Conserved Protein Domain Family
Tudor_TDRD15_rpt1

?
cd20436: Tudor_TDRD15_rpt1 
first Tudor domain found in Tudor domain-containing protein 15 (TDRD15) and similar proteins
TDRD15 is an uncharacterized Tudor domain-containing protein that contains seven Tudor domains. This model corresponds to the first one. The Tudor domain binds to proteins with dimethylated arginine or lysine residues, and may also bind methylated histone tails to facilitate protein-protein interactions.
Statistics
?
PSSM-Id: 410507
Aligned: 8 rows
Threshold Bit Score: 196.102
Created: 28-Jan-2019
Updated: 25-Oct-2021
Structure
?
Aligned Rows:
 
putative
Feature 1:putative peptide binding site [polypeptide binding site]
Evidence:
  • Comment:based on the structures of other Tudor-like family proteins with bound methylated/dimethylated peptides
  • Comment:In general, the Tudor domain binds to proteins with dimethylated arginine or lysine residues, and may also bind methylated histone tails to facilitate protein-protein interactions.

Sequence Alignment
?
Format: Row Display: Color Bits: Type Selection:
Feature 1                                                                        #               #
B5MCY1         14 DLTISHIKCLPKDILVKFQGiksneCEFDYHVLQREIQHTPKVKn-------nVEIDEFCLVEERv---------sGEWQ 77   human
XP_007895290   38 NLKVTCVECHPEKTLVRFWGhdnslCELDYHILQNEIQNATKTKa-------sFGTDELCFAEDVy---------nGGWY 101  elephant shark
NP_001182210   20 ELKLTHIDCRPENKLVHFQGqymtiCELDYNILQVEIQNAVKSKv-------sVQVGDVCLVEDSg---------sGRWY 83   zebrafish
XP_006000043  100 DLKILHVECHSQEALIKFWGqytsvCELDYHILQNEIQHVTKIRd-------cIGTGEFCLVEETe---------lGEWH 163  coelacanth
XP_018121454   14 NLKIVAVACHPDNVIIKFQGkynsgNEFDYHVLQNEIQLVPKVQg-------dIGNWEFCLVQDKa---------fGVWQ 77   African clawe...
EMP26150       14 DLKVTHIECHPKEVLVTFQGkykteYDFDYHILQKEIQHISKVKd-------gIGIGEFCLVEDIn----------GEWH 76   Green sea turtle
KXJ72986      564 VRVDILRVVTPNEFYVSLVK-----NTSGIARMQEEIQNKMDEKmddgddktsWQQGEICLVFPTpskgrgneaigCEWY 638  Asian tiger m...
XP_551849     502 PDEFYVRVCSRKPCLERLHNt---iQQHMVEALDGNVAEEDDSGsge----cnWAVGDMCVVFTAtsd-----gdsSEWY 569  Anopheles gam...
Feature 1                           #  # #                                                        
B5MCY1         78 RGRVMEKk---NELYTVLLIDRGEELRVAgpQIASACGNLFeLPPRVVFGIFANILPVg--eKWSPKALNYFKSLVGIQV 152  human
XP_007895290  102 RGRLIRKi---DELYEVFLIDVGKVLKVDarHVALACMEFFqLPPKVLCGIFANVVPIg--gIWSSTAVNYFASLIASQL 176  elephant shark
NP_001182210   84 RGRVQNIe---KDKFHIFLLDHGDMMIVGpnCLSSISDTLLmLPPKIVCGFFANILPIq--sQWDSLTNSYFSSLKGSRI 158  zebrafish
XP_006000043  164 RGRVLNKs---SETYKVFLIDIGNVLTVSalHVASASGELFqLPPKIICGIFANVLPAt--eKWAPEAMKYFSSLTGLEV 238  coelacanth
XP_018121454   78 RGKVLNKi---NEKYEVFLIDHGNTVNVDstQIASASKELFsLGPRAVNGIFSGILPVk--eKWTPKAVNYFSSLVGLQV 152  African clawe...
EMP26150       77 RGRVLEKr---EEIYEVFLIDIGKVLIVNkiNVASACGELFqLPPKMVCGVFANILPVg--kKWGPKALNYFSSLIGLQI 151  Green sea turtle
KXJ72986      639 RARVLEVv--dDSNYTVFLIDKAYTMNSHysNMSTIPTELKeVHPAAIRCFLACIGPTgqqnVWSSSVVDAFKVAIEKFK 716  Asian tiger m...
XP_551849     570 RGRVTAVqeeaILQYQVFLIDRAESVRVHrtNMARLTSNVSqIQPGAVRCRLACIEPIggntSWHQTTLDTLINTIESYD 649  Anopheles gam...
Feature 1                 
B5MCY1        153 KGYVQAIL 160  human
XP_007895290  177 KGYVEDIL 184  elephant shark
NP_001182210  159 KGYIHARL 166  zebrafish
XP_006000043  239 KGHVQAIL 246  coelacanth
XP_018121454  153 EGHDQAVL 160  African clawed frog
EMP26150      152 KGHVQAIL 159  Green sea turtle
KXJ72986      717 CYSISLHG 724  Asian tiger mosquito
XP_551849     650 KHAISLDA 657  Anopheles gambiae str. PEST

| Disclaimer | Privacy statement | Accessibility |
NCBI Home NCBI Search NCBI SiteMap