6HQ9


Conserved Protein Domain Family
Tudor_ERCC6L2

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cd20400: Tudor_ERCC6L2 
Tudor domain found in DNA excision repair protein ERCC-6-like 2 (ERCC6L2) and similar proteins
ERCC6L2, also called DNA repair and recombination protein RAD26-like (RAD26L), may be involved in early DNA damage response. It regulates RNA Pol II-mediated transcription via its interaction with DNA-dependent protein kinase (DNA-PK) to resolve R loops and minimize transcription-associated genome instability. ERCC6L2 gene mutations have been associated with bone marrow failure that includes developmental delay and microcephaly. It contains an N-terminal Tudor domain. The Tudor domain binds to proteins with dimethylated arginine or lysine residues, and may also bind methylated histone tails to facilitate protein-protein interactions.
Statistics
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PSSM-Id: 410471
Aligned: 15 rows
Threshold Bit Score: 81.9881
Created: 30-Mar-2007
Updated: 25-Oct-2021
Structure
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Program:
Drawing:
Aligned Rows:
 
putative
Conserved site includes 6 residues -Click on image for an interactive view with Cn3D
Feature 1:putative peptide binding site [polypeptide binding site]
Evidence:
  • Comment:based on the structures of other Tudor domain superfamily members with bound methylated/dimethylated peptides
  • Comment:In general, the Tudor domain binds to proteins with dimethylated arginine or lysine residues, and may also bind methylated histone tails to facilitate protein-protein interactions.

Sequence Alignment
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Format: Row Display: Color Bits: Type Selection:
Feature 1                   #    # #                     #    # #             
6HQ9_A          6 WHPGERCLAPSPdNGKLCEASIKSItvde-ngkSFAVVLYA---DFQERKIPLkQLQEVK 61   human
XP_007898171   12 WYPGDQVLAPFSkDGKLYEATVKTIstde-hgkTVAIVKFS---SFNDETVLInTLRRRK 67   elephant shark
XP_020606615   38 WHKGHSCLAPYSgDNEYYEAIINSIhdts-nghREAVVTFIgyeSEGSEVVPVtALRKTT 96   Orbicella faveolata
XP_011663781    5 WSIGDKCMAPFSgDGSLYKAVIRKIeedg-dgrKMAEVHYKgflPEDNELVPLeDLKEMT 63   purple sea urchin
XP_019620474   25 WCVGDRCQAPCSyDGQYYTAVIRSVhtspaqstPRVTVKFCgfeSDENEEVPVaELRKLS 84   Belcher's lancelet
XP_013393764   17 WSKGELCKAPYSkDNKLYTAKVTSIkrn--grtTLACVHFIgydSVEDEDIPIsKLHKIP 74   Lingula anatina
XP_021357635   13 WSIGELCRAPYSkDTEYYVATIKKLkrk--qgnVIATVSFDgycSDETEDVDVnFLLKIA 70   Yesso scallop
XP_022089252    4 WQVGDKCMAPYSgDGLHYRACIKTLtkkl-qgrVMASVRFSgftEEEDEIVDVrHLKKRP 62   crown-of-thorns starfish
PVD22663       30 WSIGEHCRAEWSgNGKYYDGVIRKFrrle-agkVLALVKFLsydSDDSEEVDIqTLQKVK 88   Pomacea canaliculata
XP_007428270   13 WHVEDKCLAPFPeLGKLCDATIMSFetds-dgkCFAKVSFG---ENQEEKILTtKLSQIK 68   Burmese python

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