3MEU,3ME9,3MP6,3MP1,5C0M,3MEW,3MEA,3LX7


Conserved Protein Domain Family
Tudor_SGF29_rpt2
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cd20394: Tudor_SGF29_rpt2 
second Tudor domain found in SAGA-associated factor 29 (SGF29) and similar proteins
SGF29, also called coiled-coil domain-containing protein 101, or SAGA complex-associated factor 29, is a chromatin reader component of some histone acetyltransferase (HAT) SAGA-type complexes, like the TFTC-HAT, ATAC or STAGA complexes. It specifically recognizes and binds methylated 'Lys-4' of histone H3 (H3K4me), with a preference for trimethylated form (H3K4me3). SGF29 contains two Tudor domains. The model corresponds to the second one. The Tudor domain binds to proteins with dimethylated arginine or lysine residues, and may also bind methylated histone tails to facilitate protein-protein interactions.
Links
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Statistics
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PSSM-Id: 410465
Aligned: 56 rows
Threshold Bit Score: 62.6278
Created: 11-Dec-2018
Updated: 25-Oct-2021
Structure
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Program:
Drawing:
Aligned Rows:
Download Cn3D
 
peptide binding
Conserved site includes 7 residues -Click on image for an interactive view with Cn3D
Feature 1:peptide binding site [polypeptide binding site]
Evidence:
Download Cn3D for Viewing 3D StructureScroll to Sequence Alignment Display
Sequence Alignment
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Format: Row Display: Color Bits: Type Selection: 
Feature 1                  #  ##     # #                                   ##                    
3MEU_A       115 FQKEQLVLALYPQTT-----CFYRALIHAppqr-----------------pqdDYSVLFEDtsyadgYSPPLNVAqRYVV 172 human
Q1ZXN8       349 FSNNTKVLAMFPDTT-----AFYPAVVVNvqkvk---------------gkptFYHLHFEDdqe-ngETPNRRVNaQHVV 407 Dictyostelium d...
XP_002674681 303 FKKGDKVFAVFPDTT-----TFYPAIVDSvptk-----------------tskNYSLKFEDdee-dgKTPLRKVNfKYVM 359 Naegleria grube...
XP_004993299 192 FEVGDIVLAMYPQTT-----CFYKAVVNRpptq-----------------etpTYSLQFEDdnfgdgRIRYHEIAvKFVL 249 Salpingoeca ros...
XP_004365777 291 ISKGTHVMALYPQTT-----CFYPAVVFSppte-----------------trrDYLLNFSDdedvdgTTPEREVSvKFVL 348 Capsaspora owcz...
CEP00065     205 FQKDETVLAIFPQTT-----VFYPAVVVSgpkk-----------------nkgHYLLQFADd-----ETKQRKVPaHHVV 257 Plasmodiophora ...
OIR58462     253 FQPKRTVYALYPGTT-----AFYKGTVCEmptivgd----------eykrlkgRYSVLFDD------DTEKYSINpLYVL 311 Amphiamblys sp....
XP_001307758 209 YSNGTKVLALWPNDEddwtsLFYPAVVSAtpts-----------------kdpNYTLMFDG------SEVPMQVKqHFVV 265 Trichomonas vag...
XP_009493383 333 FPVGARVLGLYPDTT-----CFYAGTVVEppssrtkvtlsdvvpggdgvqsvpSYLIEYDHd-----DPPLKECAaRYVI 402 Fonticula alba
XP_001308374 217 YPTGSHVLALWPLDNdewtsAFYPATVVKvpsk-----------------tgsCYTLRFEGd----tDNDFKDVReNFVI 275 Trichomonas vag...

Feature 1          
3MEU_A       173 AC 174 human
Q1ZXN8       408 AL 409 Dictyostelium discoideum AX4
XP_002674681 360 SV 361 Naegleria gruberi strain NEG-M
XP_004993299 250 NF 251 Salpingoeca rosetta
XP_004365777 349 SA 350 Capsaspora owczarzaki ATCC 30864
CEP00065     258 PL 259 Plasmodiophora brassicae
OIR58462     312 GL 313 Amphiamblys sp. WSBS2006
XP_001307758 266 HA 267 Trichomonas vaginalis G3
XP_009493383 403 SL 404 Fonticula alba
XP_001308374 276 RD 277 Trichomonas vaginalis G3

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