2EQU,2LDM


Conserved Protein Domain Family
Tudor_PHF20-like

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cd20386: Tudor_PHF20-like 
Tudor domain found in PHD finger protein 20 (PHF20), PHF20-like protein 1 (PHF20L1), and similar proteins
PHF20, also called Glioma-expressed antigen 2, hepatocellular carcinoma-associated antigen 58, novel zinc finger protein, or transcription factor TZP (referring to Tudor and zinc finger domain containing protein), is a regulator of NF-kappaB activation by disrupting recruitment of PP2A to p65. It also functions as a transcription factor that binds to Akt and plays a role in Akt cell survival/growth signaling. Moreover, it transcriptionally regulates p53. The phosphorylation of PHF20 on Ser291 mediated by protein kinase B (PKB) is essential in tumorigenesis via the regulation of p53-mediated signaling. PHF20L1 is an active malignant brain tumor (MBT) domain-containing protein that binds to monomethylated lysine 142 on DNA (cytosine-5) Methyltransferase 1 (DNMT1) (DNMT1K142me1) and colocalizes at the perinucleolar space in a SET7-dependent manner. Both PHF20 and PHF20L1 contain an N-terminal malignant brain tumor (MBT) domain, a Tudor domain, a plant homeodomain (PHD) finger and putative DNA-binding domains AT hook and C2H2-type zinc finger. The Tudor domain binds to proteins with dimethylated arginine or lysine residues, and may also bind methylated histone tails to facilitate protein-protein interactions.
Statistics
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PSSM-Id: 410457
Aligned: 25 rows
Threshold Bit Score: 61.0686
Created: 12-Jul-2007
Updated: 25-Oct-2021
Structure
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Program:
Drawing:
Aligned Rows:
PubMed ReferencesClick to see Conserved Features Help

Sequence Alignment
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Format: Row Display: Color Bits: Type Selection:
2EQU_A         10 FKAGEEVLARWtDCRYYPAKIEAIn-kEGTFTVQFYDGVIRCLKRmHIKAM 59   human
FAA00196      958 FMKGETVLAKWvDCRLYFAKILQCf-aEDTYKIRYFDGHVKIVKEdFLRPY 1007 Ciona intestinalis
AAD38875      212 FEEGEDVLARWtDGNFYPATVVKVk-dTGSCVVMYFDGMKKLIRKnVMKKM 261  Molgula oculata
FAA00196     1093 YRAGEQVLCRWtDRKFYPATVIKQk-dLDHYLIKYFDNRKKVVKHnWLSPW 1142 Ciona intestinalis
XP_017464006   15 FQVDEEVLAKWtDSKFYPATIIEIq--NDFCKVLFEDGYQKKVKLsALKKI 63   snowberry fruit fly
OTF72582       27 FDLNEEILARWtDQQFYPARITTFyskGQYCQVLFYDGYRKKVKVsSLRKM 77   Euroglyphus maynei
EFX82597      108 FKVGEKVMAVWhNNKRYPAQITKVl-ePGNFEVIFYDGFSMQVKAkQMSRM 157  common water flea
XP_004348170  702 FSAHQRVMARWlDRKLYPATIRQVm-eGGSCDILFDDGFNKLASPsSMRHM 751  Capsaspora owczarzaki ATCC 30864
NP_731688     288 FELDEKCMARWsGPRKFPGTIRKLl-gNDTYEVLFDDGYVKNVRAvHMNKM 337  fruit fly
OWR46297      325 FVVGERCLARWrDNRRFIATILTDl-gNGNYEIMFDDGFKWKCTTsRMCKL 374  Danaus plexippus plexippus
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