3PFS


Conserved Protein Domain Family
PWWP_BRPF3
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cd20158: PWWP_BRPF3 
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PWWP domain found in bromodomain and PHD finger-containing protein 3 (BRPF3)
BRPF3 is a homolog of BRPF1 and BRPF2. It is a scaffold protein that forms a novel monocytic leukemic zinc finger protein (MOZ)/MOZ-related factor (MORF) H3 histone acetyltransferase (HAT) complex with other regulatory subunits. BRPF3 contains a plant homeodomain (PHD) finger followed by a non-canonical extended PHD (ePHD) finger, C2HC5HC2H, a bromodomain, and a proline-tryptophan-tryptophan-proline (PWWP) domain. The PHD finger binds to lysine 4 of histone H3 (K4H3), the bromodomain interacts with acetylated lysines on N-terminal tails of histones and other proteins, and the PWWP domain shows histone-binding and chromatin association properties.
Links
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Statistics
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PSSM-Id: 438986
Aligned: 7 rows
Threshold Bit Score: 253.709
Created: 9-Jan-2019
Updated: 17-Oct-2022
Structure
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Program:
Drawing:
Aligned Rows:
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Conserved site includes 13 residues -Click on image for an interactive view with Cn3D
Feature 1:putative methyl-histone binding site [polypeptide binding site]
Evidence:
  • Comment:based on the structure of human BRPF1 bound to H3K36me3 peptide in an aromatic cage
  • Comment:the aromatic residues form the three-walled methyl-lysine cage that directly participate in histone methylated lysine binding and recognition.
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Sequence Alignment
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Format: Row Display: Color Bits: Type Selection: 
Feature 1                      #  #                   ###                         ## # #####      
3PFS_A         37 LEPLELVWAKCrGYPSYPALIIDPKMPREgllHNGVPIPVPPLDVLKLGEQKqae-ageKLFLVLFFDNKRTWQWLPRdK 115  human
XP_014343588 1052 LEPLELVWAKCrGYPSYPALIIDANMPREgllHNGVPIPVPPLDVLKLGEQKqve-ageKLFLVLFFDNKRTWQWLPRdK 1130 coelacanth
Q9ULD4       1074 LEPLELVWAKCrGYPSYPALIIDPKMPREgllHNGVPIPVPPLDVLKLGEQKqae-ageKLFLVLFFDNKRTWQWLPRdK 1152 human
EMP32317     1041 LEPLELVWAKCrGYPSYPALIIDPKMPREgllHNGVPIPVPPLDVLKLGEQKqte-ageKLFLVLFFDNKRTWQWLPRdK 1119 Green sea turtle
NP_001128279  851 LQPLQLVWAKCrGYPSYPALIIDPKMPREgllHNGVPIPVPPLEVLNLGEQRhieaegqQLFLVLFFDNKRTWQWLPSdK 930  tropical claw...
KTG05667        7 PDLTGLVWAKSrGYPSYPALIIDPDMPQEgllHNGVPIPVPPLDVLHLGEQRqee-ageKLFLVLFFDNKRTWQWLSRdK 85   common carp
XP_007892454 1054 LEPLELVWAKCrGYPSYPALIIDPHMPRDglyHNGVPIPVPPMDVIKLGEQMqae-ageKLYLVLFFDNKRTWQWLPRtK 1132 elephant shark

Feature 1                                                
3PFS_A        116 VLPLGVeDTVDKLKMLEGRktsIRKSVQVAYDRAMIHLS 154  human
XP_014343588 1131 VLPLGAdDTVDKLKMMEGRktsIRKSVQVAYDRAMIHMS 1169 coelacanth
Q9ULD4       1153 VLPLGVeDTVDKLKMLEGRktsIRKSVQVAYDRAMIHLS 1191 human
EMP32317     1120 VLPLGVdDTVDKLKMMEGRktsIRKSVQVAYDRAMIHMS 1158 Green sea turtle
NP_001128279  931 VIPLGAdDTLDKLKMLEGRkasIRKSVQVAYDRAMNHRS 969  tropical clawed frog
KTG05667       86 VIPLGVdDTADKLRMMEGKktsIRKSVQVAYDRAMIHLS 124  common carp
XP_007892454 1133 LLPLGIdDTVDKLKMMEGRkssIRKSVQIAYDRAMIHLS 1171 elephant shark

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