Conserved Protein Domain Family
FXYD12

?
cd20330: FXYD12 
FXYD domain-containing ion transport regulator 12
The FXYD domain-containing ion transport regulator 12 (FXYD12) mRNA is mainly distributed in kidneys and intestines of fish. In co-immunoprecipitation experiments, FXYD12 was shown to associate with the Na(+)/(K+)-ATPase (NKA) alpha-subunit in the intestines of two closely related medakas, Oryzias dancena and O. latipes. These results suggests that FXYD12 may play a role in modulating NKA activity in the intestines following salinity changes in the maintenance of internal homeostasis.
Statistics
?
PSSM-Id: 410565
Aligned: 20 rows
Threshold Bit Score: 68.4675
Created: 8-Apr-2019
Updated: 17-Oct-2022
Structure
?
Aligned Rows:
 
putative trimer
Feature 1:putative trimer interface [polypeptide binding site]
Evidence:
  • Comment:based on structures of the Na+/K+ ATPase heterotrimer, composed of alpha, beta, and gamma (FXYD2 or phospholemman-like protein) subunits

Sequence Alignment
?
Format: Row Display: Color Bits: Type Selection:
Feature 1               # # #  ##  ## ##  #  ### ## #                 
NP_001117202   8 EYDPDAEFVYDYQTLRIGGLTFVAVIMILSVLLLASNKIRQCGKPRVSVLISD 60  Atlantic salmon
XP_026221139  44 ETDYDADFVYDYYTLRVGGLAFAGVIVFLSIILLAGNKIRNCGKSKPRHVEEE 96  climbing perch
XP_006795588  49 DVDLDADFVYDYEKLRLGGLIFAGVIVFLSIILLAGNKIRNCGKSKPRRSDEE 101 Neolamprologus brichardi
XP_019129800  54 NVDLDADFVYDYHTLRVGGLVFAGVIVFLSIILLAGNKLANCGKTPKPRAAEE 106 large yellow croaker
AWO98995       8 DIDPDADFVYDYYTLRVGGLVFAGVIVFLSIILLAGNKIANCGKSKPKHVEED 60  turbot
XP_018949345  26 TVDPDADFFYDYENLRIGGLIFAGVIVILSVLLLTGNRIKRCGKRKAKNVDEE 78  common carp
RXN22733     548 TLNPDADFVYDYENLRIGGLIFAGVIVVLSVFLLAGNSIKRCGKRKVSTLNLL 600 rohu
XP_016355894  22 QLDPDADFYYDYETLRIGGLVFAGVIVVLSVLLLTGNRIRRCGKPKKPLLSKK 74  Sinocyclocheilus anshuiensis
TRY86687      52 SVDPDADFFYDYESLRIGGLVFAGVIVVLSVLLLTGNRIRRCGKGKGKHGGDT 104 Danionella translucida
XP_031429818  20 EYEPDPEFVYDYHTLRIAGLTFAGVVTLFSVLMLTCNKIRRCGKPKPKPVEED 72  Atlantic herring

| Disclaimer | Privacy statement | Accessibility |
NCBI Home NCBI Search NCBI SiteMap