3MEU,3MEW,3MET,5C0M,3MEA,3LX7,3ME9,3MP1,3MP6


Conserved Protein Domain Family
Tudor_SGF29_rpt1

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cd20393: Tudor_SGF29_rpt1 
first Tudor domain found in SAGA-associated factor 29 (SGF29) and similar proteins
SGF29, also called coiled-coil domain-containing protein 101, or SAGA complex-associated factor 29, is a chromatin reader component of some histone acetyltransferase (HAT) SAGA-type complexes, like the TFTC-HAT, ATAC or STAGA complexes. It specifically recognizes and binds methylated 'Lys-4' of histone H3 (H3K4me), with a preference for the trimethylated form (H3K4me3). SGF29 contains two Tudor domains. The model corresponds to the first one. The Tudor domain binds to proteins with dimethylated arginine or lysine residues, and may also bind methylated histone tails to facilitate protein-protein interactions.
Statistics
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PSSM-Id: 410464
Aligned: 87 rows
Threshold Bit Score: 48.4106
Created: 29-May-2019
Updated: 25-Oct-2021
Structure
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Program:
Drawing:
Aligned Rows:
 
peptide binding
Conserved site includes 4 residues -Click on image for an interactive view with Cn3D
Feature 1:peptide binding site [polypeptide binding site]
Evidence:

Sequence Alignment
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Format: Row Display: Color Bits: Type Selection:
Feature 1                                         # #                   # #                      
3MEU_A        41 YVARPGDKVAARVka-------------vDGDEQWILAEVVSYSHa--tNKYEVDDIDe----eGKERHTLSrRRVIPLP 101 human
Q4WSC1       337 GQLVIGAEVVFKHnkn-----------kqGVEGEGIQCIIKGISGdgpkKRYDVQDPEpnengeQGAVYKTTaASLIPIP 405 Aspergillus fum...
XP_003030748 174 LPLKPGRQVVYRLae------------ggTEDTSYILAIVVKLASkd-rTRYLVRDADpge-dgKFTEYRATlSNLIPLP 239 Schizophyllum c...
Q5K742       147 LPLQPGRKVAFKLpavkakgdgdtsvnggSSGDDWILATVKRCILqd-kMRYEVQDVD------DGNTYNTTlRSIIPLP 219 Cryptococcus ne...
XP_018226583 137 DILQVGSQVAFRQpk------------tkNSQGDWIQCIVTRVIGegskVKYEVQDPEpdenhhPGQIYKTVaSNLILIP 204 Pneumocystis ca...
GAO47424     138 AQITVGSQVAFKP----------------KGTSDWIQCNVIRLLGegskAKVDVQDPEpdd-nnTLHTFRTTvSSLIFVP 200 Saitoella compl...
TIB35714      22 IYLEPTHPVAFKLpkv-----------dhSIEDQWILAKIIQSINsd-iNQYKVQDVEpsedggPGQVWQTDlKSIIALP 89  Wallemia ichthy...
OSS51261     199 RRLSPNTEVLYRHnkq-----------raSNEGEGILCRVTSVIGdgkqRRYEIMDADpd--ltPNQPYRASvNHLVPIP 265 Epicoccum nigrum
KZW03334     160 PPLREGRMVGFRVpadt--------qnrdATEAEWILVSITKSAGn---GEYIVQDADae--ggVPVTYQATmRNLLLIP 226 Exidia glandulo...
XP_023921813 273 LVLRQGEMVFCRHdlknh------dvkkeVPDGEGILCQVTAVIGdgkqRRYEVQDVDpd--nePSKPQRASvSQLIQIP 344 Quercus suber
Feature 1           
3MEU_A       102 QWK 104 human
Q4WSC1       406 QVG 408 Aspergillus fumigatus
XP_003030748 240 DPA 242 Schizophyllum commune H4-8
Q5K742       220 DPD 222 Cryptococcus neoformans
XP_018226583 205 NSS 207 Pneumocystis carinii B80
GAO47424     201 PTS 203 Saitoella complicata NRRL Y-17804
TIB35714      90 VHS 92  Wallemia ichthyophaga
OSS51261     266 PPS 268 Epicoccum nigrum
KZW03334     227 DME 229 Exidia glandulosa HHB12029
XP_023921813 345 ESN 347 Quercus suber

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