2QQS,2GFA,5VAR,2QQR,5D6W,2GF7


Conserved Protein Domain Family
Tudor_JMJD2A_rpt1

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cd20463: Tudor_JMJD2A_rpt1 
first Tudor domain found in Jumonji domain-containing protein 2A (JMJD2A) and similar proteins
JMJD2A, also called lysine-specific demethylase 4A (KDM4A), or JmjC domain-containing histone demethylation protein 3A (JHDM3A), catalyzes the demethylation of di- and trimethylated H3K9 and H3K36. It is involved in carcinogenesis and functions as a transcription regulator that may either stimulate or repress gene transcription. It associates with nuclear receptor corepressor complex or histone deacetylases. Moreover, JMJD2A forms complexes with both the androgen and estrogen receptor (ER), and plays an essential role in growth of both ER-positive and -negative breast tumors. It is also involved in prostate, colon, and lung cancer progression. JMJD2A contains jmjN and jmjC domains in the N-terminal region, followed by a canonical plant homeodomain (PHD) domain, a noncanonical extended PHD domain, and tandem Tudor domains. The model corresponds to the first Tudor domain. The Tudor domain binds to proteins with dimethylated arginine or lysine residues, and may also bind methylated histone tails to facilitate protein-protein interactions.
Statistics
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PSSM-Id: 410534
Aligned: 12 rows
Threshold Bit Score: 113.834
Created: 11-Dec-2018
Updated: 25-Oct-2021
Structure
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Program:
Drawing:
Aligned Rows:
 
peptide binding
Conserved site includes 7 residues -Click on image for an interactive view with Cn3D
Feature 1:peptide binding site [polypeptide binding site]
Evidence:
  • Structure:2QQS; Homo sapiens JMJD2A in complex with Histone H4K20me3 peptide, contacts at 4A
    View structure with Cn3D
  • Structure:5VAR; Homo sapiens JMJD2A in complex with a tri-methyl lysine competitive inhibitor, contacts at 4A
    View structure with Cn3D

Sequence Alignment
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Format: Row Display: Color Bits: Type Selection:
Feature 1                                         ## #### #              
2QQS_A          6 ITAGQKVISKHKNGRFYQCEVVRLtTETFYEVNFDDGSFSDNLYPEDIVSQDCLQ 60   human
2GFA_A          7 ITAGQKVISKHKNGRFYQCEVVRLtTETFYEVNFDDGSFSDNLYPEDIVSQDCLQ 61   human
5VAR_A          7 ITAGQKVISKHKNGRFYQCEVVRLtTETFYEVNFDDGSFSDNLYPEDIVSQDCLQ 61   human
2QQR_A          6 ITAGQKVISKHKNGRFYQCEVVRLtTETFYEVNFDDGSFSDNLYPEDIVSQDCLQ 60   human
5D6W_A          9 ITAGQKVISKHKNGRFYQCEVVRLtTETFYEVNFDDGSFSDNLYPEDIVSQDCLQ 63   human
2GF7_A          7 ITAGQKVISKHKNGRFYQCEVVRLtTETFYEVNFDDGSFSDNLYPEDIVSQDCLQ 61   human
CAF92847     1058 LVVGQKVICKHKNGRYYQCDVVQLsKETFYEVNFDDGSFSDNLFPEDIVSRDCAQ 1112 Tetraodon nigroviridis
NP_001107498  841 IVIGQAVISKHKNGRYYQCEVVKLtKETFYEVNFDDGSFSDNLYPEDIVSRDCLN 895  western clawed frog
O75164        899 ITAGQKVISKHKNGRFYQCEVVRLtTETFYEVNFDDGSFSDNLYPEDIVSQDCLQ 953  human
ETE65174      800 LAVGQPVISKHKNGRFYQCEVVNLtKETFYEVNFDDGSFSDNLYPEDIVSRDCLQ 854  king cobra
XP_007885249  873 IVIGQKVISKHKNGRFYQCEVVGLsKETFYEVNFDDGSFSDNLYPEDIVGRNCLQ 927  elephant shark
XP_014342855  845 IMVGQTVISKHKNSRYYQCEVVGMtKETFYEVNFDDGSFSDNLYPEDIVSQDCVK 899  coelacanth

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