Conserved Protein Domain Family
Tudor_TDRD12_rpt2

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cd20435: Tudor_TDRD12_rpt2 
second Tudor domain found in Tudor domain-containing protein 12 (TDRD12) and similar proteins
TDRD12, also called ES cell-associated transcript 8 protein (ECAT8), is a putative ATP-dependent DEAD-like RNA helicase that is essential for germ cell development and maintenance. It acts as a unique piRNA biogenesis factor essential for secondary PIWI interacting RNA (piRNA) biogenesis. TDRD12 contains two Tudor domains, one at the N-terminus and the other at the C-terminal end. The model corresponds to the second/C-terminal one. The Tudor domain binds to proteins with dimethylated arginine or lysine residues, and may also bind methylated histone tails to facilitate protein-protein interactions.
Statistics
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PSSM-Id: 410506
Aligned: 40 rows
Threshold Bit Score: 100.018
Created: 11-Dec-2018
Updated: 25-Oct-2021
Structure
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Aligned Rows:
 
putative
Feature 1:putative peptide binding site [polypeptide binding site]
Evidence:
  • Comment:based on the structures of other Tudor-like family proteins with bound methylated/dimethylated peptides
  • Comment:In general, the Tudor domain binds to proteins with dimethylated arginine or lysine residues, and may also bind methylated histone tails to facilitate protein-protein interactions.

Sequence Alignment
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Format: Row Display: Color Bits: Type Selection:
Feature 1                                                                              #     #    
Q587J7        892 NATNYFGRIVDKhmdl----------------yatLNAEMNEYFKDSNKttve----kvekFGLYGLAEKt--LFHRVQV 949  human
XP_026284994  951 SAGHFSVRLEELirpdkrte-------iwnsqytkIAFKMFNHFSKPENrklids-dkvavGDVYAMETIe-nLFHRVQV 1021 western flowe...
XP_024082240 1398 DATHFSVRILAHtsdmnitdisevhwdsfpssygvICLQMTQYFKNRENrrlhg---rpkvGDYVAIQKEadiLFLRGEV 1474 bed bug
OXU31874      768 HASHFSARIYEFirkneitgkne--nfsypfeafkLDIAMKKHYKEPQNrrgvk---diciGGFYTYRKPe-kDYARVQV 841  Trichomalopsi...
PSN55645      830 DASRFSARILEYsaedgeki-------kvsnnyfiTYMSVNKHYKDEANrkihg---vpklGDVCGFESKi-nVFQRVQV 898  German cockroach
XP_024215579 1422 NPSHYSVRVLATknsdsdeqw-----tefpsnyalIAFKMSNYFSFRENrfahg---rvkiGDLVAIEVEpdlMFKRAKV 1493 brown marmora...
EFX75071      406 TATQYYARILKHrneknqvi-------dmsgshfeVSAQLRNHFRDEAQrknsvdgnkveaGNIYAHRTTd-nLYERVRV 477  common water ...
RZF37551      878 SANHYSAQILEFkagsvwtkm------pnvellelISMKMDNYFSQQSNlftyp---npvlGDMVAVQPEn-dVFYRGKV 947  small brown p...
XP_018895856 1168 DASSYSARLLEVsedslmws-------hhsrnyavFATKLNMHYMDESNcyskd---kpevGDVVVYEHTp-gDFKRAKV 1236 Bemisia tabaci
XP_015910867  721 DATHYYVRLLKYispseenpkh----vsmsatyakIGFMLKKFYSMEENqikvn---svkiGEQYVLEDKn-kLFYRVKV 792  common house ...
Feature 1                            #  # #                                                
Q587J7        950 LEVNQKedaw-aldDILVEFIDEGRTGLVtr--------dQLLHLPEHFhtlppQAVEFIVCRVKPADNEIEW 1013 human
XP_026284994 1022 LEVLEKdknn-hpsVVQVKFLDEGEQKDIkv--------yCLYALPEELkvlpaEIVDVFLCGLLPADRDDGY 1085 western flower thrips
XP_024082240 1475 LEITARgprl-dpvEVLLVLIDEGLKTKMkv--------dELYELPTFLhepppQAVDVFLGNLRPVDLDNAW 1538 bed bug
OXU31874      842 QSIVEKdiktdkpkKVRVQSLDDGQIFPQvyyydflakvsELFELPQELlkykcTVVDIFLTGIAPFDHEYEW 914  Trichomalopsis sarco...
PSN55645      899 VELGKEdsag-kfdNVNVYFIDEGMYKEVqv--------hQLLALPKKLqemksHVLEVFLCNVKPCDLDTDW 962  German cockroach
XP_024215579 1494 IDIITRdeky-npeEIMVHFIDEGSVDKLtt--------sQLLHLPPELqvysqEAYDMYLIGLQPVDYDRSW 1557 brown marmorated sti...
EFX75071      478 ESILERdhqg-ipiEVTVISIDQGCVMSSfv--------kDLYEIPDDLknsapEAIEVFLVGAKPFDRNSNW 541  common water flea
RZF37551      948 ISILKRdekk-aprVVLVKLVDSGSIMEFnv--------mKLYDLPDELkayegQAIDVFLCNLKPADHDCSW 1011 small brown planthopper
XP_018895856 1237 IEEFRMtsqh-kpqEYRIKLIDEGLIISSkvl------gpNLLYCPTCFqedppYAITVYLCGLKPVDLDYSW 1302 Bemisia tabaci
XP_015910867  793 LNITESp------kEITFGFQDEGWVKTYtn--------cQLYYQVSDLdlpapVAAEVYLCGMTPPDSCLDW 851  common house spider

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