LYR (leucine-tyrosine-arginine) motif found in mitochondrial elongation factor 1 microprotein (MIEF1-MP) and similar proteins
MIEF1-MP, also called alternative mitochondrial elongation factor 1 (MIEF1) protein (AltMIEF1), or MIEF1 upstream open reading frame protein, is involved in the regulation of mitochondrial fission mediated by dynamin-1-like protein (DNM1L). It positively regulates mitochondrial translation. MIEF1-MP belongs to the Complex1_LYR-like superfamily that consists of proteins of diverse functions that are exclusively found in eukaryotes and contain the conserved tripeptide 'LYR' close to the N-terminus.
Structure:5OOL; Homo sapiens MIEF1-MP interacts with MALSU1 and NDUFAB1 within a native assembly intermediate of the human mitochondrial ribosome, contacts at 4A.
Jiyao W et al.(2023). "The conserved domain database in 2023.",