Conserved Protein Domain Family
Tudor_TDRD6_rpt2

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cd20421: Tudor_TDRD6_rpt2 
second Tudor domain found in Tudor domain-containing protein 6 (TDRD6) and similar proteins
TDRD6, also called antigen NY-CO-45 or cancer/testis antigen 41.2 (CT41.2), is a testis-specific expressed protein that was localized to the chromatoid bodies in germ cells, and is involved in spermiogenesis, chromatoid body formation, and for proper precursor and mature miRNA expression. Mutations in TDRD6 may be associated with human male infertility and early embryonic lethality. TDRD6 contains seven Tudor domains. This model corresponds to the second one. The Tudor domain binds to proteins with dimethylated arginine or lysine residues, and may also bind methylated histone tails to facilitate protein-protein interactions.
Statistics
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PSSM-Id: 410492
Aligned: 6 rows
Threshold Bit Score: 216.136
Created: 27-Oct-2006
Updated: 25-Oct-2021
Structure
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Aligned Rows:
 
putative
Feature 1:putative peptide binding site [polypeptide binding site]
Evidence:
  • Comment:based on the structures of other Tudor-like family proteins with bound methylated/dimethylated peptides
  • Comment:In general, the Tudor domain binds to proteins with dimethylated arginine or lysine residues, and may also bind methylated histone tails to facilitate protein-protein interactions.

Sequence Alignment
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Format: Row Display: Color Bits: Type Selection:
Feature 1                                                                                         
O60522        240 DYFYPQLQLGVTEAVVITQVc--hPHRIHCQLRSVSQEIHRLSESMAQVYRgstgtgdenstsatweereesPDKPGSPC 317  human
BAD51732      243 DYFYPQFQVGVIEPVLVTEVa--nPHRIFCQLRSLSHEVQRLSESMHHFYElqsgsg---------ernyiqPLIPGQPC 311  African clawe...
XP_694024     233 AYMFPELQTDTVETVVITEVt--sPFRIFCQLKVFSQELKKLTEQITQYYEgrvgs------------yfarAENLGSPC 298  zebrafish
XP_014348589  246 DYFYPLLQVGVIESVIVTHVi--dPHRVFCQLRSLSQEVKRLSEHMYQFYErrhgl------------detwPEKLGSPC 311  coelacanth
XP_007895293  324 NYFYPLLQVDETVTVTVRVThvryPDRFFCQLRCHCPELERLHLSMHRYYEssrvs-----------gtgtaPRKLGSPC 392  elephant shark
PKK33699      263 DYFYPQLQLGVTEPVLVTHVs--dPHHIYCQLQCLSQEIRCLSETMCHMYEqwe---------------qeyLPKVGSPC 325  rock pigeon
Feature 1            #     #                    #  # #                              
O60522        318 ASCGlDGHWYRALLLETFrp---qRCAQVLHVDYGRKELVSCsSLRYLLPEYFRMPVVTYPCALYG 380  human
BAD51732      312 ACRGsDGRWYRSLLQEYYpd---kKLAMVIHVDWGRRDVISInCLRALAADYFRMPVVTFPCSLFG 374  African clawed frog
XP_694024     299 ASRGsDGKWYRSVLQQVMsa---nNVVEVLHVDYGKKQFVQVeNVKPLASEFFRMPVVTYVCSLHG 361  zebrafish
XP_014348589  312 AAKGnDFRWHRAVVHQVFss---iHTVEVLYVDYGRKEFVPKsNIRYLIPEYFRMPVVTYSCALFG 374  coelacanth
XP_007895293  393 AAKSlDGRWYRAVVQQTLs----dRGVEVFLVDYGNKEVVSScSIRKLSPGYFKMPVVTYPFALRE 454  elephant shark
PKK33699      326 AARDiDGRWYRALLLELIageqdrQVALVIFVDYGRKETVTRaNLRHLPVECFRMPVVTYPCALQG 391  rock pigeon

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