5XTB,5USR,5OOL,5XTC


Conserved Protein Domain Family
Complex1_LYR_SF

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cd20251: Complex1_LYR_SF 
LYR (leucine-tyrosine-arginine) motif found in Complex1_LYR-like superfamily
The Complex1_LYR-like superfamily consists of proteins of diverse functions that are exclusively found in eukaryotes and contain the conserved tripeptide 'LYR' close to the N-terminus. The human genome has at least ten LYR proteins that were predominantly identified as mitochondrial proteins. Some family members were also found in the cytosol or nucleus. LYR motif-containing protein 4 (LYRM4) represents the only LYR protein that is directly involved in the first steps of Fe-S cluster generation. Other LYR proteins have been identified as accessory subunits or assembly factors of mitochondrial OXPHOS (oxidative phosphorylation) complexes I, II, III and V, and they play specific roles in acetate metabolism.
Statistics
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PSSM-Id: 380755
Aligned: 53 rows
Threshold Bit Score: 37.1394
Created: 26-Jul-2016
Updated: 2-Oct-2020
Structure
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Program:
Drawing:
Aligned Rows:
 
LYR motif
Conserved site includes 3 residues -Click on image for an interactive view with Cn3D
Feature 1:LYR motif
Evidence:
  • Comment:members of this family contain the conserved tripeptide 'LYR' close to the N-terminus

Sequence Alignment
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Format: Row Display: Color Bits: Type Selection:
Feature 1           ###                                                         
5XTB_E        17 VRELYRAWYREvpntvhqfqlDITVKMGRDKVREMFMKNahv--tdPRVVDLLVIKGKIELEE 77  human
5USR_B         9 VLALYRAMLREskr----fsaYNYRTYAVRRIRDAFRENknv--kdPVEIQTLVNKAKRDLGV 65  Homo sapiens
A8MSI8        13 PLQLYRYLLRCcqq----lptKGIQQHYKHAVRQSFRVHsde--dnPERIQQIIKRAIEDADW 69  human
Q5U5X0         7 VLQLFKTLHRTrqqv--fkndARALEAARIKINEEFKNNkse--tsSKKIEELMKIGSDVELL 65  human
A6NFY7        11 VLSLYRDLLRA----------GRGKPGAEARVRAEFRQHaglprsdVLRIEYLYRRGRRQLQL 63  human
Q4WQA0         8 GLALYRALLRQcsrl---pgaVPELQTSKLLIQQKFRKYknl--qsPSQTANALKAGYEALDL 65  Aspergillus fumigatus
XP_004336690   7 ALKVYRDLLRTqhtv--fsgdALAQERARSLIRQEFEAHrgv--qdAKEIDDLIARGNDTIAY 65  Acanthamoeba castellanii str. Neff
Q54SL9        15 ILKLFRNILRErlg----fptENRREYILIKTRQEFRKAkne--tdPKKLRGLTIIGNTQLDT 71  Dictyostelium discoideum AX4
XP_001697032   8 VLSLFRSFLREarl----mptEVRANHIRRKVRSELEAHrhe--adPERLAFLVGLAELQLEN 64  Chlamydomonas reinhardtii
OQR92994       6 AISFYRSIYRAagl----lpsKDRTQFVRRRLRSEYEKYlhe--tnPERISFLLQVADTQLDT 62  Achlya hypogyna

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