Conserved Protein Domain Family
C58_RtxA
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cd20494: C58_RtxA 
peptidase C58-like domain of cytotoxin RtxA and similar proteins
This subfamily includes the C58 peptidase-like domain of Vibrio vulnificus biotype 3 multifunctional autoprocessing RTX (MARTX) toxin, the primary virulence factor of V. vulnificus. MARTX has been shown to be an essential virulence factor contributing to highly inflammatory skin wounds with severe damage affecting every tissue layer. This toxin is a large single-polypeptide composed of repeat sequences that form a pore in eukaryotic cell plasma membranes for the translocation of centrally located effector domains. This C58 family cysteine protease domain usually contains the invariant C/H/D residues that form an active site triad, however, cysteine is not fully conserved in this group.
Links
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Statistics
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PSSM-Id: 410775
Aligned: 37 rows
Threshold Bit Score: 100.924
Created: 18-Jun-2019
Updated: 25-Oct-2021
Structure
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Aligned Rows:
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catalytic site
Feature 1: catalytic site [active site], 3 residue positions
Conserved feature residue pattern:C H [DE]Click to see conserved feature residue pattern help
Evidence:
Scroll to Sequence Alignment Display
Sequence Alignment
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Format: Row Display: Color Bits: Type Selection: 
Feature 1                                                                                         
PQQ39489     1493 ELKKLIPEISNvlvtngnd-----------------------------------------------------------vq 1513 Photorhabdus ...
WP_049634943  135 DLNSVVRFLKSseynkslvdvya----------------------------------------------------faqei 162  Yersinia aldovae
WP_048616175  135 DFGNLPRSIRNdtdnetrinvfs----------------------------------------------------faqev 162  Yersinia alek...
WP_004702949  134 DLKGVISVLKNnkkinaivdvya----------------------------------------------------ftqei 161  Yersinia aldovae
WP_052489940   17 VTEFIQDVQNNsv------------------------------------------------------------------- 29   Yersinia aldovae
WP_006813565  150 LINYMSKSIDKnkvayk--------------------------------------------------------------- 166  Providencia r...
WP_123382105   50 TNEFLIYEINNkgadyiqqlnylydiinfdseglsaidkvkydalkmhaqvllndyiygfikiqgihnnslrnktyfdsl 129  Providencia a...
WP_132494502  131 NFKDYIDYVINtty------------------------------------------------------------------ 144  Providencia a...
WP_108478900  155 FLEYMSHSIDEgiesyk--------------------------------------------------------------- 171  Providencia a...
CFR02935      154 SLYALIQEIKEks------------------------------------------------------------------- 166  Yersinia fred...

Feature 1                 #                                                                       
PQQ39489     1514 skefleGICFALSSRYMMEERvn------------gvGGGKAYIEWlq---------------dvVKAYNDNSVNKKtdi 1566 Photorhabdus ...
WP_049634943  163 neksvaGRISNHDIIDTIEKYid------------nkDNNFKNILNeareng-------nnkkylIGYISDNLVENY--- 220  Yersinia aldovae
WP_048616175  163 keksvsGRISNNNLMNIIEKYlsgknnnvkesinnarKNGKNKSYF-------------------IDSIVNKLVEAH--- 220  Yersinia alek...
WP_004702949  162 hersiaGKISNNDLIDVIGKYiv------------sdDNDFKKSISnsrekg-------knkiylISAIIDNLAKQHmng 222  Yersinia aldovae
WP_052489940   30 -----tGKISNGDLINIIEKHl--------------gSDRDKIKRNldvared-----gntqlylINNIIENLIIEY--- 82   Yersinia aldovae
WP_006813565  167 -iyyrkNQIAKKYVDYMYELQri-------------kINDFYSALSkdsvffesgkgaellsdpwFISFYKKFNNRD--- 229  Providencia r...
WP_123382105  130 aydeinNRDFRDYLNDIIDKNfnkavn-----enkkdKVYYQYLYEsqkik----------lkeyINALYVGEDFFNtke 194  Providencia a...
WP_132494502  145 ----edSQFKGEYYESIVELQkik-----------tqKYYFALIADddffk----------skegLEISKDPFFMKLksh 199  Providencia a...
WP_108478900  172 -kyrekNKNKQQYADNLKELQkikl---------hqfYDALEIEFSq------------------IEKRNNPLAQDPwfk 223  Providencia a...
CFR02935      167 ----vgGRISHNDLIDVIEKYvacn--------degfKSTLNKIREkgkd-----------kkylISYILDDLVEHH--- 220  Yersinia fred...

Feature 1                                                                                         
PQQ39489     1567 n-----------------sieSSLLNRYRRQKvg----------paIEELLSIQHFqqldagsliekakgnidYSARLKA 1619 Photorhabdus ...
WP_049634943  221 ---------------------NKMKRDHVKDGsvtldkk-dispdmFGEMLGAAIEsertr--------sannYGGYLLE 270  Yersinia aldovae
WP_048616175  221 ---------------------NDKNSVYNSKGqriempseevkstaFGEILKVAIDnesir--------anseYAGILLS 271  Yersinia alek...
WP_004702949  223 ------------------nsvKEENGQYLASKvdkv------tsniFGEMLGVAINsekvr--------snnvYGGYLQD 270  Yersinia aldovae
WP_052489940   83 ---------------------NLLRNKESLSSvlni------dsvsFATMLRNAIDsekir--------asdnYSALLLD 127  Yersinia aldovae
WP_006813565  230 ---------------------NLQNNDFTLDDan-----------fFREMISKSIQwdn-----------yhqQEKFNSN 266  Providencia r...
WP_123382105  195 geiissdpiflklkdrfirggEVLGNKYSVSDan-----------fFIDSISESVNrdn-----------ylkLELINKK 252  Providencia a...
WP_132494502  200 f----------------sdinSPIDKHFTKHDakif------lkviFNDIQRDNYNk----------------VESFNML 241  Providencia a...
WP_108478900  224 qfhe-----------rfssrkNEIAKNFDINDan-----------fSKEMILKSLDfdn-----------ykiQKENNRK 270  Providencia a...
CFR02935      221 ---------------------SKINRVYSEDGqhvmmpkdkvksdlFGTMLGAAIEsekrr--------aadmYGGLLLE 271  Yersinia fred...

Feature 1                                                                 #                    #  
PQQ39489     1620 NGLTGARigdpln-----------yevdgYESVMEQLRNv----KQSTYMMFMSEDHAMSVVVHKSEVQt--IWSFFDPN 1682 Photorhabdus ...
WP_049634943  271 RGLIRSDprdektrrvet-knnriarndkFNNIINRLSNv----SHNKYISIMSPNHAMAISIIQGSNT---RWTFFDPR 342  Yersinia aldovae
WP_048616175  272 DGLIISDpdrsvdnrhikmkedfsssyekLNLLIDGLSDv----KNNSYISIMSPNHAMAISITLDENNk-kHWTFFDPN 346  Yersinia alek...
WP_004702949  271 RGLLIVGygdaetrrtrm-kndyfegsrkLNLLINDLADv----KKNSYITISSPNHAMAISVIIDSNNn-tHWTFFDPN 344  Yersinia aldovae
WP_052489940  128 RGLYSAIdsdekekydem-msgierenkkYKELMNDLVSv----ENDMYIAFDSPNHAMAISIIKDENSt--YWTFFDPN 200  Yersinia aldovae
WP_006813565  267 NGVKINDyyhsyldr------tsarteitVNKFIDKINNhiktsREQLLFEFSSPNHAMAISVKYNTDTkswDYLFFDPN 340  Providencia r...
WP_123382105  253 RGVQRNNihqnysf--------ntlkgttVKRFKDVVIGhtaknKTPLYYQLILGNHVVVVSAKYNNKNkswEYKFFDPN 324  Providencia a...
WP_132494502  242 RGMKREKshkgskyd------dhlkkeisLNEFIMKLNNetshgHDPLRYKFCSSIHVMAITADFNTETkswNFTFFDPN 315  Providencia a...
WP_108478900  271 NGVSLDLdnhsyngr------esyrseinLNEFIRKISShtkkgQETLLFEFKAVNHSMALVVEYNQKTqswGYNFFDPN 344  Providencia a...
CFR02935      272 RGLIRSGdrsedtrrtem-knnliessrkLKLLLNDISNi----SHNTYISISSPNHTLAISIVKNEKNk-iSWTFFDPN 345  Yersinia fred...

Feature 1                                                                             
PQQ39489     1683 FGAKSFDNYDDFHRFMDSFHkg-------------lITGYRSPigykyasaspedsakssFYINYNTF 1737 Photorhabdus luminescens
WP_049634943  343 YGGRVYDNYEDFKQGVYEHLrkieivk---gskrvvGIAYDLPedgl---------knmdFSINYIEY 398  Yersinia aldovae
WP_048616175  347 IGAKTYDNHADFRQGIYDIFnkhvg-------itklGAAYGFDkklf---------enmdFQVEYIKF 398  Yersinia aleksiciae
WP_004702949  345 FGAKQYNSHADFEQGVFDFLrmpntipnsktkgipiGVLYGFSeekl---------knmeISVGYSLF 403  Yersinia aldovae
WP_052489940  201 SGGKTFSNYKNFKSHVDGNMrl-------------kGVNYGFKinal---------inleFNIEYIKL 246  Yersinia aldovae
WP_006813565  341 IGIIKNHKKNDFSEFLHKYVsq-------------qSKFYLFKkkd------------ndFLINFTQF 383  Providencia rustigianii
WP_123382105  325 YGVAMINKQVDFFSYLDSHIkkiake----skipifENDYNIAvsefvkn---gnsgidfKKINNTSL 385  Providencia alcalifaciens
WP_132494502  316 TGIKKYENKEEFFGFLKNFVlk-------------qSDDYSFIalk-----------nndFKIGYYKY 359  Providencia alcalifaciens
WP_108478900  345 YGVFKYYDEASFKTFIIDFVdk-------------qADYYGFLrke-----------ngdFGIGYSSF 388  Providencia alcalifaciens
CFR02935      346 FGAKTFDNHTDLKKHIHNHLnkkitrn---gseivvGKYYDFPvdal---------etldFSVAYIKY 401  Yersinia frederiksenii

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