Conserved Protein Domain Family
Tudor_TDRD13-like

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cd20380: Tudor_TDRD13-like 
Tudor domain found in Tudor domain-containing protein 13 (TDRD13) and similar proteins
The TDRD13 family includes TDRD13 and OTU domain-containing protein 4 (OTUD4). TDRD13, also called asparagine-linked glycosylation 13 (ALG13), glycosyltransferase 28 domain-containing protein 1 (GLT28D1), or UDP-N-acetylglucosamine transferase subunit ALG13, is a putative bifunctional UDP-N-acetylglucosamine transferase and deubiquitinase (EC 2.4.1.141/EC 3.4.19.12). It is a potential member of the Alg7p/Alg13p/Alg14p complex catalyzing the first two initial reactions in the N-glycosylation process. OTUD4, also called HIV-1-induced protein HIN-1, is a phospho-activated K63 deubiquitinase that hydrolyzes the isopeptide bond between the ubiquitin C-terminus and the lysine epsilon-amino group of the target protein. It may negatively regulate inflammatory and pathogen recognition signaling in innate immune response. Members of this family contain one Tudor domain. The Tudor domain binds to proteins with dimethylated arginine or lysine residues, and may also bind methylated histone tails to facilitate protein-protein interactions.
Statistics
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PSSM-Id: 410451
Aligned: 28 rows
Threshold Bit Score: 57.9767
Created: 11-Dec-2006
Updated: 25-Oct-2021
Structure
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Aligned Rows:
 
putative
Feature 1:putative peptide binding site [polypeptide binding site]
Evidence:
  • Comment:based on the structures of other Tudor domain superfamily members with bound methylated/dimethylated peptides
  • Comment:In general, the Tudor domain binds to proteins with dimethylated arginine or lysine residues, and may also bind methylated histone tails to facilitate protein-protein interactions.

Sequence Alignment
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Format: Row Display: Color Bits: Type Selection:
Feature 1                    #                   # #                   #  # #            
Q9NP73        492 QYYLGDKCQVCLes---------------egRYYNAHIQEVg--nENNSVTVFIeeLAEKHVVplaNLKPV 545  human
XP_022240718  193 DLAPGVKCVVNLde----------------dQNYAGHIQEMs--pDQGPVTVFIekLGEKRVVpyeNLQPL 245  Atlantic horseshoe crab
EFX89797      272 ILQIGSKCMVTIndn--------------pnHQYPAYIQDMq--pDKGPVTVFVevLGEMCTVpydNIEPI 326  common water flea
XP_026822960  259 EFKEGSKCMVSIg-----------------tQGYHCYIQRIh--gKNEPVEVYVkdLAQKMYVeydQLKLI 310  corn leaf aphid
QAB02869      270 ELKVGAKCLVTLnp----------------eTVYVAHIQKMs--eDHGPVTIFVeaLGQMLSVpyeKLSLL 322  Bemisia tabaci
XP_011871005  267 ELQVGGKCLIQIsindleqcd-rnnnknqgpLWLHGYIQEMn--tEKEPVLVFIkdLGEKKFVpydALKPL 334  Vollenhovia emeryi
RZB39464      256 NLILGTKCLLNRn-----------------dRTFECYIQEIi--kNKNKCVVYVtkLAEKLTVnytDLSPE 307  Asbolus verrucosus
KFM60787      217 KLEPGVKCKVYIn-----------------kEIYIGHVQDIl--sDTEDVSVYIeeLCKRCVVs-sNVIEI 267  Stegodyphus mimosarum
XP_019773803  253 KLTIGTKCVLNDek---------------tgKPMECYIQKLd--kEEDKCMVYItkLAELKWVcylDLAPE 306  mountain pine beetle
XP_008484514  289 EQKRGSRCGLEIwsnsrlvrgvscivrfpngEGATCHIQDVdpvsKEYKVYVVKekQGRMITVpmeWLEPL 359  Asian citrus psyllid

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