Conserved Protein Domain Family
Tudor_TNRC18
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cd20469: Tudor_TNRC18 
Tudor domain found in trinucleotide repeat-containing gene 18 protein (TNRC18) and similar proteins
TNRC18, also called long CAG trinucleotide repeat-containing gene 79 protein (CAGL79), is a protein that in humans is encoded by the TNRC18 gene. Its biological function remains unclear. TNRC18 contains one Tudor domain. The Tudor domain binds to proteins with dimethylated arginine or lysine residues, and may also bind methylated histone tails to facilitate protein-protein interactions.
Links
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Statistics
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PSSM-Id: 410540
Aligned: 13 rows
Threshold Bit Score: 134.469
Created: 30-May-2019
Updated: 25-Oct-2021
Structure
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Aligned Rows:
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putative
Feature 1:putative peptide binding site [polypeptide binding site]
Evidence:
  • Comment:based on the structures of other Tudor domain superfamily members with bound methylated/dimethylated peptides
  • Comment:In general, the Tudor domain binds to proteins with dimethylated arginine or lysine residues, and may also bind methylated histone tails to facilitate protein-protein interactions.
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Sequence Alignment
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Format: Row Display: Color Bits: Type Selection: 
Feature 1                       #     # #                        # # #                  
O15417       2220 STRFLPQGTRIAAYWSQQYRCLYPGTVVRGlld---ledDGDLITVEFDDGDTGRIPLSHIRLLPPDYKI 2286 human
OCT61409     2016 SIRFLPEGTRIAAYWSQQYRCLYPGTVVQGspd---qkeDSDLITVEFDDGDTGRIPLSHIRLLPPDYKI 2082 African clawed frog
XP_012939835 2653 SLRYLKEGTRVCAFWSQQFSCLYPGTVAKTspn----phNTNSVNVEFDDGDSGRIPINHIRLLPPDFPI 2718 California sea hare
XP_023234431 2108 SHHHLIEGSRVCAFWSQQYRCLYPGTVTKSns-----vpSDDLIYVEFDDGDSGRIPLEDIRLLPPNYPI 2172 bark scorpion
CAH65335       52 SVRFLPEGTRIAAYWSQQYRCLYPGTVVRGtld---leeDGDLITVEFDDGDTGRIPLSHIRLLPPDYKI 118  chicken
XP_011680691 2550 STRYLPEGTRICAYWSQQYKYLYPGTVVKGspn---ptlDANFTTVEFDDGDSGRIPLDHIRMLPQDFPL 2616 purple sea urchin
AWP18609     2116 SVRYLPEGTRIAAYWSQQYRCLYPGTVVSGssd---ideNDDLITVEFDDGDTGRIPLSHIRLLPPDYKI 2182 turbot
XP_007904339 2218 SVRFLPEGTRIAAYWSQQYRCLYPGAVVTGspd---pdeDEDLITVEFDDGDTGRIPLSHIRLLPPDYKI 2284 elephant shark
XP_014341809 2258 AVRFLPEGTRIAAYWSQQYRCLYPGTVVRGssd---pddDDDLITVEFDDGDTGRIPLSHIRLLPPDYKI 2324 coelacanth
XP_002738509 2563 STHYLPEGTRVCAYWSQQYRCLYPGCVSKGspn---pdiDDKLINVEFDDGDSGRIPLDHIRLLSQDYPI 2629 Saccoglossus kowalevskii
XP_013393047 1899 SPRYLPEGARVCAYWSQQFSCLYPGTVSKGspnp-ytssSKHLINVEFDDGDSGKIPIDHIRLLTPDYPI 1967 Lingula anatina
XP_002595515 2405 SVRFLPEGTRVSAYWSQQYRCLYPGTVARMspspdggedDKTFVSVEFDDGDSGRIPMDHVRLLPPNYPV 2474 Florida lancelet
RXG72632     1359 STRFLTEGTRVCAFWSQQYRGLYPGCVAAAsspt--hegNHNLVNVEFDDGDSGRIHVDDIRLLPQNFPI 1426 common pillbug

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