Conserved Protein Domain Family
Tudor_TDRD6_rpt5

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cd20424: Tudor_TDRD6_rpt5 
fifth Tudor domain found in Tudor domain-containing protein 6 (TDRD6) and similar proteins
TDRD6, also called antigen NY-CO-45 or cancer/testis antigen 41.2 (CT41.2), is a testis-specific expressed protein that was localized to the chromatoid bodies in germ cells, and is involved in spermiogenesis, chromatoid body formation, and for proper precursor and mature miRNA expression. Mutations in TDRD6 may be associated with human male infertility and early embryonic lethality. TDRD6 contains seven Tudor domains. This model corresponds to the fifth one. The Tudor domain binds to proteins with dimethylated arginine or lysine residues, and may also bind methylated histone tails to facilitate protein-protein interactions.
Statistics
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PSSM-Id: 410495
Aligned: 4 rows
Threshold Bit Score: 234.321
Created: 27-Oct-2006
Updated: 25-Oct-2021
Structure
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Aligned Rows:
 
putative
Feature 1:putative peptide binding site [polypeptide binding site]
Evidence:
  • Comment:based on the structures of other Tudor-like family proteins with bound methylated/dimethylated peptides
  • Comment:In general, the Tudor domain binds to proteins with dimethylated arginine or lysine residues, and may also bind methylated histone tails to facilitate protein-protein interactions.

Sequence Alignment
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Format: Row Display: Color Bits: Type Selection:
Feature 1                                                                              #     #    
O60522        975 YFYSTHDMKIGSEELVYITHIddpwtFYCQLARNANILEQLSCSITQLSKVLlnlktsPLNPGTLCLAKYTDGNWYRGIV 1054 human
BAD51732      939 YYYSMHDIKIGGEEEVYITYVnssleFYCQLSRNTETIDMIASATARVCSEVrkf-elSVTPGPLCLAKFSDQQWYRCFI 1017 African clawe...
XP_014348589  972 YYYSTHDIKIGSEEQVYVTYVinpgtFYCQLARNSGVLDQLAGKISILSTKIqph-kcAVNPGTLCLAKYSDQHWYRGKV 1050 coelacanth
KFW94604      932 YYYSMHGIKIGNEEDVYITHVedpwtFYCQLERCAGVLAQLTNNISRLSETItsl-etSQKSGSLCLAKYTDNHWYRGII 1010 great cormorant
Feature 1                   #  # #                               
O60522       1055 IEk-ePKKVFFVDFGNIYVVTSdDLLPIPSDAydvllLPMQAVRCSL 1100 human
BAD51732     1018 NTnknSTDAFFVDYGNTEKVNKeEMLPIPSDAyellhFPMQAIKCSL 1064 African clawed frog
XP_014348589 1051 ISlksKIEVFFVDYGNTQIVEKeDLLPIPNEAqellfLPMQAIKCKL 1097 coelacanth
KFW94604     1011 IKrtpNTEVFFVDFGNTETVEKdHMLPLPSDAcdvllLPMQAIKCSL 1057 great cormorant

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