4RG2,2IG0,1SSF,1XNI,5ZCJ,4CRI,3LGF,2G3R,4X34,5J26


Conserved Protein Domain Family
Tudor_53BP1

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cd20383: Tudor_53BP1 
Tudor domain found in tumor suppressor TP53-binding protein 1 (53BP1) and similar proteins
53BP1, also called p53-binding protein 1 (p53BP1), is a double-strand break (DSB) repair protein involved in response to DNA damage, telomere dynamics, and class-switch recombination (CSR) during antibody genesis. It plays a key role in the repair of DSBs in response to DNA damage by promoting non-homologous end joining (NHEJ)-mediated repair of DSBs and specifically counteracting the function of the homologous recombination (HR) repair protein BRCA1. It is recruited to DSB sites by recognizing and binding histone H2A monoubiquitinated at 'Lys-15' (H2AK15Ub) and histone H4 dimethylated at 'Lys-20' (H4K20me2), two histone marks that are present at DSB sites. 53BP1 contains one Tudor domain. The Tudor domain binds to proteins with dimethylated arginine or lysine residues, and may also bind methylated histone tails to facilitate protein-protein interactions.
Statistics
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PSSM-Id: 410454
Aligned: 32 rows
Threshold Bit Score: 58.8157
Created: 25-Jan-2019
Updated: 25-Oct-2021
Structure
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Program:
Drawing:
Aligned Rows:
 
peptide bindingligand binding
Conserved site includes 6 residues -Click on image for an interactive view with Cn3D
Feature 1:peptide binding site [polypeptide binding site]
Evidence:
  • Structure:4X34; Homo sapiens 53BP1 in complex with P53k381ack382me2, contacts at 4A
    View structure with Cn3D
  • Structure:2IG0; Homo sapiens 53BP1 in complex with dimethylated histone H4-k20 peptide, contacts at 4A
    View structure with Cn3D
  • Structure:4RG2; Homo sapiens 53BP1 binds competitive small molecule ligand UNC2170, contacts at 4A
    View structure with Cn3D

Sequence Alignment
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Format: Row Display: Color Bits: Type Selection:
Feature 1                 #       #                    # ###               
4RG2_A          6 VGLRVVAKWSs-NGYFYSGKITRDVg----aGKYKLLFDDGYECDVLgkDILLCDPI 57   human
4X34_A          4 VGLRVVAKWSs-NGYFYSGKITRDVg----aGKYKLLFDDGYECDVLgkDILLCDPI 55   human
RDD46298     1241 IGNRVFARWSlsDSHYYPGRVVRGDrs---nSRYTIAFDDGTKSTISskHIVVKENL 1294 Trichoplax sp. H2
XP_013402074 1302 TGTNVLARWK--DGFFYPGVFISVEk----nGKYLVYFDDEDQRQVKaaDLIVNPEL 1352 Lingula anatina
OWF47938     1409 VGARVLARWK--DGFYYPGSIAQILk-----SKYQVRFDDGDVRFVKvsDLLLIERL 1458 Yesso scallop
PIK55952       13 LGSQVAAPWQ--DGIFYPGIVKSVTsrpmgdTLYTVEFDDKYIKNFTdrQIMIGNCF 67   Japanese sea cucumber
RMX38506     1418 PGTRVLAKWL--DGYFYPGIITAKQyk---nGRYSVTFDDGDKRRIPreNLIIKDLL 1469 Pocillopora damicornis
XP_011660955 1609 PGVRVFTRWM--DGFYYPGTIKKEEk----nNRLKIAFDDGDMRSVNskDVIIKDWL 1659 purple sea urchin
ELU05990      554 EGTNVFAMWK--NKSFYPGKIKSNLt----rDRYTVQYEDGAVKQVKaaDLIICNLL 604  Capitella teleta
XP_004993812 1533 AGTRVFAQWPh-DPFYYPGSVQRVFk-----KGFRVDFDDDSHMTVK--RIVVGFEF 1581 Salpingoeca rosetta

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