2DIG,2L8D


Conserved Protein Domain Family
Tudor_LBR

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cd20381: Tudor_LBR 
Tudor domain found in Lamin-B receptor (LBR) and similar proteins
LBR, also called integral nuclear envelope inner membrane (INM) protein or LMN2R, is a nuclear envelope protein that anchors the lamina and the heterochromatin to the inner nuclear membrane, in cellular senescence induced by excess thymidine. It is also important for cholesterol biosynthesis. LBR can interact with chromodomain proteins and DNA. It contains one Tudor domain. The Tudor domain binds to proteins with dimethylated arginine or lysine residues, and may also bind methylated histone tails to facilitate protein-protein interactions.
Statistics
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PSSM-Id: 410452
Aligned: 17 rows
Threshold Bit Score: 71.5667
Created: 30-Mar-2007
Updated: 25-Oct-2021
Structure
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Program:
Drawing:
Aligned Rows:
 
putative
Conserved site includes 6 residues -Click on image for an interactive view with Cn3D
Feature 1:putative peptide binding site [polypeptide binding site]
Evidence:
  • Comment:based on the structures of other Tudor domain superfamily members with bound methylated/dimethylated peptides
  • Comment:In general, the Tudor domain binds to proteins with dimethylated arginine or lysine residues, and may also bind methylated histone tails to facilitate protein-protein interactions.

Sequence Alignment
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Format: Row Display: Color Bits: Type Selection:
Feature 1                   #     # #                 # # #             
2DIG_A        12 KFADGEVVRGRWPGSs-LYYEVEILSHDstsQLYTVKYKDGTELELKe--NDIKS 63  human
CAB44317       9 KYEIGETVMGRWPGSs-LYYEVQVVGFNsksQEYKVLYKDGTDLDLKe--GDIKR 60  African clawed frog
PIK61428      13 GFNVGEQVRAKWPGSr-LWYKATILEELs--DGFKVKFEDGTEDELDf--NDVAI 62  Japanese sea cucumber
ALS04042      43 TYKEGEAVMARWPGSr-LYYNAQVVSAIsatGEYEVEFENGITFTLTp--KDVYK 94  Paracalanus parvus
XP_013404620   9 SHDVGDEVYAKWPGSn-LWFRAKVLNNKd--GRYTVRYMEGTEETISq--KHISA 58  Lingula anatina
XP_019647863   4 RHDAGQTVMAKWPGSh-LWFHAKVLKTLd-gDRYMVRFEEGTEEEVDa--HHVLS 54  Belcher's lancelet
XP_018010670   5 KFNIGERVRAKWPGSg-LYFEGEIEDFNd--IEYLVKFDDEDESKLAvkyRDVAA 56  Hyalella azteca
XP_012553926   5 KHKDGDIVYAKWPGSd-LYYKASVENFNpisNQYRVKFLTEKEGDVDenvFDIPS 58  Hydra vulgaris
KZS15956       7 YYQNGESVFGLWPGSggLYFKGVVVNRDpvtGFYDVKFEEGTTYTLHg--KHVKA 59  Daphnia magna
XP_020915331   5 EIKVGEKVYARWPGSv-KYYEAIVDEVLx--DEFVVSFIEGSLTATLd-eRHVYR 55  Exaiptasia pallida

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