Conserved Protein Domain Family
Tudor_TDRD15_rpt2

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cd20437: Tudor_TDRD15_rpt2 
second Tudor domain found in Tudor domain-containing protein 15 (TDRD15) and similar proteins
TDRD15 is an uncharacterized Tudor domain-containing protein that contains seven Tudor domains. This model corresponds to the second one. The Tudor domain binds to proteins with dimethylated arginine or lysine residues, and may also bind methylated histone tails to facilitate protein-protein interactions.
Statistics
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PSSM-Id: 410508
Aligned: 7 rows
Threshold Bit Score: 189.551
Created: 3-Apr-2007
Updated: 25-Oct-2021
Structure
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Aligned Rows:
 
putative
Feature 1:putative peptide binding site [polypeptide binding site]
Evidence:
  • Comment:based on the structures of other Tudor-like family proteins with bound methylated/dimethylated peptides
  • Comment:In general, the Tudor domain binds to proteins with dimethylated arginine or lysine residues, and may also bind methylated histone tails to facilitate protein-protein interactions.

Sequence Alignment
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Format: Row Display: Color Bits: Type Selection:
Feature 1                                                                       #     #           
B5MCY1        239 VGSTESVKVSSALSPSKFYCQLikWTPELENLTAHMTLHYDTvcqet-sptcDNFGLLCVARRRNGQWHRGILQQLLPpN 317  human
XP_006000043  332 VGATKKVKITAAISFDKFYCQLlnQEQELKKMTKSITLCCESkikkg-ipmcENFGVMCAAKQKDGQWHRGVLQQLLPnG 410  coelacanth
OCT81294      246 VGTTEKIKISAAVSYSRFYCHLlsWEEELSNLTTLMFSHYETiniqq-nsilDNFGVLCAAKRKDGLWHRGIVETFLCgN 324  African clawe...
XP_007895290  266 TGVVETVKITCASGPHRFYCQLkrLNPELVELTRDMYCFYESqenemsdepiENCGALCAAKGKDGRWHRGLVKRLLTrS 345  elephant shark
EMP26150      246 VGSVEKVKITVAISPSKFYCQMlkWQKGLEDLTTTMTLHYEAvsren-vpscDSFGALCAAKRQKGQWHRGVIQQLLSdD 324  Green sea turtle
NP_001182210  251 VGQEVEVVVAAAVNPGLFYCRLssMGKDLQEMSDKLALACESgsgcltndldENLGLLCAVKGKDEKWHRGFVECLPLnS 330  zebrafish
XP_011491304  244 CGTEAEVRVTAAFNMGLFYCRMvsSEADLSKMSSQIGASCDReqk-----sqQSLDELCAVKGKDEKWYRGFLLSAPIpS 318  Japanese medaka
Feature 1              #  # #                              
B5MCY1        318 QVKIWFMDYGSSEAIPSiYVKKLKQDFIlVPLFSFPCSLTC 358  human
XP_006000043  411 QVKVWFIDYGNSEAVSPhSIQKLEPNFVsVPIMSFLCALSC 451  coelacanth
OCT81294      325 KVQIWFIDIGCRETISSsFVQKLKPQFLtLPMMAIPCSLKC 365  African clawed frog
XP_007895290  346 QVEVWFIDYGNYDLVYPhYIRKLIPDFFiMPLMSFACALTD 386  elephant shark
EMP26150      325 QVKVWFMDFGNSEAVPSnHVLKLQPVFTsLPMISFQCALSC 365  Green sea turtle
NP_001182210  331 QVKVVFVDSGYCESVKVeNILQLPSEFLsRPIMAFPCSLSC 371  zebrafish
XP_011491304  319 HLKVFFIDCGYFETVRAdSVHKLPALGFnSAPLAFPCRLAA 359  Japanese medaka

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