Conserved Protein Domain Family

cd20456: Tudor_UHRF2_rpt1 
first Tudor domain found in ubiquitin-like PHD and RING finger domain-containing protein 2 (UHRF2) and similar proteins
UHRF2, also called Np95/ICBP90-like RING finger protein (NIRF), Np95-like RING finger protein, nuclear protein 97, nuclear zinc finger protein Np97, RING finger protein 107, or E3 ubiquitin-protein ligase UHRF2, was originally identified as a ubiquitin ligase acting as a small ubiquitin-like modifier (SUMO) E3 ligase that enhances zinc finger protein 131 (ZNF131) SUMOylation but does not enhance ZNF131 ubiquitination. It also ubiquitinates PCNP, a PEST-containing nuclear protein. UHRF2 also functions as a nuclear protein involved in cell-cycle regulation and has been implicated in tumorigenesis. It interacts with cyclins, CDKs, p53, pRB, PCNA, HDAC1, DNMTs, G9a, methylated histone H3 lysine 9, and methylated DNA. It interacts with the cyclin E-CDK2 complex, ubiquitinates cyclins D1 and E1, induces G1 arrest, and is involved in the G1/S transition regulation. Furthermore, UHRF2 is a direct transcriptional target of the transcription factor E2F-1 in the induction of apoptosis. It recruits HDAC1 and binds to methyl-CpG. UHRF2 also participates in the maturation of Hepatitis B virus (HBV) through interacting with HBV core protein and promoting its degradation. UHRF2 contains an N-terminal ubiquitin-like domain (UBL), a tandem Tudor domain (TTD), a plant homeodomain (PHD) domain, a SET- and RING-associated (SRA) domain, and a C-terminal RING finger domain. The model corresponds to the first Tudor domain. The tandem Tudor domain directs binding of UHRF to the heterochromatin mark histone H3K9me3.
PSSM-Id: 410527
Aligned: 6 rows
Threshold Bit Score: 160.779
Created: 11-Dec-2018
Updated: 25-Oct-2021
Aligned Rows:
Conserved site includes 8 residues -Click on image for an interactive view with Cn3D
Feature 1:putative peptide binding site [polypeptide binding site]
  • Comment:Based the structure evidence that Homo sapiens UHRF1 (4GY5) binds Histone H3k9me3.

Sequence Alignment
Format: Row Display: Color Bits: Type Selection:
Feature 1                                  #  #   #                                              
4TVR_A         4 PSTSARARLIDPGfGIYKVNELVDARDVgLGAWFEAHIHSVTRASdgqsrgktplkngn--------------------- 62  human
NP_001091384 110 PSTSARAFLIDPGiGIYKINELVDARDVsIGSWFEAHVENVTQNKkaqkngkaylkgghcyr------------------ 171 African clawed ...
Q96PU4       111 PSTSARARLIDPGfGIYKVNELVDARDVgLGAWFEAHIHSVTRASdgqsrgktplkngssckr----------------- 173 human
KFR11853      65 PSTSSHSFLIDPGlGLYKINELVDARDVsIGAWFEAHIENVTRGNtckrtngnlsqd----------------------- 121 Opisthocomus ho...
XP_014348024 109 PSTSARSFLIDPGiGLYKINELVDARDVsIGAWFEARIENVTRATkghnskalakggsankrt----------------- 171 coelacanth
XP_020325652 138 PSTSTRPFLIDAGiGVFKINELVDCRDIsIGAWFEACIDKVARTPkgqnsnskaptagkvgrpskrtngkleaepgqgqs 217 coho salmon
Feature 1                                                         # ## ##                  
4TVR_A        63 --------------ikhkskentnkldsVPSTSNSDCvaaDEDVIYHIQYDEYPESGTLEMNvkDLRPRARTIL 122 human
NP_001091384 172 ------------vangnlehsrenvvdtNPSTSYNDIlddNENVIYHIKYDDYPENGLVEMDlsNLRPRARTLL 233 African clawed frog
Q96PU4       174 ----------tngnikhkskentnkldsVPSTSNSDCvaaDEDVIYHIQYDEYPESGTLEMNvkDLRPRARTIL 237 human
KFR11853     122 -----------------hsrenannldsTPSTSYSDCmdtDEEAIYHIKYDEYPENGVVEMDtsNLRPRARTIL 178 Opisthocomus hoazin
XP_014348024 172 ----------ngnfsqlhssatsnnlgnTPSTSNSDCmdsDGDAIYHIKYDDYPENGVVEMLtgDVRPRARTIL 235 coelacanth
XP_020325652 218 hpssstdnsngnnysmlnsdsgpgaassTSQTDSTATdkeKEDVTYHIKYDDYPENGVVEMCggNVRPRARTLL 291 coho salmon

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