Conserved Protein Domain Family
Tudor_TDRD6_rpt4

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cd20423: Tudor_TDRD6_rpt4 
fourth Tudor domain found in Tudor domain-containing protein 6 (TDRD6) and similar proteins
TDRD6, also called antigen NY-CO-45 or cancer/testis antigen 41.2 (CT41.2), is a testis-specific expressed protein that was localized to the chromatoid bodies in germ cells, and is involved in spermiogenesis, chromatoid body formation, and for proper precursor and mature miRNA expression. Mutations in TDRD6 may be associated with human male infertility and early embryonic lethality. TDRD6 contains seven Tudor domains. This model corresponds to the fourth one. The Tudor domain binds to proteins with dimethylated arginine or lysine residues, and may also bind methylated histone tails to facilitate protein-protein interactions.
Statistics
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PSSM-Id: 410494
Aligned: 5 rows
Threshold Bit Score: 123.36
Created: 11-Dec-2018
Updated: 25-Oct-2021
Structure
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Aligned Rows:
 
putative
Feature 1:putative peptide binding site [polypeptide binding site]
Evidence:
  • Comment:based on the structures of other Tudor-like family proteins with bound methylated/dimethylated peptides
  • Comment:In general, the Tudor domain binds to proteins with dimethylated arginine or lysine residues, and may also bind methylated histone tails to facilitate protein-protein interactions.

Sequence Alignment
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Format: Row Display: Color Bits: Type Selection:
Feature 1                  #      #                   #  # #                                   
O60522     815 PHQRNTLACLAKRTvnrQWSRALISGIqs---vEHVNVTFVDYGDREMVSVk---NIYSISEEFLKVKaQAFRCSLYNLI 888  human
KFM61406   441 EDIKANMPCVAKCGe-gTWCRAIITEVd----vDNIYVTLVDYGTPELLAIk---NLRAINPELVEIPpVAVECSLFGVQ 512  Stegodyphus mimo...
KYO34112   542 PHYLPNPVCLAKYSedkKWYRALILSGil--pkEEVEVIYVDYGNKDVVSLk---NLCSINADFLKLKaQAFRCSLYNLI 616  American alligator
GCF52786   839 PHDWPNPVCLAKYSedgKWYRALIVRVar--ptEGVEVAYVDYGNKELVPLk---NLRSTRPEFLQLKaQAFRCSLYNLI 913  Paroedura picta
KFM76079   133 VESLVNRICVAKYSd-gHWCRVVLDNVyetsnpEMVKVLYVDYGHDGIVNRsdirKLEPISEFLAFLPyQCVECELFDAV 211  Stegodyphus mimo...
Feature 1           
O60522     889 QPVGQ 893  human
KFM61406   513 AIEGN 517  Stegodyphus mimosarum
KYO34112   617 QPTGP 621  American alligator
GCF52786   914 QPNSQ 918  Paroedura picta
KFM76079   212 PWSGA 216  Stegodyphus mimosarum

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