5T1J


Conserved Protein Domain Family
T-box_TBX21

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cd20203: T-box_TBX21 
Click on image for an interactive view with Cn3D
DNA-binding domain of T-box transcription factor 21 and related T-box proteins
TBX21 (also known as T-cell-specific T-box transcription factor T-bet or transcription factor TBLYM) is a lineage-defining transcription factor which directs T helper type 1 (Th1) cell differentiation. It initiates Th1 lineage development from naive T helper precursor cells both by initiating the Th1 genetic programs and by inhibiting the opposing Th2 and Th17 lineage-commitment programs. This subfamily belongs to the T-box family of transcription factors which play a multitude of diverse functions throughout development. The founding member of the T-box family is Brachyury (also known as TBXT, or T). T-box family members share a conserved DNA-binding domain (T-box) which binds DNA in a sequence-specific manner. Common features shared by T-box family members are DNA-binding and transcriptional regulatory activity, a role in development, and conserved expression patterns.
Statistics
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PSSM-Id: 410329
Aligned: 6 rows
Threshold Bit Score: 390.858
Created: 8-Mar-2019
Updated: 25-Oct-2021
Structure
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Program:
Drawing:
Aligned Rows:
 
DNA bindinghomodimer
Conserved site includes 17 residues -Click on image for an interactive view with Cn3D
Feature 1:DNA binding site [nucleic acid binding site]
Evidence:
  • Comment: TBX5 T-box monomers dimerize upon DNA binding, forming tight dimers
  • Structure:5T1J; Mus musculus TBX21 monomer binds DNA, contacts at 4A.

Sequence Alignment
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Format: Row Display: Color Bits: Type Selection:
Feature 1                                    ##                                # #               
5T1J_A        13 KLRVALSNHLLWSKFNQHQTEMIITKQGRRMFPFLSFTVAGLEPTSHYRMFVDVVLVDQHHWRYQSGKWVQCGKAEGsMP 92  house mouse
KYO44312     166 KVQVVLNNYPLWAKFHKHQTEMIITKQGRRMFPFLSFNLTGLDPVAHYNVCVDIVLVDQHHWRYQGGKWVQCGKAEGnMP 245 American alligator
NP_001164070 150 KTQVLLNNYPLWAKFHKYQTEMIITKQGRRMFPFLSFNITSLDPSAHYNIYVDVVLADQHHWRYQGGKWVQCGKAEGnMP 229 zebrafish
XP_005990126 142 KIQVLLNNYALWAKFHKHQTEMIITKQGRRMFPFLSFNITGLDPTAHYEVYVDIVLADQHHWRYQGGKWVQCGKAEGnMP 221 coelacanth
Q9UL17       136 KLRVALNNHLLWSKFNQHQTEMIITKQGRRMFPFLSFTVAGLEPTSHYRMFVDVVLVDQHHWRYQSGKWVQCGKAEGsMP 215 human
XP_018421097 137 KKQVTLANHHLWSKFHKHHTEMIITKQGRRMFPFLSYRLLGLDPLAQYTLHVEVALADQNHWRFQGGKWIQCGKAEGnMP 216 Nanorana parkeri
Feature 1                                   #  #               ##                                
5T1J_A        93 GNRLYVHPDSPNTGAHWMRQEVSFGKLKLTNNKGAsNNVTQMIVLQSLHKYQPRLHIVEVNDGEpeaacsasnTHVFTFQ 172 house mouse
KYO44312     246 GNRLYVHPDSPNTGAHWMRQEVSFGKLKLTNNKGAsNNVTQMIVLQSLHKYQPRLHVTEVKDGEgdesypsarTQTFTFP 325 American alligator
NP_001164070 230 GNRMYMHPDSPNTGTHWMRQEVSFGKLKLTNNKGSsNNVAQMIVLQSLHKYQPRLHIVEVKEDGtedpfltskTQTFVFP 309 zebrafish
XP_005990126 222 GNMMYTHPDSPNTGAHWMRQEVSFGKLKLTNNKGAcNNTSQMIVLQSLHKYQPRLHIIETKEEDtdetyssskSQTFTFL 301 coelacanth
Q9UL17       216 GNRLYVHPDSPNTGAHWMRQEVSFGKLKLTNNKGAsNNVTQMIVLQSLHKYQPRLHIVEVNDGEpeaacnasnTHIFTFQ 295 human
XP_018421097 217 GNRIYQHPDSPNTGAHWMRQEVVFSKLKLTNNKGAsSNTTQMVVLQSLHKYQPCLHVRRVTESGvve----thSHTFTFP 292 Nanorana parkeri
Feature 1               # #     #  #   ###  ##  
5T1J_A       173 ETQFIAVTAYQNAEITQLKIDNNPFAKGFRE 203 house mouse
KYO44312     326 ETQFIAVTAYQNADITQLKIDHNPFAKGFRD 356 American alligator
NP_001164070 310 ETQFIAVTAYQNADITQLKIDHNPFAKGFRD 340 zebrafish
XP_005990126 302 ETQFVAVTAYQNADITQLKIDHNPFAKGFRD 332 coelacanth
Q9UL17       296 ETQFIAVTAYQNAEITQLKIDNNPFAKGFRE 326 human
XP_018421097 293 ETQFIAVTAYQNAEITQLKIDHNPFAKGFRD 323 Nanorana parkeri

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