Conserved Protein Domain Family
Tudor_TDRD8

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cd20430: Tudor_TDRD8 
Tudor domain found in Tudor domain-containing protein 8 (TDRD8) and similar proteins
TDRD8, also called serine/threonine-protein kinase (EC 2.7.11.1) 31 (STK31), serine/threonine-protein kinase NYD-SPK, or Sugen kinase 396 (SgK396), is a germ cell-specific factor expressed in embryonic gonocytes of both sexes, and in postnatal spermatocytes and round spermatids in males. It acts as a cell-cycle regulated protein that contributes to the tumorigenicity of epithelial cancer cells. TDRD8 contains a Tudor domain and a serine/threonine kinase domain. The Tudor domain binds to proteins with dimethylated arginine or lysine residues, and may also bind methylated histone tails to facilitate protein-protein interactions.
Statistics
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PSSM-Id: 410501
Aligned: 14 rows
Threshold Bit Score: 113.926
Created: 24-Nov-2006
Updated: 25-Oct-2021
Structure
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Aligned Rows:
 
putative
Feature 1:putative peptide binding site [polypeptide binding site]
Evidence:
  • Comment:based on the structures of other Tudor-like family proteins with bound methylated/dimethylated peptides
  • Comment:In general, the Tudor domain binds to proteins with dimethylated arginine or lysine residues, and may also bind methylated histone tails to facilitate protein-protein interactions.

Sequence Alignment
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Format: Row Display: Color Bits: Type Selection:
Feature 1                                     #      #                #  # #                 
Q9BXU1         61 IGCSLSEVCPqassvlgnLDPNKIYGGLFSEDqCWYRCKVLKiisvEKCLVRYIDYGNTEILnrSDIVEIPLELQ 135  human
PVD39150      109 ITVRLAEVCPtacavqgsIDMNKIYGCKFSEDgLWYRCQVKSkhnsDKMKVQYIDFGNCEEVnpKDLVELPDDLT 183  Pomacea canaliculata
XP_007901362   45 TFTALTEICPfaakvfgdPVPEKIYGGLYSEDqCWYRCKLKKmlndEKCLMTYIDYGNSETLkkSYIVELPENLQ 119  elephant shark
XP_013407204  152 LLHMNINTCKsvq---gpPHFDRVYAAVFSEDdMLYRCKVLShhsmEKSLVQYIDYGNREVVsnSSIVELSPQWS 223  Lingula anatina
KFM81662      172 FSIAINNLCSklprlnrkPVIRQVYAAIYSEDkSWYRCIVQNvtsaGMCTICYIDYGNTEEVryLNLVELPDSLQ 246  Stegodyphus mimosarum
XP_002596189  159 FSEELQNVCPkglpltsaPKPRQLYGAKFAEDeQWYRCRVINmvsdDQALVQYVDYGNTETIqwREIHQLPLDFA 233  Florida lancelet
OCA31006       29 LSDSLAKTCPtmspvfgtPDHDKIYGGMFTADtCWYRCKLNSilsdDQCRATYIDYGNSEVLnrSSIVELPDDLQ 103  tropical clawed frog
ELT94759      164 LSDTLNAVCPkapvlsdqPNMTKIYGCKYSVDdSWYRCKVLRylniNESEVLYLDFGNQEEVmnSSICELPPALT 238  Capitella teleta
KPP65431       13 MTGILSQKCPtaqrlpgnPVPRKVYGALYSEDnCWYRCKVQQhn-gEKFQVLYIDYGNTELVsrSCLVELPEDLQ 86   Asian bonytongue
PFX26469      111 MSNDLQIYCRnkpllqstPHVGKIYGGVYLEDqQWYRCRVKElieeDKVKVHFVDFGNTEVIslRSIVFLSHDFL 185  Stylophora pistillata

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