Conserved Protein Domain Family
Tudor_TDRD4_rpt1

?
cd20414: Tudor_TDRD4_rpt1 
first Tudor domain found in Tudor domain-containing protein 4 (TDRD4) and similar proteins
TDRD4, also called RING finger protein 17 (RNF17), is a component of the mammalian germ cell nuage and is essential for spermiogenesis. It seems to be involved in the regulation of transcriptional activity of MYC. In vitro, TDRD4 inhibits the DNA-binding activity of Mad-MAX heterodimers. It can recruit Mad transcriptional repressors (MXD1, MXD3, MXD4 and MXI1) to the cytoplasm. TDRD4 also acts as a potential cancer/testis antigen in liver cancer. TDRD4 contains a RING finger and five Tudor domains. This model corresponds to the first one. The Tudor domain binds to proteins with dimethylated arginine or lysine residues, and may also bind methylated histone tails to facilitate protein-protein interactions.
Statistics
?
PSSM-Id: 410485
Aligned: 6 rows
Threshold Bit Score: 76.093
Created: 11-Dec-2018
Updated: 25-Oct-2021
Structure
?
Aligned Rows:
 
putative
Feature 1:putative peptide binding site [polypeptide binding site]
Evidence:
  • Comment:based on the structures of other Tudor-like family proteins with bound methylated/dimethylated peptides
  • Comment:In general, the Tudor domain binds to proteins with dimethylated arginine or lysine residues, and may also bind methylated histone tails to facilitate protein-protein interactions.

Sequence Alignment
?
Format: Row Display: Color Bits: Type Selection:
Feature 1                  #      #                                   #  # #                    
Q9BXT8        465 ELGARIFVSSikNGMWCRGTITElipiegrntrkpcsptrlfvhevaLIQIFMVDFGNSEVLivtg-vvdTHVRPEHS 541  human
XP_014353440  462 ELGENIFAKSkeNGMWCRGTVSElipsdnknagkpngptkyavkdvaVMQVFMVDYGHSEVFivagfksvPVVRPEHV 539  coelacanth
XP_007903794  562 ELGERIIVKSnlFCTWCRGIITElvpseeneekpn-gptryritevaVMQVFLLDIGHSEIFvvtg-fnnLVKKLQDG 637  elephant shark
XP_018105829  407 VLGEIIAINStkHELWCRGEIIAliplenkykgkpcgptqykiedvlLLKVFLLDYGSTEVFssvryvgnKFSRTEDC 484  African clawed ...
EMP36445      166 QESARIFINSkeNGMWCRGTITEliplesknkekpcgstkykihdvaVMQVFMEDFGNSEVLvgsgiggvPVVRPEQV 243  Green sea turtle
KOX72910      173 AVDRLVAVKSdtRGKWCRGKIVSkva-------------------knVCKVRLMDYGDSEVAtln---dvLEIRDNFL 228  Melipona quadri...

| Disclaimer | Privacy statement | Accessibility |
NCBI Home NCBI Search NCBI SiteMap