Conserved Protein Domain Family
Tudor_TDRD4_rpt4
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cd20417: Tudor_TDRD4_rpt4 
fourth Tudor domain found in Tudor domain-containing protein 4 (TDRD4) and similar proteins
TDRD4, also called RING finger protein 17 (RNF17), is a component of the mammalian germ cell nuage and is essential for spermiogenesis. It seems to be involved in the regulation of transcriptional activity of MYC. In vitro, TDRD4 inhibits the DNA-binding activity of Mad-MAX heterodimers. It can recruit Mad transcriptional repressors (MXD1, MXD3, MXD4 and MXI1) to the cytoplasm. TDRD4 also acts as a potential cancer/testis antigen in liver cancer. TDRD4 contains a RING finger and five Tudor domains. This model corresponds to the fourth one. The Tudor domain binds to proteins with dimethylated arginine or lysine residues, and may also bind methylated histone tails to facilitate protein-protein interactions.
Links
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Statistics
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PSSM-Id: 410488
Aligned: 6 rows
Threshold Bit Score: 129.092
Created: 27-Oct-2006
Updated: 25-Oct-2021
Structure
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Aligned Rows:
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putative
Feature 1:putative peptide binding site [polypeptide binding site]
Evidence:
  • Comment:based on the structures of other Tudor-like family proteins with bound methylated/dimethylated peptides
  • Comment:In general, the Tudor domain binds to proteins with dimethylated arginine or lysine residues, and may also bind methylated histone tails to facilitate protein-protein interactions.
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Sequence Alignment
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Format: Row Display: Color Bits: Type Selection: 
Feature 1                   #     #                #  # #                              
Q9BXT8       1229 WKKGEACAVRGsdtLWYRGKVMEVVG-GAVRVQYLDHGFTEKIPqCHLYPILLypdiPQFCIPCQLHNT 1296 human
AAH91894       50 WKGVLGCAVMGtdmFWYRGQVQEVIG-GHVKVRYVDQGLVESIPvCHVYPMVLcedvPQLCVPCQINGV 117  zebrafish
XP_014353440 1232 WKKGEACVVRGsdtIWYRGKVVEVIG-GSIRVQYIDQGYIEKIPqCHLYPSILfadkPQFCIPCELYRM 1299 coelacanth
XP_007903795 1209 YSKGEGCVVKGsdtLWYRGKILEVIG-VCVKVYYVDNGYIETIPhVHVYPMVMypeiPELCLPFQLYGV 1276 elephant shark
XP_018105829 1144 WKEGEGCLIKGsdaRPYRGKVLKILGgEMILVQYVDYGCIEKILlCHTSAIVFnpdvPLFCIPCQLHKT 1212 African clawed frog
TFK09942      876 WKKEEACVVRGsdtMWYRGKVIEVVG-GTVRVQYVDYGYIEKIPpCHLYPVALyadiPTFCIPCQLYKT 943  big-headed turtle

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