4II1


Conserved Protein Domain Family
Tudor_ZGPAT
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cd20384: Tudor_ZGPAT 
Tudor domain found in zinc finger CCCH-type with G patch domain-containing protein (ZGPAT) and similar proteins
ZGPAT, also called ZIP, G patch domain-containing protein 6 (GPATC6), GPATCH6, zinc finger CCCH domain-containing protein 9 (ZC3HDC9), ZC3H9, or zinc finger and G patch domain-containing protein, is a transcription repressor that specifically binds the 5'-GGAG[GA]A[GA]A-3' consensus sequence. It represses transcription by recruiting the chromatin multiprotein complex NuRD to target promoters. It contains one Tudor domain. The Tudor domain binds to proteins with dimethylated arginine or lysine residues, and may also bind methylated histone tails to facilitate protein-protein interactions.
Links
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Statistics
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PSSM-Id: 410455
Aligned: 43 rows
Threshold Bit Score: 41.0563
Created: 30-Mar-2007
Updated: 25-Oct-2021
Structure
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Program:
Drawing:
Aligned Rows:
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putative
Conserved site includes 6 residues -Click on image for an interactive view with Cn3D
Feature 1:putative peptide binding site [polypeptide binding site]
Evidence:
  • Comment:based on the structures of other Tudor domain superfamily members with bound methylated/dimethylated peptides
  • Comment:In general, the Tudor domain binds to proteins with dimethylated arginine or lysine residues, and may also bind methylated histone tails to facilitate protein-protein interactions.
Download Cn3D for Viewing 3D StructureScroll to Sequence Alignment Display
Sequence Alignment
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Format: Row Display: Color Bits: Type Selection: 
Feature 1                       #    # #                       #   # #              
4II1_A        113 DLSSLqAGSACLAKHQd-GLWHAARITDVd--------NGYYTVKFdslLLREAVVEGd--GILPP 167  human
XP_019849943  202 DYSNIsVGTRCLVKQPd-ELWHEATVSFIe--------IDKVVVKFv-tQKQDAEVPLa--DVLPL 255  Amphimedon queenslandica
PNF16315       48 DFSAVrPGVRVLVKGDd-NLWHGAVVLTCs-------sKTKCEVKLe-sSGKAKEVDLh--WILPL 102  Cryptotermes secundus
ROT80515      208 DLSGLdSGSRVLVQHTd-DLWTNATVQDIle------dRSAFCVKLd-hSKAVAEVKPn--QIIPL 263  Pacific white shrimp
XP_002408356  210 SFSSMqLGSTCLIRNDsdGLWQLATVDSDqastlskssAGKIMVRLs-rSGKAISVAAe--DVLPL 272  black-legged tick
KRX84804      639 DFENLsVGSRCLVKCGseDLWKLASVTSIsl------eEGQIAARLa-nTGVVLAVNFe--HVFPL 695  Trichinella sp. T6
XP_026479378  200 DFSRIeNGDSVLVKQTn-QLWSKATVTDIe--------DNMLTVSSd--GKTHCIVNFe--DIIPI 252  cat flea
OQV13635      192 EFSSLtVGSRCLCVNDe-GIWEHGTVAGMsspsseadtTPEVTVRLa-gQTAVKTVKId--QIVPD 253  Hypsibius dujardini
CRL01656      171 NYSLLkKGCHALIKTEa-GLWKPGIIMECne------dSRTCRVKMqngGKVVENCSYs--DILPP 227  Clunio marinus
PDM70510     1583 DFESLaEGSPVLVSVD--PLWEVGRVTSKd--------GDQLAVKI---LRTGAEVSStiaAVLPI 1635 Pristionchus pacificus

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