54199      523 TFTVSAPS 530  Serratia sp. Leaf51
WP_129373382 1080 VFDTYQFD 1087 Leisingera sp. NJS204
OEY99691     1706 QFHLRQVD 1713 Stenotrophomonas sp. BIIR7
WP_020407856 2397 GFNVSEFH 2404 Hahella ganghwensis
WP_125358309  568 TLFMIRQV 575  Stenotrophomonas sp. 278

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