Conserved Protein Domain Family
Tudor_TDRD6_rpt1

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cd20420: Tudor_TDRD6_rpt1 
first Tudor domain found in Tudor domain-containing protein 6 (TDRD6) and similar proteins
TDRD6, also called antigen NY-CO-45 or cancer/testis antigen 41.2 (CT41.2), is a testis-specific expressed protein that was localized to the chromatoid bodies in germ cells, and is involved in spermiogenesis, chromatoid body formation, and for proper precursor and mature miRNA expression. Mutations in TDRD6 may be associated with human male infertility and early embryonic lethality. TDRD6 contains seven Tudor domains. This model corresponds to the first one. The Tudor domain binds to proteins with dimethylated arginine or lysine residues, and may also bind methylated histone tails to facilitate protein-protein interactions.
Statistics
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PSSM-Id: 410491
Aligned: 6 rows
Threshold Bit Score: 196.88
Created: 30-Mar-2007
Updated: 25-Oct-2021
Structure
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Aligned Rows:
 
putative
Feature 1:putative peptide binding site [polypeptide binding site]
Evidence:
  • Comment:based on the structures of other Tudor-like family proteins with bound methylated/dimethylated peptides
  • Comment:In general, the Tudor domain binds to proteins with dimethylated arginine or lysine residues, and may also bind methylated histone tails to facilitate protein-protein interactions.

Sequence Alignment
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Format: Row Display: Color Bits: Type Selection:
Feature 1                                                                                         
O60522          6 GMPAPGASLALRVSFVdv-hPDVIPVQLWGlv-gERRGEYLRLSREIQeaaatrgq-----------walgsasaSPGEL 72   human
CAG13205      205 GLPAKGSVVSVLVARVn--lRGCGLVELWVhmddGRKHVYQQMTEDIQspgrmf----------------tgsegTSGDF 266  Tetraodon nig...
XP_014348589    6 GVPTPGALLNLRVSWVel-hPDLVLVRVWGfd-rQREGDYQRLQREIQtaaksrf-------------gsggrspSVGDL 70   coelacanth
XP_007895293    9 GLPPSGVRMPFQVTRVdparQGSVLVRLWGrfhrERQLEYQRLHDEIQnwvkgvgdggaggaaaaagrdpptpplETNER 88   elephant shark
KFQ99191        6 GMLSPGATVTLRVCAVgl-rPEVPVVRLWGll-gERSADYVCLRREIQatvgprlaaapg----pgglvaggaelCTGDL 79   crested ibis
BAD51732        6 VLPVPGTVLKLSVSFLdv-tAEVPFVRLWSsl-rERKEEYEGLKTEVQaavlaepcg----------agdkdwtpAVGHY 73   African clawe...
Feature 1             #    #               #  # #                                 
O60522         73 CLVQVgLLWHRCRVVSRQAQESRVFLLDEGRTITAGAgSLAPGRREFFNLPSEVLGCVLAGLVP 136  human
CAG13205      267 CLVCVgGIWHRARIVSVESENYKVFLIDQGQSHVTTGkSLAWGRRDSFSLPPEIEPCVLADVLI 330  Tetraodon nigroviridis
XP_014348589   71 CLVELnETWHRCRIVGRTGDDFQVFFLDRGCTLPADAlSLAQGRDSFFHLPPEVIGCFLANLVP 134  coelacanth
XP_007895293   89 CLAEMnGEWHRARVVSRAGDDYTVFTLDEGRATAVRGrGLERGKKDFFQLPPEAVCCILANLVP 152  elephant shark
KFQ99191       80 GLVEVvGLWYRCCVVSRRGQDYRVFLLDEGFTVVTSAcYLARGCKELFRLPPEVLGCIVADVMP 143  crested ibis
BAD51732       74 CVAEVdGRWHRCELLHRQGVEYSVFLIDVGYTVPARAhQLKEAPKSLFCLPGEVLGYVLSNLVP 137  African clawed frog

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