2FHD


Conserved Protein Domain Family
Tudor_SpCrb2-like_rpt1

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cd20395: Tudor_SpCrb2-like_rpt1 
first Tudor domain found in Schizosaccharomyces pombe Cut5-repeat binding protein 2 (Crb2) and similar proteins
Crb2, also called RAD9 protein homolog, or checkpoint mediator protein crb2, is a DNA repair protein essential for cell cycle arrest at the G1 and G2 stages following DNA damage by X-, and UV-irradiation, or inactivation of DNA ligase. Crb2 contains two Tudor domains. The model corresponds to the first one. The Tudor domain binds to proteins with dimethylated arginine or lysine residues, and may also bind methylated histone tails to facilitate protein-protein interactions.
Statistics
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PSSM-Id: 410466
Aligned: 9 rows
Threshold Bit Score: 67.3845
Created: 29-May-2019
Updated: 25-Oct-2021
Structure
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Program:
Drawing:
Aligned Rows:
 
putative
Conserved site includes 6 residues -Click on image for an interactive view with Cn3D
Feature 1:putative peptide binding site [polypeptide binding site]
Evidence:
  • Comment:based on the structures of other Tudor domain superfamily members with bound methylated/dimethylated peptides
  • Comment:In general, the Tudor domain binds to proteins with dimethylated arginine or lysine residues, and may also bind methylated histone tails to facilitate protein-protein interactions.

Sequence Alignment
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Format: Row Display: Color Bits: Type Selection:
Feature 1                #       # #                     # # #               
2FHD_A          9 KNRVLAFFKgy--psFYYPATLVApvhsavtsSIXYKVQFDDATXSTVNSn-QIKRFFL 64   fission yeast
OCF42091      919 PARVLALYSs-----YYYPARILGk------tGSKYSIQFDDGDTKSNVPthHMRQLIL 966  Kwoniella heveanensis CBS 569
KXT04929     1022 PERVFALFKgt--rqNYYPATYLGgs----adGMAYKIKFDDGTSTNVDTq-HVRRLEL 1073 Pseudocercospora eumusae
XP_023888845  595 PNRIFAFFKgkgtynNYYPATWLGla----anGYSFKVRFDDGTITSVQPd-QVCSLVL 648  Quercus suber
P87074        363 KNRVLAFFKgy--psFYYPATLVApvhsavtsSIMYKVQFDDATMSTVNSn-QIKRFFL 418  Schizosaccharomyces pombe 972h-
EKC97822      839 PLRVLALWTkt---rDYYIGTVTAr------nKTGYRVSFDDGLNRTVPVd-RMRLLDI 887  Trichosporon asahii var. asahii CB...
XP_007385574  709 PTRVVAKWDkd---gCYYSGTIVDrp-----sSGAWSVYFDDGSRASAIAtnDLRKCEF 759  Punctularia strigosozonata HHB-111...
CUA72195      754 GTRVLAWWSg----gNYFFGTIVShe-----gKSRYQIDFDDGSSSKVPLt-RIRRAAL 802  Rhizoctonia solani
KZS93056      573 GTRVFAFWKsd---gFYYSGTVTGpyh---ssSSKYSVLFDDSNSADVDIs-QLRQCIL 624  Sistotremastrum niveocremeum HHB9708

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