4Z02,3LYI


Conserved Protein Domain Family
PWWP_BRPF2
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cd20157: PWWP_BRPF2 
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PWWP domain found in bromodomain and PHD finger-containing protein 2 (BRPF2)
BRPF2, also called bromodomain-containing protein 1 (BRD1), or BR140-likeprotein, is encoded by BRL (BR140 Like gene). It is responsible for the bulk of the acetylation of H3K14 and forms a novel monocytic leukemic zinc-finger protein (MOZ)/MOZ-related factor (MORF) H3 histone acetyltransferase (HAT) complex with HBO1 and ING4. The complex is required for full transcriptional activation of the erythroid-specific regulator genes essential for terminal differentiation and survival of erythroblasts in fetal liver. BRPF2 shows widespread expression and localizes to the nucleus within spermatocytes. It contains a cysteine rich region harboring a plant homeodomain (PHD) finger followed by a non-canonical extended PHD (ePHD) finger, C2HC5HC2H, a bromodomain, and a proline-tryptophan-tryptophan-proline (PWWP) domain. The PHD finger binds to lysine 4 of histone H3 (K4H3), the bromodomain interacts with acetylated lysines on N-terminal tails of histones and other proteins, and the PWWP domain shows histone-binding and chromatin association properties.
Links
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Statistics
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PSSM-Id: 438985
Aligned: 8 rows
Threshold Bit Score: 252.55
Created: 9-Jan-2019
Updated: 17-Oct-2022
Structure
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Program:
Drawing:
Aligned Rows:
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Conserved site includes 13 residues -Click on image for an interactive view with Cn3D
Feature 1:putative methyl-histone binding site [polypeptide binding site]
Evidence:
  • Comment:based on the structure of human BRPF1 bound to H3K36me3 peptide in an aromatic cage
  • Structure:4Z02; Homo sapiens BRPF2 in complex with isoquinoline-3-carboxylic acid in the methyl-histone binding site, contacts at 4A
  • Comment:the aromatic residues form the three-walled methyl-lysine cage that directly participate in histone methylated lysine binding and recognition.
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Sequence Alignment
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Format: Row Display: Color Bits: Type Selection: 
Feature 1                      #  #                   ###                        ## # #####       
4Z02_A          3 LEPLKVVWAKCSGYPSYPALIIDPKMPRVpGHHNGVTIPAPPLDVLKIGEHMQTKSdEKLFLVLFFDNKRSWQWLPKSKM 82   human
3LYI_A          4 LEPLKVVWAKCSGYPSYPALIIDPKMPRVpGHHNGVTIPAPPLDVLKIGEHMQTKSdEKLFLVLFFDNKRSWQWLPKSKM 83   human
O95696        927 LEPLKVVWAKCSGYPSYPALIIDPKMPRVpGHHNGVTIPAPPLDVLKIGEHMQTKSdEKLFLVLFFDNKRSWQWLPKSKM 1006 human
NP_001085846  924 LEPLKVVWAKCSGYPSYPALIIDPKMPRVgCHHNGVAIPVPPMDVLKTGDQMQTRAeEKLFLVLFFDNKRSWQWLPKSKM 1003 African clawe...
NP_001186411  927 LEPLKVVWAKCSGYPSYPALIIDPKMPRVaGHHNGVTIPVPPLDVLKIGEQMQTKSdEKLFLVLFFDNKRSWQWLPKSKM 1006 chicken
XP_007889173 1056 MEPLKLIWAKCSGYPSYPALVIDPKVSRNgCRHNGVLIPTPPQDVLKIGESMQRKSvEKLFLVLFFDNKRSWQWLPKSKV 1135 elephant shark
XP_009298729 1010 LEPLKVVWAKCSGYPSYPALIIDPQMPRVgCQHNGVSIPMPPLNVLQIGEQMQYKSeEKLYLVLFFDNKRTWQWLHKSKM 1089 zebrafish
XP_014350871 1012 LEPLKLVWAKCSGYPSYPALIIDPKMPRVgCNHNGVIIPVPPMEVLKIGEQMQTKSgEKLFLVLFFDNKRSWQWLPKSKM 1091 coelacanth

Feature 1                                                 
4Z02_A         83 VPLGIDETIDKLKMMEGRNSSIRKAVRIAFDRAMNHLSRV 122  human
3LYI_A         84 VPLGIDETIDKLKMMEGRNSSIRKAVRIAFDRAMNHLSRV 123  human
O95696       1007 VPLGIDETIDKLKMMEGRNSSIRKAVRIAFDRAMNHLSRV 1046 human
NP_001085846 1004 VPLGVDETIDKLKMMEGRNSSIRKAVRVAYDRALNHLNRV 1043 African clawed frog
NP_001186411 1007 VPLGIDETIDKLKMMEGRNSSIRKAVRIAFDRAMNHLSRV 1046 chicken
XP_007889173 1136 VPLGIDETIDKIKMMEGRTSSIRKSVRIAFDRAMLHQCRV 1175 elephant shark
XP_009298729 1090 VPLGVDKTIDKIKMMEGRTSAIRKAVRTAFNRAMNHLNHV 1129 zebrafish
XP_014350871 1092 IPLGVDETIDKLKMMEGRNSSIRKAVRVAFDRAMNHLSRV 1131 coelacanth

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