4HCZ,2E5P,2M0O,5XFQ,5XFN,5XFP


Conserved Protein Domain Family
Tudor_PHF1

?
cd20449: Tudor_PHF1 
Tudor domain found in PHD finger protein1 (PHF1) and similar proteins
PHF1, also called Polycomb-like protein 1 (PCL1), together with JARID2 and AEBP2, associates with the Polycomb repressive complex 2 (PRC2), which is the major H3K27 methyltransferase that regulates pluripotency, differentiation, and tumorigenesis, through catalysis of histone H3 lysine 27 trimethylation (H3K27me3) on chromatin. PHF1 is essential in epigenetic regulation and genome maintenance. It acts as a dual reader of lysine trimethylation at lysine 36 of histone H3 and lysine 27 of histone variant H3t. Moreover, PHF1 is required for efficient H3-K27 trimethylation (H3K27me3) and Hox gene silencing. It can mediate deposition of the repressive H3K27me3 mark and acts as a cofactor in early DNA-damage response. PHF1 consists of an N-terminal Tudor domain followed by two PHD domains, and a C-terminal MTF2 domain. Its Tudor domain selectively binds to histone H3K36me3.
Statistics
?
PSSM-Id: 410520
Aligned: 12 rows
Threshold Bit Score: 99.8984
Created: 11-Dec-2018
Updated: 25-Oct-2021
Structure
?
Program:
Drawing:
Aligned Rows:
 
peptide binding
Conserved site includes 11 residues -Click on image for an interactive view with Cn3D
Feature 1:peptide binding site [polypeptide binding site]
Evidence:

Sequence Alignment
?
Format: Row Display: Color Bits: Type Selection:
Feature 1                #  #   ###                 ##### #            
4HCZ_A         3 RLWEGQDVLARWTDGLLYLGTIKKVDsarEVCLVQFEDDSQFLVLWKDISPAAL 56  human
2E5P_A         9 RLWEGQDVLARWTDGLLYLGTIKKVDsarEVCLVQFEDDSQFLVLWKDISPAAL 62  human
2M0O_A        26 RLWEGQDVLARWTDGLLYLGTIKKVDsarEVCLVQFEDDSQFLVLWKDISPAAL 79  human
5XFQ_A         6 RLWEGQDVLARWTDGLLYLGTIKKVDsarEVCLVQFEDDSQFLVLWKDISPAAL 59  house mouse
5XFN_A         6 RLWEGQDVLARWTDGLLYLGTIKKVDsarEVCLVQFEDDSQFLVLWKDISPAAL 59  human
5XFP_A         6 RLWEGQDVLARWTDGLLYLGTIKKVDsarEVCLVQFEDDSQFLVLWKDISPAAL 59  human
O43189        30 RLWEGQDVLARWTDGLLYLGTIKKVDsarEVCLVQFEDDSQFLVLWKDISPAAL 83  human
EMP26576      40 RFWEGQDVLARWTDGLLYLGTIKKVDasrQVCLVQFEDNSQFLVLWKDINPAAV 93  Green sea turtle
AAH73196      35 RFWEGQDVLARWTDGLLYLGIVKKVDsaqETCLVRFEDNSQFSVLWKDIFPPAV 88  African clawed frog
XP_014346890  84 KFWENQDVLARWTDGLLYLGTIKKVDklkEMCLICFEDDSEFWVLWKDIHSSVV 137 coelacanth
XP_007883710  40 RLWEGQDVLARWSDGLLYLGNIRKVDaskRLNLVRFEDNSEFWVLNKDIHPPAV 93  elephant shark
KTG35713       3 GVSEGEDVLARWSDGLLYLGNVKRVDsikQCCLVRFEDNSEFWVLRKDIHSFSS 56  common carp

| Disclaimer | Privacy statement | Accessibility |
NCBI Home NCBI Search NCBI SiteMap