Conserved Protein Domain Family
Tudor_TDRD10
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cd20432: Tudor_TDRD10 
Tudor domain found in Tudor domain-containing protein 10 (TDRD10) and similar proteins
TDRD10 is widely expressed and localized both to the nucleus and cytoplasm, and may play general roles like regulation of RNA metabolism. It contains a Tudor domain and an RNA recognition motif (RRM). The Tudor domain binds to proteins with dimethylated arginine or lysine residues, and may also bind methylated histone tails to facilitate protein-protein interactions.
Links
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Statistics
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PSSM-Id: 410503
Aligned: 7 rows
Threshold Bit Score: 260.823
Created: 25-Jan-2019
Updated: 25-Oct-2021
Structure
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Aligned Rows:
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putative
Feature 1:putative peptide binding site [polypeptide binding site]
Evidence:
  • Comment:based on the structures of other Tudor-like family proteins with bound methylated/dimethylated peptides
  • Comment:In general, the Tudor domain binds to proteins with dimethylated arginine or lysine residues, and may also bind methylated histone tails to facilitate protein-protein interactions.
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Sequence Alignment
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Format: Row Display: Color Bits: Type Selection: 
Feature 1                                                                                        
Q5VZ19       175 LLRECFRDLSWLALIHSVRGEa-gLLVTSIVPKTPFFWAMHVTEaLHQNMQALFSTLAQAEEQQPYLegstVMRGTRCLA 253 human
EMP28221      29 MLKDCFKDLNWLVAIAKLHGEa-gLLVTDALPQTPYFWAIHLTEeSHSNMHKLFGRLAEEESKQPCLakqaVQRGTRCMA 107 Green sea turtle
XP_014344138 149 MLKDCFGDLSWLVLIMRPIGEeveLMVTETIPHAPYFWAILLTEqAQANMQQLFSSLTSINSKQPFLmkrdITRGRRCMA 228 coelacanth
XP_018087191 411 MLKDCFQKLSWLAAIMKVSGEv-dLLVTNVIPQTPYFWAVLLTKeICINMASLSRDLAEVEPRLPFLteeaVHRGRRCLA 489 African clawed ...
XP_007438981 162 VLNDCFGDARWLLSVANVVGDv-gLLVTDTFPLTPYFWAIVLGEeRLQTMQRLFSALAEAETQLPFLakqdVRRGIRCLA 240 Burmese python
XP_020367790 170 MLTSCFKDIGWMAESTKVHGDv-gLMVMDTFPHMPYFWAMNLTPeTYVKMCQLFNTLSVVTQEQPFLkeeeVQRGRRCMA 248 whale shark
XP_028647557  96 ILNECFGNLNWFGSIMKDEGEt-aVMVTETYPETPFFWAIQLSEvSQNKMVTLFTAIAKSEKNQPYLgkddAHRGKKCLA 174 reedfish

Feature 1         #          #               #  # #                           
Q5VZ19       254 EYhlgd-yghAWNRCWVLDRVdTWAVVMFIDFGQLATIPVqSLRSLDSDDFWTIPPLTQPF 313 human
EMP28221     108 ECtlgd-dgaAWNRCWVLEKVeDLAVVLFVDFGRSATVPLnSLRKLDEDDIWAIKPLAQPF 167 Green sea turtle
XP_014344138 229 ECmleeaeegTWNRCWIIDVVgDFAVVLFIDFGSTALIPLdSIKCLDEDEFWVIPPLAQPF 289 coelacanth
XP_018087191 490 QIppsngeeaVWNRAWVYDVIfDLAVVFMLDYGLTANVPVrSLRPLDDAHFWVTPPLAQPF 550 African clawed frog
XP_007438981 241 ECnige-egsAWNRCWVLDTLeNVAVVFFVDFGHCANIPLsSLRKLEGDEFWQIRPLAQPF 300 Burmese python
XP_020367790 249 EFpge---agEWNRCWIVDVVeSRVILFYVDSGSTACVPApSVKSLDKDEFWAIPPLIQPF 306 whale shark
XP_028647557 175 EFlftphdagAWNRACILEVVnFFALVFFVDFGSTAFIPIySLKFLSEEEFWQIPPLTQPF 235 reedfish

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