Conserved Protein Domain Family
Tudor_vreteno-like_rpt1
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cd20444: Tudor_vreteno-like_rpt1 
first Tudor domain found in Drosophila melanogaster protein vreteno and similar proteins
Vreteno is a gonad-specific protein essential for germline development to repress transposable elements and preventing their mobilization, which is essential for germline integrity. It acts via the piRNA metabolic process in both germline and somatic gonadal tissues by mediating the repression of transposable elements during meiosis. Vreteno contains two Tudor domains. The model corresponds to the first one. The Tudor domain binds to proteins with dimethylated arginine or lysine residues, and may also bind methylated histone tails to facilitate protein-protein interactions.
Links
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Statistics
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PSSM-Id: 410515
Aligned: 7 rows
Threshold Bit Score: 73.8781
Created: 11-Dec-2018
Updated: 25-Oct-2021
Structure
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Aligned Rows:
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putative
Feature 1:putative peptide binding site [polypeptide binding site]
Evidence:
  • Comment:based on the structures of other Tudor-like family proteins with bound methylated/dimethylated peptides
  • Comment:In general, the Tudor domain binds to proteins with dimethylated arginine or lysine residues, and may also bind methylated histone tails to facilitate protein-protein interactions.
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Sequence Alignment
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Format: Row Display: Color Bits: Type Selection: 
Feature 1                   #      #                    #  # #                  
Q9VCU7        371 PVCGQIVLYKF--EGHMSRAMVLNVdn----iKEIYVVFIDFGSVEVTq--lERLYECSSYL 424  fruit fly
KNC22885      466 PKCGQMVIAKF--ENQYNRALVLQAan----vEKILIIFVDYGNVEQMk--lEDLYEAPEEF 519  Australian sheep blowfly
OAD62691      825 PVIGEMVIAQYt-DKNYYRAIVTQVq-----dDKITVSYIDFGNIEVTd--iKKLKILSDNL 878  Eufriesea mexicana
XP_022833630  708 PQRGQLVIAQFt-DGNHYRAFVQRTna---kqNKFMIEYVEFGNVEVNk--lETLYQCPEDL 763  Spodoptera litura
B3M383        936 LTKGMMVLAKR--KGTFERAIIVRPetqnnrqPKFFVRFVDYGNTDLMy--iEQLRLMTKEL 993  Drosophila ananassae
XP_018016676 1673 ITPWMYCLVKSptDGVHYRAVVEDCtq---pdVGLLVRYLDYGNTELItdipNSVLECPDWL 1731 Hyalella azteca
XP_023320721  236 VSPGSLIIAPL--DGNLLRAKVKRIlg---peLDLVVEFLDFGNLDIVs--wWNCQNMYEYL 290  Eurytemora affinis

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